BackgroundThis study presents the development of a backpropagation neural network‐based respiratory motion modelling method (BP‐RMM) for precisely tracking arbitrary points within lung tissue throughout free respiration, encompassing deep inspiration and expiration phases.MethodsInternal and external respiratory data from four‐dimensional computed tomography (4DCT) are processed using various artificial intelligence algorithms. Data augmentation through polynomial interpolation is employed to enhance dataset robustness. A BP neural network is then constructed to comprehensively track lung tissue movement.ResultsThe BP‐RMM demonstrates promising accuracy. In cases from the public 4DCT dataset, the average target registration error (TRE) between authentic deep respiration phases and those forecasted by BP‐RMM for 75 marked points is 1.819 mm. Notably, TRE for normal respiration phases is significantly lower, with a minimum error of 0.511 mm.ConclusionsThe proposed method is validated for its high accuracy and robustness, establishing it as a promising tool for surgical navigation within the lung.