Extensive cutaneous metastases of pancreatic adenocarcinoma: a case report and review of the literature

Kotsantis, Ioannis; Economopoulou, Panagiota; Dritsakos, K.; Oikonomopoulos, Nikolaos; Bakogeorgos, Marios; Rapti, Cleopatra; Kentepozidis, Nikolaos

doi:10.1002/ccr3.737

Cited by 12 publications

(11 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skin lesions are most commonly found in the umbilical region, as a result of direct spread of peritoneal carcinomatosis through the remnant of the obstructed umbilical vein (“Sister Joseph’s nodule”) [ 5 ]. On the contrary, no more than 34 cases of extra-umbilical cutaneous metastases from pancreatic adenocarcinoma have been described so far in the literature, located in several different sites such as the face, neck, scalp, chin, axilla, chest, abdomen, buttocks, scrotum, or even labia majora [ 21 , 22 ]. Interestingly, distant metastases from pancreatic adenocarcinoma exclusively involving the deeper layers of the soft tissue (subcutis and skeletal muscle) are even more rare.…”

Section: Discussionmentioning

confidence: 99%

Solitary Soft-Tissue Metastasis of a Pancreatic Adenocarcinoma 2 Years After Curative Resection: Report of a Rare Case and a Literature Review

et al. 2022

View full text Add to dashboard Cite

Patient: Female, 74-year-old Final Diagnosis: Soft tissue metastasis from pancreatic adenocarcinoma Symptoms: Palpable, hard and painful mass, with rapid growth, located in the posterior aspect of the upper left thigh Medication: — Clinical Procedure: — Specialty: Surgery Objective: Rare disease Background: Soft-tissue metastases from a primary carcinoma are rare lesions. They often are the first clinical manifestation of a previously unknown malignancy of an advanced stage, but may also be solitary in a setting of a recurrent disease. Generally, they are associated with poor prognosis and may be the source of diagnostic confusion both clinically and pathologically. The primary location of the malignancy is usually lung, breast, kidney, or colon. Soft-tissue metastases from a pancreatic adenocarcinoma are extremely rare. A few cases involving the skin have been described in the literature, and solitary metastasis to the deep soft-tissue (eg, subcutis and skeletal muscle) was reported less than 10 times. Case Report: We report the case of a 74-year-old woman who presented with late-onset (recurrent disease), solitary, subcutaneous metastasis in the posterior aspect of the left thigh, deriving from a pancreatic head adenocarcinoma, 2 years after initial treatment with R0 resection (pancreaticoduodenectomy) and adjuvant chemotherapy. We emphasize the rarity of this entity, review the literature, and discuss treatment options. Conclusions: Solitary soft-tissue metastasis from a pancreatic adenocarcinoma after initial curative treatment is very rare. Although hematogenous spread from a pancreatic adenocarcinoma generally has a very poor prognosis, treatment should be individualized according to the patient’s history, general condition, and symptoms and the clinical setting in relation to the primary disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Solitary Soft-Tissue Metastasis of a Pancreatic Adenocarcinoma 2 Years After Curative Resection: Report of a Rare Case and a Literature Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Cutaneous metastasis from pancreatic cancer are a rare finding, the most frequent reported site being the umbilical region—the Sister Mary Joseph nodule. Other sites have also been reported—face, neck, scalp, temple, chin, axilla, chest, abdomen, buttocks or even scrotum [ 28 ].…”

Section: Cutaneous Manifestations In Pancreatic Diseasesmentioning

confidence: 99%

Cutaneous Manifestations in Pancreatic Diseases—A Review

Miulescu

Balaban

Şandru

et al. 2020

JCM

View full text Add to dashboard Cite

Pancreatic pathology, comprising acute and chronic pancreatitis, autoimmune pancreatitis and pancreatic neoplasms, primarily presents with gastrointestinal symptoms and signs; however, it is well recognized that it can also associate a wide range of extra-digestive features. Among these systemic manifestations, cutaneous involvement plays an important role both as a diagnostic clue for the pancreatic disease itself and serving as a prognostic factor for the severity of the condition. Recognition of these cutaneous signs is, however, far from being satisfactory, all the more as some of them are relatively rare. In the current review, we discuss skin involvement in pancreatic diseases, referring to pancreatic panniculitis, cutaneous hemorrhagic manifestations, skin metastasis, acanthosis nigricans, livedo reticularis, necrolytic migratory erythema and cutaneous fistula. We highlight the clinical characteristics, treatment and prognostic value of these lesions. Better awareness among medical specialties other than dermatology is needed for detection of the skin clues associated with pancreatic pathology.

