Extensive anal condylomatosis: prognosis in relation to viral and host factors

Sarzo, Giacomo; Mistro, Annarosa Del; Finco, C; Frayle, Helena; Marino, Filippo; Franzetti, Marzia; Ferrara, Roberto; Mistrangelo, Massimiliano; Savastano, Silvia; Vecchiato, Marco; Merigliano, Stefano

doi:10.1111/j.1463-1318.2009.01902.x

Cited by 10 publications

(9 citation statements)

References 23 publications

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“…6,8 a wide surgical excision with 1-cm macroscopically negative margins is presently considered the most appropriate treatment for this type of lesion. 14,15 the incidence of malignant transformation of GCa is very high and varies from 30% to 56%. 6,16 Consequently, radical surgical excision that allows complete histologic examination is mandatory for these patients: any additional therapies will be scheduled in relation to the presence of tumor, infiltration of surrounding tissues, or involvement of resection margins.…”

Section: Discussionmentioning

confidence: 99%

Circumferential Anal Giant Condyloma Acuminatum

Guttadauro¹,

Chiarelli²,

Macchini³

et al. 2015

Diseases of the Colon &Amp; Rectum

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Section: Discussionmentioning

confidence: 99%

Circumferential Anal Giant Condyloma Acuminatum

Guttadauro¹,

Chiarelli²,

Macchini³

et al. 2015

Diseases of the Colon &Amp; Rectum

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“…Furthermore, human leukocyte antigen (HLA)-mismatching between the donor and the recipient and T-cell depletion can delay immune recovery. Ongoing immunosuppression in patients undergoing transplantation provides fertile ground for untamed proliferation of the HPV virus, which leads to a higher chance of dissemination, local invasion, and oncogenesis [ 2 , 3 , 11 , 12 ]. To date, no definitive therapeutic strategies have been established [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

Giant anal condyloma (giant condyloma acuminatum of anus) after allogeneic bone marrow transplantation associated with human papillomavirus: a case report

et al. 2015

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IntroductionCondyloma acuminatum are caused by human papillomavirus. Giant condyloma acuminatum is a locally invasive, destructive, and large sized mass. Risk factors for the development of giant condyloma acuminatum include an immunodeficient state, such as human immunodeficiency virus infection, post-organ transplantation, or post-allogeneic bone marrow transplantation. However, reports of giant condyloma after bone marrow transplantation are extremely rare (0.3 to 1.3%). The standard treatment for giant condyloma acuminatum is recommended as wide surgical resection due to its high rate of success and low rate of recurrence.Case presentationA 31-year-old Korean man presented to our hospital with anal discomfort for more than one month due to a protruding mass. He had a history of BCR-ABL-positive acute lymphoblastic leukemia and had undergone an allogenic stem cell transplantation. Gross findings revealed a large perianal cauliflower-like mass over 7cm in size with invasion of the anal orifice. He was diagnosed with giant anal condyloma occurring after an allogeneic bone marrow transplantation. However, we achieved successful treatment using a combination of topical podophyllin and cryotherapy and transanal surgical excision, followed by bleomycin irrigation.ConclusionsWe report an extremely rare case of giant condyloma acuminatum of anus due to human papillomavirus type six in a patient with acute lymphoblastic leukemia following an allogeneic bone marrow transplantation. The tumor was successfully treated with a combination of topical podophyllin and cryotherapy and transanal surgical excision, followed by bleomycin irrigation.

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“…When treatment is considered, the first choice is surgery in which a radical resection should be achieved [3, 5, 8, 9]. Despite radical or wide local excision the tumour still has a high recurrence rate of 50% [3].…”

Section: Discussionmentioning

confidence: 99%

Intra-Abdominal Localisation of a Buschke-Lowenstein Tumour: Case Presentation and Review of the Literature

Wester

Hutten

Krikke

et al. 2013

Case Reports in Transplantation

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Giant condyloma acuminatum or Buschke-Lowenstein tumour is a very rare disease which usually is located in the genital, anorectal, and perianal regions. It is regarded as a type of verrucous carcinoma occurring on anogenital mucosal surfaces where it is locally invasive but displays a benign cytology. We describe a case of a 24-year-old woman with persisting condyloma acuminata progressing to a large intra-abdominal Buschke-Lowenstein tumour. To our knowledge such an advanced stage has only been reported once before. The severity and extent of the tumour both determine the treatment and patient outcome. Treatment was impeded by cachexia, an immunosuppressive state after kidney transplantation and difficulties in establishing a reliable diagnose. Interferon treatment was started which initially led to tumour reduction but was complicated by an interferon-induced pancreatitis, pneumonia, and fasciitis necroticans resulting in death. We present a literature overview on the treatment options for a Buschke-Lowenstein tumour, with emphasis on interferon therapy, with all the advantages and disadvantages.

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Extensive anal condylomatosis: prognosis in relation to viral and host factors

Abstract: Radical resection resulted in a favourable clinical course. Typing of HPV sequences in the management of patients affected by extensive anal condylomatosis may be useful.

Cited by 10 publications

References 23 publications

Circumferential Anal Giant Condyloma Acuminatum

Circumferential Anal Giant Condyloma Acuminatum

Giant anal condyloma (giant condyloma acuminatum of anus) after allogeneic bone marrow transplantation associated with human papillomavirus: a case report

Intra-Abdominal Localisation of a Buschke-Lowenstein Tumour: Case Presentation and Review of the Literature

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