Extensive Giant Cell Tumour of the Mandible: A Case Report with Review

Central giant cell lesion of the mandible in a 2-year old girl

“…Giant cell lesions of the bone are common in the long bones, but rare in the facial bone, which accounts for only 2%–12% of all giant cell tumors of the body. 1 2 To the best of our knowledge, few case reports have described giant cell lesions of the mandible. 1 2 Furthermore, in recent years, giant cell reparative granuloma has been classified as an osteoclastic giant cell-rich tumor (namely, giant cell lesion of the small bones), which comprises very rare tumor-like lesions consisting of fibrous tissue with hemorrhage, hemosiderin deposits, irregularly distributed giant cells, and reactive bone formation.…”

“… 1 2 To the best of our knowledge, few case reports have described giant cell lesions of the mandible. 1 2 Furthermore, in recent years, giant cell reparative granuloma has been classified as an osteoclastic giant cell-rich tumor (namely, giant cell lesion of the small bones), which comprises very rare tumor-like lesions consisting of fibrous tissue with hemorrhage, hemosiderin deposits, irregularly distributed giant cells, and reactive bone formation. 7 This report presented the case of a giant cell lesion of the small bones of the mandible in a 2-year-old child that was evaluated with MDCT.…”

“…The incidence of giant cell tumors is 2%-12% in the head and neck region; of these cases, 90% affect the posterior mandible, and they usually occur in young adults under 20 years of age. 1 Recently, Jadu et al 16 reported the case of a 31-year-old man with a central giant cell granuloma of the mandibular condyle, and Mohan et al 17 presented a case of a 4-year-old boy with a central giant cell granuloma in the right mandibular region. Therefore, a giant cell lesion in the central area of the mandible in a 2-year-old, as described in this report, is a very rare occurrence.…”

“…Central giant cell lesions of the jaw are relatively uncommon lesions that cause thinning and expansion of the cortical bone. 1 2 Either jaw can be affected, but the mandible is affected more often. Although these lesions are benign, they can be clinically classified as non-aggressive or locally aggressive, and they occasionally recur after treatment with curettage or surgical excision.…”

Insight into the pathogenesis and nature of Central giant cell lesions of the jaws

“…Discussions as to whether all aggressive CGCL lesions of the jaw are within the spectrum of CGCL ( 16 ) or whether subsets represent agnathic variant of the GCT of the long bone persist ( 17 , 18 ).…”