Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?

Wu, Baiyun; Yan, Jiai; Yang, Ju; Xia, Yanping; Li, Dan; Zhang, Feng; Cao, Hong

doi:10.14336/ad.2022.0117

Cited by 10 publications

(7 citation statements)

References 95 publications

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“…Gut microbiota is a crucial mediator of numerous physiological processes in humans [ 386 , 387 ]. Diseases can develop as a result of dysbiosis, which causes dysfunction of the intestinal barrier and alters intercellular/intracellular metabolic pathways and immune responses [ 386 , 388 ].…”

Section: Functional Roles Of Myc In Cancer Cellsmentioning

confidence: 99%

MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products

Chan,

Zhang,

et al. 2024

Aging and disease

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Various diseases, including cancers, age-associated disorders, and acute liver failure, have been linked to the oncogene, MYC . Animal testing and clinical trials have shown that sustained tumor volume reduction can be achieved when MYC is inactivated, and different combinations of therapeutic agents including MYC inhibitors are currently being developed. In this review, we first provide a summary of the multiple biological functions of the MYC oncoprotein in cancer treatment, highlighting that the equilibrium points of the MYC/MAX, MIZ1/MYC/MAX, and MAD (MNT)/MAX complexes have further potential in cancer treatment that could be used to restrain MYC oncogene expression and its functions in tumorigenesis. We also discuss the multifunctional capacity of MYC in various cellular cancer processes, including its influences on immune response, metabolism, cell cycle, apoptosis, autophagy, pyroptosis, metastasis, angiogenesis, multidrug resistance, and intestinal flora. Moreover, we summarize the MYC therapy patent landscape and emphasize the potential of MYC as a druggable target, using herbal medicine modulators. Finally, we describe pending challenges and future perspectives in biomedical research, involving the development of therapeutic approaches to modulate MYC or its targeted genes. Patients with cancers driven by MYC signaling may benefit from therapies targeting these pathways, which could delay cancerous growth and recover antitumor immune responses.

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Section: Functional Roles Of Myc In Cancer Cellsmentioning

confidence: 99%

MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products

Chan,

Zhang,

et al. 2024

Aging and disease

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“…321 Acarbose has been hypothesized to extend life span by controlling gut microbiota, thus reducing inflammatory reactions and therefore diminishing the risk of mitochondrial disorders and telomere attrition. 322 4.2. Senolytic Drugs.…”

Section: Antiaging Drugsmentioning

confidence: 99%

“…It was recently reported to exhibit promise as an antiaging drug by increasing lifespan in mice , and relieve certain age-related pathologies . Acarbose has been hypothesized to extend life span by controlling gut microbiota, thus reducing inflammatory reactions and therefore diminishing the risk of mitochondrial disorders and telomere attrition …”

Section: Antiaging Drugsmentioning

confidence: 99%

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

Tenchov,

Sasso,

Wang

et al. 2024

ACS Chem. Neurosci.

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Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collection to analyze the publication landscape of recent research related to antiaging strategies and treatments. We review the recent advances and delineate trends in research headway of antiaging knowledge and practice across time, geography, and development pipelines. We further assess the state-of-theart antiaging approaches and explore their correlations with age-related diseases. The landscape of antiaging drugs has been outlined and explored. Well-recognized and novel, currently evaluated antiaging agents have also been summarized. Finally, we review clinical applications of antiaging products with their development pipelines. The objective of this review is to summarize current knowledge on preventive strategies and treatment remedies in the field of aging, to outline challenges and evaluate growth opportunities, in order to further efforts to solve the problems that remain.

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“…Z. Sun et al., 2020; Haoran Wu et al., 2022) and acarbose (Harrison et al., 2019; B. Wu et al., 2022), along with the nonsteroidal anti‐inflammatory drug—acetylsalicylic acid.…”

Section: “New” Hallmarks Of Aging—longevity Perspectivementioning

confidence: 99%

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Todorova,

Savova,

Mihaylova

et al. 2024

Food Frontiers

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The revolution in aging research through the past decade has driven the progress in interventions that promote longevity. Dissection of the “old” hallmarks of aging has provided solid data for the definition of at least three “new” ones, opening avenues for the development of novel hallmark‐targeted pro‐longevity approaches. The quest for geroprotectors is of enormous interest with the ultimate goal of finding the alchemical stone that induces healthy aging and increases lifespan, pushing the limits of human longevity or even uncovering the absence of such limits. Several of the well‐appreciated geroprotectors that are recognized as longevity promoters are of natural origin such as metformin, resveratrol, aspirin, and spermidine. As the search for pharmacological modulators of healthspan and lifespan continues, numerous studies are focusing on the potential of plant secondary metabolites. The current review attempts to critically assess the available interventions and the breakthrough discoveries in the field of longevity research over the past decade. Correspondingly, novel approaches targeting the hallmarks of aging have been outlined, and the future goals in longevity research have been enlightened. Special emphasis has been placed on the potential of plant‐derived compounds as pro‐longevity agents.

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Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?

Cited by 10 publications

References 95 publications

MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products

MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

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