2021
DOI: 10.1016/j.pscychresns.2021.111367
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Extending the “resting state hypothesis of depression” – dynamics and topography of abnormal rest-task modulation

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Cited by 11 publications
(4 citation statements)
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“…Another complementary perspective of the findings, which show the correlation between 5-HT 2a and 5-HT 1a serotonergic receptors and regions with difference in the intervention between the groups, is that of the overactivation of DMN in depression both in terms of its connectivity profile and temporal characterization. 22-24 , 63 It has been shown that serotonergic raphe nuclei have direct anatomical projections to the regions of DMN and 5HT 2 receptors expressed in DMN regions, 64 and it is thus possible that the psychedelic action enables modulation of the DMN via serotonergic pathways in responders but not non-responders.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Another complementary perspective of the findings, which show the correlation between 5-HT 2a and 5-HT 1a serotonergic receptors and regions with difference in the intervention between the groups, is that of the overactivation of DMN in depression both in terms of its connectivity profile and temporal characterization. 22-24 , 63 It has been shown that serotonergic raphe nuclei have direct anatomical projections to the regions of DMN and 5HT 2 receptors expressed in DMN regions, 64 and it is thus possible that the psychedelic action enables modulation of the DMN via serotonergic pathways in responders but not non-responders.…”
Section: Discussionmentioning
confidence: 99%
“…Such behaviour has been linked to the abnormal spatio-temporal organization of resting state activity. 22 Converging findings have found the overactivation of default mode network (DMN) and hypoconnectivity in the control executive network in MDD. 23-25 This is consistent with the triple-network model whereby depressive states promote the inward and self-referential experience at the expense of the interactions and attention towards the external environment.…”
Section: Introductionmentioning
confidence: 99%
“…According to the resting-state hypothesis of depression proposed by Northoff et al 34 and expanded by Gupta et al, 35 the abnormality in the resting-state brain activity is the core feature of MDD and one of the most consistent findings among the variety of different and in part contradictory findings in MDD. In this study, DMN, AN, VN, SMN, and cerebellar networks contributed the most to distinguishing RD and NRD.…”
Section: Discussionmentioning
confidence: 99%
“…These changes in spontaneous brain activity occur synchronously in certain brain regions and can fluctuate across networks dynamically. The fluctuations among these functional intrinsic connectivity networks can be associated with certain mental states and physiological states (Chen et al, 2020 ) during rest or they can influence mental processing, cognitive performance or brain activity during task-related activity following the resting state in healthy or vulnerbale individuals (e.g., Northoff et al, 2010 ; Gupta et al, 2021 ; Wolff et al, 2022 ). Several resting state brain networks have been identified that might be hierachically organized and whose intrinsic activity is distinct from or partially overlapping with task-related or task-positive brain networks that change activity when processing or performing a certain task (for an overview e.g., Seitzman et al, 2019 ).…”
Section: Summary Of the Research Contributions Of The Research Topicmentioning
confidence: 99%