Extensive Juvenile Xanthogranuloma

Hota, Dayanand; Amrani, A.; Kumar, Mritunjay

doi:10.1007/s13312-018-1434-x

Cited by 2 publications

(3 citation statements)

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“…In most children, JXG is limited to the skin and does not require any treatment, however over the past few decades unusual cutaneous and systemic forms have been reported. Accurate diagnosis is necessary to prevent unnecessary invasive diagnostic and therapeutic procedures (9).…”

Section: Discussionmentioning

confidence: 99%

Juvenile Gluteal Xanthogranuloma: A Rare Case

Bhatia,

Khandekar,

Rammohan

2023

Preprint

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Juvenile Xanthogranulomas (JXGs) are rare, benign lesions that belong to the large group of non-Langerhans cell histiocytosis, often affecting infants and younger children. JXG usually presents with 1 or more erythematous or yellowish nodules that are most commonly located on the head or neck. On the contrary, we present a rare case of juvenile xanthogranuloma which presented as a large swelling in the gluteal region-a location that has been rarely described in literature. The baby underwent excision of gluteal swelling. Histopathology demonstrated a lymphohistiocytic lesion characterized by proliferation of mononuclear medium-sized histiocytes along with admixed multinucleated giant cells, variably lipidized xanthomatous and Touton-type giant cells. Immunohistochemistry showed immunopositivity for CD68 (Diffuse) and CD4 (Diffuse). Cutaneous JXGs are usually self-limiting and do not require treatment, unless large and causing functional impairment as seen in the case described. Systemic cases may even warrant chemotherapy. Case Report History-A 1-month-old child was brought with insidious onset right gluteal swelling over one month. The swelling was non-tender, with reddish discoloration of the overlying skin.

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Section: Discussionmentioning

confidence: 99%

Juvenile Gluteal Xanthogranuloma: A Rare Case

Bhatia,

Khandekar,

Rammohan

2023

Preprint

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“… 1 , 2 Multiple JXGs most commonly occur either as congenital lesions or within the first 6 months of life. 1 , 5 There is no consensus on the number of lesions required to use the term disseminated or eruptive JXGs. Of note, a report from Selcen Kundak et al 2 described patients with eruptive JXGs as having ⩾6 lesions.…”

Section: Discussionmentioning

confidence: 99%

“…3 Early recognition is crucial in order to prevent secondary glaucoma, vision loss and complications related to neovascularization since ocular lesions do not tend to resolve spontaneously. 2 , 3 , 5 – 13 Risk factors for ocular involvement included multiple skin lesions, micronodular form of JXGs, newly diagnosed JXG and age 2 years or younger. 2 , 4 , 11 In a recent review in Pediatric Dermatology, eye examination was recommended for patients with multiple JXG but unnecessary for those with single cutaneous JXG.…”

Section: Discussionmentioning

confidence: 99%

Disseminated juvenile xanthogranulomas with ocular involvement: A case report and literature review

Maalouf

Aouane

Hamel

et al. 2022

SAGE Open Medical Case Reports

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Cutaneous juvenile xanthogranuloma is an uncommon disorder usually arising during infancy. Systemic involvement of juvenile xanthogranuloma remains rare, and there are no published guidelines to date on screening extracutaneous manifestations in these patients. Ocular involvement is the most common extracutaneous manifestation of juvenile xanthogranuloma. We present the case of an infant with disseminated juvenile xanthogranulomas and associated ocular involvement and present a review of literature, focusing on identifying risk factors for ocular and systemic involvement in disseminated cases.

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Extensive Juvenile Xanthogranuloma

Cited by 2 publications

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Juvenile Gluteal Xanthogranuloma: A Rare Case

Juvenile Gluteal Xanthogranuloma: A Rare Case

Disseminated juvenile xanthogranulomas with ocular involvement: A case report and literature review

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