Extension of the prepatent period of Fasciola hepatica in infected animals following treatment with triclabendazole

Disruption of egg formation by Fasciola hepatica following treatment in vivo with triclabendazole in the sheep host

“…Büscher et al, 1987;Maes et al, 1988Maes et al, , 1990Hanna et al, 2006); stunting and lower egg production have also been described in adult flukes that survive sub-therapeutic doses of active drugs (e.g. Malone et al, 1982Malone et al, , 1984Büscher et al, 1987;Lucas, 1967;Maes et al, 1988). These results have important repercussions for the epidemiology of fascioliasis, in relation to pasture contamination by fluke eggs.…”

“…Stunting, delayed development and consequent extension of the pre-patent period in immature flukes surviving drug treatment have been observed, even with less active drugs (e.g. Büscher et al, 1987;Maes et al, 1988Maes et al, , 1990Hanna et al, 2006); stunting and lower egg production have also been described in adult flukes that survive sub-therapeutic doses of active drugs (e.g. Malone et al, 1982Malone et al, , 1984Büscher et al, 1987;Lucas, 1967;Maes et al, 1988).…”

“…Also, drug treatment of immature fluke infections is known to affect subsequent reproductive development and egg production (Lucas, 1967;Presidente and Knapp, 1972;Stammers, 1975Stammers, , 1976Malone et al, 1982Malone et al, , 1984Yazwinski et al, 1985;Büscher et al, 1987;Maes et al, 1988Maes et al, , 1990Hanna et al, 2006).…”

Efficacy of an experimental fasciolicide against immature and mature Fasciola hepatica in artificially infected calves

“…It is also important to note that compound alpha overcomes the problem of lack of activity shown against immature stages by older fasciolicides such as meniclofolan, nitroxinil, rafoxanide, albendazole, closantel and clorsulon, among others (Cordero del Campillo and Rojo Va´zquez 1999). With regard to fluke length, Buscher et al (1987) have mentioned the capability of certain drugs to affect the size and retard the development of the parasite. In this study, the average fluke length from the treated groups was always slightly smaller than that of the untreated control groups.…”

Influence of barley supplement on plasma concentration of triclabendazole metabolites in sheep

“…Sublethal doses of tcbz would reduce their flukicide efficacy and may further contribute to the development of anthelmintic resistance. Büscher and others (1987) showed that sublethal doses of tcbz retarded F hepatica development, resulting in the extension of the prepatent period and smaller sized flukes. On the other hand F hepatica strains resistant to tcbz have recently been reported (Overend and Bowen 1995).…”