Extensive Paneth cell metaplasia in an ovarian Krukenberg tumor: report of an unusual case and literature review

AlRajban, Waleed A.; Khubrani, Reham; Almalki, Mamdouh Saad; Almassri, Ashraf; Al-Rikabi, Ammar C.

doi:10.1093/jscr/rjy323

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…Esophagus Conventional H&E staining Chen et al, 2015 H&E, light microscopy and electron microscopy Schreiber et al, 1978 H&E, periodic acid-Schiff/Alcian blue Takubo et al, 1995 H&E, Lendrum's Phyloxine-tartrazine stain Thompson et al, 1983 Stomach Periodic acid-Schiff/Alcian blue at pH 2.5 Abraham et al, 2003 H&E, Masson's Trichome, Lendrum's Phyloxine-tartrazine, Periodic acid-Schiff/Alcian blue at pH 2.5 and colloidal iron pH 1.9 staining Albedi et al, 1984 H&E, Periodic acid-Schiff/Alcian blue at pH 2.5, immunostaining for lysozyme Deveci and Deveci, 2004 Immunostaining for lysozyme Gassler et al, 2002 Conventional H&E staining Inada et al, 1997 H&E, Periodic acid-Schiff/Alcian blue at pH 2.5 and Electron microscopy Matsubara, 1977 Immunoelectron microscopy for lysozyme Ohtani and Sasano, 1988 Immunostaining for HD5 and HD6 Ostaff et al, 2015 Conventional H&E staining Rubio et al, 1987 Lysozyme immunostaining Rubio, 2012 Gallbladder Conventional H&E staining Albores-Saavedra et al, 1986 Conventional H&E staining Bae et al, 2002 Electron microscopy, H&E, Periodic acid-Schiff Laitio and Nevalainen, 1975 Conventional H&E staining Sakaki et al, 2000 Ovary Conventional H&E staining Alrajban et al, 2018 Conventional H&E staining Niemiec et al, 1989 Prostate Conventional H&E staining, immunostaining for lysozyme Frydman et al, 1992 Conventional H&E staining Adlakha and Bostwick, 1994 (Shen et al, 2005). Additionally, Paneth-like cells were reported in gastric adenomas and carcinomas (Heitz and Wegmann, 1980;Ito et al, 1986;Caruso et al, 1989;Rubio, 1989).…”

Section: Methods Of Identification Referencesmentioning

confidence: 99%

“…Therefore, the presence of Paneth cells could be a protective mechanism against the pathogenic bacteria in lithogenic bile. Alrajban et al (2018) reported the first PCM in Krukenberg tumors, which represents 1-2% of ovarian tumors and are characterized by the presence of metastatic adenocarcinoma cells. A poorly differentiated carcinoma was observed to contain a mixture of signet ring malignant cells with eosinophilic cytoplasm characteristic of PCM.…”

Section: Appearance Of Paneth Cells In Other Gastrointestinal and Nonmentioning

confidence: 99%

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Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation

et al. 2020

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Paneth cells are residents of the intestinal epithelium. Abnormal appearance of Paneth cells has been widely documented in non-intestinal tissues within the digestive tract and even observed in non-gastrointestinal organs. Although metaplastic Paneth cells are part of the overarching pathology of intestinal metaplasia (IM), only a fraction of intestinal metaplastic lesions contain Paneth cells. We survey literature documenting metaplastic Paneth cells to gain insights into mechanism underlying their etiologic development as well as their potential relevance to human health. A synthesized view from this study suggests that the emergence of metaplastic Paneth cells at extra-intestinal mucosal sites likely represents a protective, anti-bacterial, and inflammatory response evoked by an altered microbial activity.

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Section: Methods Of Identification Referencesmentioning

confidence: 99%

Section: Appearance Of Paneth Cells In Other Gastrointestinal and Nonmentioning

confidence: 99%

Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation

et al. 2020

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“…Ovarian metastasis occurs in approximately 5-10% with female GC and has also been reported in 33-41% of autopsies (9). KT has mostly been reported in case reports (10)(11)(12)(13), with an overall survival (OS) of less than 1 year. As described in case reports and clinical analysis, the main pathological type of KT is signet ring cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

A retrospective study of clinicopathological characteristics and prognostic factors of Krukenberg tumor with gastric origin

Lin¹,

Han²,

Meng³

et al. 2022

J Gastrointest Oncol

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Background: Krukenberg tumor (KT) of gastric origin has a poor prognosis. The present study of KTs are mainly case reports and clinical analysis with few samples. Therefore, it is urgent to explore the clinicopathologic characteristics of KTs through large sample studies. To improve the understanding of the clinical diagnosis and treatment of KT, this paper retrospectively analyzed 10 years of gastric cancer (GC) database data, including clinicopathological and prognostic features, aiming to provide a clinical reference for the diagnosis and treatment of the tumor. Methods:The clinicopathological characteristics, treatments, and survival data were collected and analyzed from 130 patients with KTs of GC. Clinicopathological data included clinical manifestations, laboratory findings, imaging reports, pathology and immunohistochemistry (IHC) reports. We collected treatment regimens information on whether they had undergone surgery and chemotherapy and performed survival follow-up. Univariate and multivariate analysis were used to investigate the risk factors of KTs with gastric origin. Results:The median age of the patients was 41 years. A total of 63.1% of patients had synchronous ovarian metastasis, 70.8% had bilateral ovarian metastasis, 68.5% had peritoneum metastasis, and 98.5% had pathologically poorly differentiated adenocarcinoma. The positive rate of human epidermal growth factor receptor 2 (HER-2) was 1.8%. The follow-up rate was 90.8%, and the median overall survival (mOS) of ovarian metastasis was 13.0 months. Univariate analysis showed statistically significant prognostic factors including menstrual status, size of the gastric lesions and ovarian metastases, number of lymph node metastasis, interval to ovarian metastasis, resection of gastric lesions, peritoneal metastasis, oophorectomy, chemotherapy after ovarian metastases, two-drug regimen chemotherapy, albumin, serum cancer antigen 125 (CA-125) levels, platelet count, D-dimer, fibrinogen, and high pretreatment platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII). Fibrinogen [hazard ration (HR) =0.483; 95% confidence interval (CI): 0.300-0.777; P=0.003], size of ovarian metastasis (HR =1.808; 95% CI: 1.178-2.776; P=0.007), chemotherapy after ovarian metastasis (HR =0.195; 95% CI: 0.101-0.379; P=0.000), peritoneal metastasis (HR =2.742; 95% CI: 1.606-4.682; P=0.000) and oophorectomy (HR =1.720; 95% CI: 1.066-2.778; P=0.026) were independent prognostic factors.Conclusions: GC patients with KTs have some unique clinical features. Hypercoagulable states, peritoneal metastasis, and untimely chemotherapy and oophorectomy might be a worse predictor for KTs derived from gastric origin.

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Extensive Paneth cell metaplasia in an ovarian Krukenberg tumor: report of an unusual case and literature review

Cited by 2 publications

References 9 publications

Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation

Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation

A retrospective study of clinicopathological characteristics and prognostic factors of Krukenberg tumor with gastric origin

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