Extensive and Partial Protein Hydrolysate Preterm Formulas: The Effect on Growth Rate, Protein Metabolism Indices, and Plasma Amino Acid Concentrations

Abstract

This study suggests that experimental EH and PH are at least nutritionally equivalent to SFs.

Higher urinary excretion of essential amino acids in preterm infants fed protein hydrolysates

“…Reviewing most of the nitrogen balance studies, Rigo et al showed that, in preterm infants fed hydrolysed formula compared to those fed conventional preterm formula, nitrogen absorption and protein efficiency decreased significantly from 90.7±3.3 to 84.0±4.0% and from 77.7±6.4 to 74.0±6.9%, respectively 26. More recently, studies have shown that preterm infants fed with modern protein hydrolysate formulae exhibit more adequate nitrogen retention after correction for intake, a tendency towards higher calcium absorption and similar growth 19,27. Nevertheless, in the randomized pilot study of Picaud et al 19 infants assigned to a partially hydrolysed formula had, at theoretical term, lower body weight (−366 g; p =0.04); the difference was the result of a significantly slower weight gain from inclusion to discharge (28.1±5.1 g/d vs 32.8±2.4 g/d, p =0.03), probably related to the lower amount of nitrogen retained in hydrolysed formula‐fed infants.…”

Higher urinary excretion of essential amino acids in preterm infants fed protein hydrolysates

“…Reviewing most ofthe nitrogen balance studies, Rigo et al showed that, in preterm infants fed hydrolysed formula compared to those fed conventional preterm formula, nitrogen absorption and protein efficiency decreased significantly fi-om 90.7 ±3.3 to 84.0 ±4.0% and from 77.7 ±6.4 to 74.0 ±6.9%, respectively [26]. More recently, studies have shown that preterm infants fed with modern protein hydrolysate formulae exhibit more adequate nitrogen retention after correction for intake, a tendency towards higher calcium absorption and similar growth [19,27]. Nevertheless, in the randomized pilot study of Picaud et al [19] infants assigned to a partially hydrolysed formula had, at theoretical term, lower body weight ( -366 g; p = 0.04); the difference was the result of a significantly slower weight gain ft'om inclusion to discharge (28.1 ±5.1 g/d vs 32.8±2.4 g/d, p = 0.03), probably related to the lower amount of nitrogen retained in hydrolysed formula-fed infants.…”

Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Timing of Introduction of Complementary Foods, and Hydrolyzed Formulas

“…However, using the criteria of a 2006 Cochrane review, 41 only 14 randomized or quasirandomized (eg, using alternation) trials in term infants compared the use of partially or extensively hydrolyzed formula with the use of human milk or an adapted cow milk formula. [42][43][44][45][46][47][48][49][50][51][52][53][54][55] All of these trials have followed up with at least 80% of study participants. It is important to note that none of these studies reported any adverse effects, including any adverse effect on infant growth.…”