Extensive carcinoma cuniculatum of the mandible

Shay, Sophie; Choy, Winward; Christensen, Robert E.; John, Maie A. St.

doi:10.1016/j.amjoto.2015.01.002

Cited by 13 publications

(17 citation statements)

References 23 publications

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“…The most common clinical presentation was pain,3910262730313335 followed by ulceration,13913262829303233 swelling,913262930323336 and induration 91336. This differs from the clinical presentation of OSCC, which may vary according to the affected intraoral subsite and for which pain is not the most common feature.…”

Section: Discussionmentioning

confidence: 84%

“…The search strategy retrieved 229 hits; 27 were relevant for our study, of which 10 studies were excluded because they were not written in the English language81617181920 or they did not contain any oral cases 21222324. This resulted in a total of 17 articles that were included in the systematic review,1391013252627282930313233343536 which presented 43 cases (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

“…The size of oral CC ranged from 1 to 6 cm; however, this range was derived from only 7 cases,3132526283436 which is insufficient for a conclusive estimation of the average size of these tumors.…”

Section: Discussionmentioning

confidence: 99%

“…The duration of the lesion was recorded in 90.7% of the cases,13910132528313233343536 with a mean of 19.5 months. This relatively long duration most likely indicates the slowly growing clinical course of oral CC,9103336 which matches VC; however, this finding is in contrast to the behavior of OSCC, which shows a rapidly growing course 11…”

Section: Discussionmentioning

confidence: 99%

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Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review

2018

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PurposeOral carcinoma cuniculatum is a rare well-differentiated variant of oral squamous cell carcinoma. The purpose was to systematically review its unique features to differentiate it from other variants as verrucous carcinoma, papillary squamous cell carcinoma and well-differentiated squamous cell carcinoma.Materials and MethodsA systematic review was performed using MEDLINE, Dentistry and Oral Sciences Source and PubMed databases and any existing articles related to the research subject missed in the search strategy to screen ones reporting cases occurring exclusively in the oral cavity in English literature. Variables analyzed included clinical, etiologic, imaging, histopatholgical features, treatment, follow-up and survival rates.ResultsFrom 229 hits, 17 articles with 43 cases were included in the systematic review. Clinically it showed a female predilection with pain and/or ulceration of a relatively long duration and exudation being the most common symptoms. Histologically, it showed more endophytic features comprising well-differentiated squamous epithelium with absent or minimal cytological atypia and multiple keratin filled crypts or cuniculus. Inflammatory stromal reaction and discharging abscesses were reported in most of the cases. Bone destruction was predominant in most imaging features. Complete surgical resection with a safety margin was the treatment of choice in most of the cases with few recorded recurrence cases.ConclusionApprehensive knowledge of oral carcinoma cuniculatum unique features is essential to avoid its misdiagnosis and provide proper treatment especially for recurrent cases.

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Section: Discussionmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review

2018

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“…No evidence of conventional squamous cell carcinoma was observed in any of these tissue samplings. These findings evoked consideration of carcinoma cuniculatum, a peculiar variant of well-differentiated squamous cell carcinoma in which neoplastic epithelium resembling that of surface alveolar mucosa or an epidermoid cyst invades bone [2][3][4][5][6][7][8][9] . Lesional epithelium is invasive but characteristically appears non-neoplastic or minimally atypical, confounding definitive diagnosis.…”

mentioning

confidence: 99%

Carcinoma cuniculatum: radiographically malignant, histopathologically benign

Slater

2018

Oral Surgery

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Cuneiform (cuniculatum) variant of oral squamous cell carcinoma revisited: Presentation of two cases and literature review of a rare entity

et al. 2022

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Background Oral carcinoma cuniculatum (OCC) is a rare, locally aggressive tumor, which tends to invade underlying bone. We present two cases of OCC, one demonstrating invasion of the mandible and the other limited to the tongue. Methods An 87‐year‐old male presented with a right‐sided buccogingival lesion. Biopsy results led to a diagnosis of verrucous hyperplasia, which was later revised to OCC. Additionally, a 94‐year‐old female presented with a left lateral tongue lesion. A biopsy showed in‐situ and invasive keratinizing squamous cell carcinoma that was later defined as a soft tissue OCC. Results Following surgical resection, the diagnosis of OCC was established in both patients. We provide a comprehensive literature review of OCC in the context of both case presentations. Conclusions OCC is a rare entity, which has a tendency to be misdiagnosed. We emphasize the importance of recognizing the common features of OCC in order to aid in accurate diagnosis.

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Extensive carcinoma cuniculatum of the mandible

Cited by 13 publications

References 23 publications

Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review

Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review

Carcinoma cuniculatum: radiographically malignant, histopathologically benign

Cuneiform (cuniculatum) variant of oral squamous cell carcinoma revisited: Presentation of two cases and literature review of a rare entity

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