Extensive resection of the small intestine

Weckesser, Elden C.; Chinn, Austin B.; Scott, Murray W; Price, Jackson

doi:10.1016/0002-9610(49)90312-8

Cited by 46 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is excellent evidence that the frequency of diabetes in the obese adult is three to four times as great as in the nonobese adult (12). Similar observations in the controlled and uncontrolled intestinal shunt have been reported by other invesitgators (4,5).…”

Section: Commenfssupporting

confidence: 90%

“…The changes subsequently to be described in the liver .. i i i !, ing a modest amount of protein and fat will provide the lowest fecal nitrogen and fat excretion (5). Although we attempted to regulate their diets in this manner, these patients were not able or willing to follow our instructions.…”

Section: Electrolytes No Consistent or Unphysiologicmentioning

confidence: 99%

“…The usual reasons for the uncontrolled bowel resections are mesenteric artery occlusion with infarcted intestine, volvulus, extensive neoplastic disease, ileitis and adhesions. An enormous amount of clinical and laboratory experience has been accumulated that man can survive the sacrifice of most of his intestine (1)(2)(3)(4)(5).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Metabolic observations in patients with jejunocolic shunts

Payne

DeWind

Commons

1963

The American Journal of Surgery

274

View full text Add to dashboard Cite

Section: Commenfssupporting

confidence: 90%

Section: Electrolytes No Consistent or Unphysiologicmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic observations in patients with jejunocolic shunts

Payne

DeWind

Commons

1963

The American Journal of Surgery

274

View full text Add to dashboard Cite

“…From these case series it became obvious that the small bowel was not merely a “uniform tube” and that different regions (e.g. duodenum, jejunum, ileum) had different absorptive capacities and selectivity for nutrients and other molecules (Weckesser et al, 1949). These findings led to the development of deliberate intestinal bypasses (e.g.…”

Section: What Are the Mechanisms Behind The Effectiveness Of Bariamentioning

confidence: 99%

Bile acids and bariatric surgery

Albaugh

Banan

Ajouz

et al. 2017

Molecular Aspects of Medicine

116

View full text Add to dashboard Cite

Bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), are the most effective and durable treatments for morbid obesity and potentially a viable treatment for type 2 diabetes (T2D). The resolution rate of T2D following these procedures is between 40-80% and far surpasses that achieved by medical management alone. The molecular basis for this improvement is not entirely understood, but has been attributed in part to the altered enterohepatic circulation of bile acids. In this review we highlight how bile acids potentially contribute to improved lipid and glucose homeostasis, insulin sensitivity and energy expenditure after these procedures. The impact of altered bile acid levels in enterohepatic circulation is also associated with changes in gut microflora, which may further contribute to some of these beneficial effects. We highlight the beneficial effects of experimental surgical procedures in rodents that alter bile secretory flow without gastric restriction or altering nutrient flow. This information suggests a role for bile acids beyond dietary fat emulsification in altering whole body glucose and lipid metabolism strongly, and also suggests emerging roles for the activation of the bile acid receptors farnesoid x receptor (FXR) and G-protein coupled bile acid receptor (TGR5) in these improvements. The limitations of rodent studies and the current state of our understanding is reviewed and the potential effects of bile acids mediating the short-and long-term metabolic improvements after bariatric surgery is critically examined.

show abstract

“…This problem has been evaluated by many experimental and clinical studies (Allen, 1987;Paneva-Holevich, 1969;Hunter et al, 1971), and effective primary suturing methods (Bunnell, 1947;Verdan, 1972;Kleinert et al, 1973) and early exercise therapy regimes have been established in recent years. The use of adhesion preventive membranes that are placed between the tendon and surrounding tissue have also been investigated using various materials (Weckesser, 1949;Koth and Sewell, 1955). However, these studies revealed delayed or absent tendon healing.…”

mentioning

confidence: 99%

Development of Polyvinyl Alcohol-Hydrogel (PVA-H) Shields with a High Water Content for Tendon Injury Repair

Kobayashi

Toguchida

Oka

2001

Journal of Hand Surgery

View full text Add to dashboard Cite

The main problem in tendon repair is adhesion formation between the tendon and surrounding tissue. To prevent this, we have developed adhesion preventive shields using polyvinyl alcohol hydrogel (PVA-H) with 90% water content. This implant experiment used the deep flexor tendon of the 3rd toe of the domestic fowl. Injured tendons shielded with PVA-H healed within about 3 weeks without adhesion to the surrounding tissues. Neither breakage of the PVA-H shield itself nor infection or degeneration in the surrounding tissue was observed. These results show that tendon is capable of intrinsic repair, and was able to regenerate using synovial nutrition through the PVA-H. The high water content of PVA-H may be clinically useful and applicable to adhesion preventive shields for tendon repair.

show abstract

Extensive resection of the small intestine

Cited by 46 publications

References 11 publications

Metabolic observations in patients with jejunocolic shunts

Metabolic observations in patients with jejunocolic shunts

Bile acids and bariatric surgery

Development of Polyvinyl Alcohol-Hydrogel (PVA-H) Shields with a High Water Content for Tendon Injury Repair

Contact Info

Product

Resources

About