2001
DOI: 10.1126/science.1057991
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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Abstract: The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans , insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaire… Show more

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Cited by 1,342 publications
(1,094 citation statements)
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References 23 publications
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“…As aging is the major risk factor for multiple pathologies, including cardiovascular diseases, neurodegenerative disorders and cancer (Niccoli & Partridge, 2012), finding interventions that can increase health during aging is of importance. Lifespan of laboratory model organisms can be greatly extended by genetic and environmental interventions, which also improve health and function during aging (Clancy et al, 2001; Lucanic, Lithgow, & Alavez, 2013; Xiao et al, 2013). Many of these interventions target components of the nutrient‐sensing network and decrease the activity of IGF/insulin and/or TOR signalling (Fontana, Partridge, & Longo, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…As aging is the major risk factor for multiple pathologies, including cardiovascular diseases, neurodegenerative disorders and cancer (Niccoli & Partridge, 2012), finding interventions that can increase health during aging is of importance. Lifespan of laboratory model organisms can be greatly extended by genetic and environmental interventions, which also improve health and function during aging (Clancy et al, 2001; Lucanic, Lithgow, & Alavez, 2013; Xiao et al, 2013). Many of these interventions target components of the nutrient‐sensing network and decrease the activity of IGF/insulin and/or TOR signalling (Fontana, Partridge, & Longo, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Under laboratory settings, the lifespan of D. melanogaster has been successfully increased by genetic manipulations (Clancy et al., 2001; Hwangbo, Gershman, Tu, Palmer & Tatar, 2004; Kapahi et al., 2004; Lin, Seroude & Benzer, 1998; Orr & Sohal, 1994; Parkes et al., 1998; Sun, Folk, Bradley & Tower, 2002; Tatar et al., 2001), dietary interventions (Chapman & Partridge, 1996; Grandison, Piper & Partridge, 2009; Lee et al., 2014; Magwere, Chapman & Partridge, 2004; Mair, Goymer, Pletcher & Partridge, 2003; Min & Tatar, 2006), and pharmacological treatments (Bjedov et al., 2010; Danilov et al., 2013; Wang et al., 2013). These findings are similar to those reported in other model organisms and highlight the important role of nutrient sensing, mTOR, NAD/sirtuins, insulin/IGF1 signaling pathways, and other systems in lifespan control (Fontana, Partridge & Longo, 2010; He et al., 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Defective insulin/IGF signaling is also associated with an increased lifespan in several other species. In Drosophila, chico flies that have reduced insulin signaling and flies that have had their insulinlike peptide-producing median neurosecretory cells ablated experience an increase in lifespan (Broughton et al 2005;Clancy et al 2001). Overexpression of dFOXO, a homolog of DAF-16, has also been shown to increase lifespan in flies (Giannakou et al 2004;Hwangbo et al 2004).…”
Section: Introductionmentioning
confidence: 99%