show abstract

Section: Introductionmentioning

confidence: 99%

“…There is disagreement as to whether these lesions represent cutaneous or deeper‐seated peritoneal lesions that spread to the umbilicus 13 . Other reported sites of cutaneous metastases include the face, neck, scalp, temple, chin, axilla, chest, abdomen, buttocks, scrotum, and labia 7,11,14,15 . Clinically, a cutaneous metastasis most commonly presents as a red nodule or mass but may also present as a plaque or swelling of the skin 14 …”

Section: Introductionmentioning

confidence: 99%

“…13 Other reported sites of cutaneous metastases include the face, neck, scalp, temple, chin, axilla, chest, abdomen, buttocks, scrotum, and labia. 7,11,14,15 Clinically, a cutaneous metastasis most commonly presents as a red nodule or mass but may also present as a plaque or swelling of the skin. 14 Herein, we report on a large single-institution cohort of patients with PC and cutaneous metastases and provide a detailed summary of clinical descriptors and outcomes and place these data in the context of the reported literature.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes

Mehta

Rao

et al. 2022

Cancer Medicine

View full text Add to dashboard Cite

Background Cutaneous metastases in pancreatic cancer (PC) are rare. Herein, we evaluate the clinical, genomic, and other descriptors of patients with PC and cutaneous metastases. Methods Institutional databases were queried, and clinical history, demographics, PC cutaneous metastasis details, and overall survival (OS) from cutaneous metastasis diagnosis were abstracted. OS was estimated using Kaplan–Meier methods. Results Forty patients were identified, and median age (Q1–Q3, IQR) of PC diagnosis was 66.0 (59.3–72.3, 12.9) years. Most patients had Stage IV disease at diagnosis ( n = 26, 65%). The most common location of the primary tumor was the tail of the pancreas ( n = 17, 43%). The most common cutaneous metastasis site was the abdomen ( n = 31, 78%), with umbilical lesions occurring in 74% ( n = 23) of abdominal lesions. The median OS (95% CI) was 11.4 months (7.0, 20.4). Twenty‐three patients had umbilical metastases (58%), and 17 patients had non‐umbilical metastases (43%). The median OS (95% CI) was 13.7 (7.0, 28.7) months in patients with umbilical metastases and 8.9 (4.1, Not reached) months in patients with non‐umbilical metastases ( p = 0.1). Sixteen of 40 (40%) patients underwent somatic testing, and findings were consistent with known profiles. Germline testing in 12 (30%) patients identified pathogenic variants in patients: CHEK2 , BRCA1, and ATM. Conclusion Cutaneous metastases from PC most frequently arise from a pancreas tail primary site and most frequently occur in the umbilicus. Cutaneous metastases may generally be categorized as umbilical or non‐umbilical metastases.

show abstract

Extensive cutaneous metastases of pancreatic adenocarcinoma: a case report and review of the literature

Abstract: Key Clinical MessageHerein, we present the case of a patient with pancreatic cancer and nonumbilical cutaneous metastasis. Patients with pancreatic adenocarcinomas can develop extensive cutaneous metastases involving not only abdominal skin but also other unusual sites such as the scrotum.

Cited by 12 publications

References 26 publications

Solitary Soft-Tissue Metastasis of a Pancreatic Adenocarcinoma 2 Years After Curative Resection: Report of a Rare Case and a Literature Review

Solitary Soft-Tissue Metastasis of a Pancreatic Adenocarcinoma 2 Years After Curative Resection: Report of a Rare Case and a Literature Review

Cutaneous Manifestations in Pancreatic Diseases—A Review

Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes

Contact Info

Product

Resources

About