1984
DOI: 10.1259/0007-1285-57-682-921
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Extensive subcutaneous calcification following injections of pitressin tannate

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Cited by 22 publications
(12 citation statements)
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“…It is likely that the calcification is dystrophic following local tissue injury. In such cases the calcinosis is assumed to be due to the release of alkaline phosphatase from damaged tissues, resulting in an increase in the local pH, thus favoring the precipitation of calcium salts (8). Woods and Kellaway (9) postulated that calcification follows damage to the sweat ducts.…”
Section: Discussionmentioning
confidence: 99%
“…It is likely that the calcification is dystrophic following local tissue injury. In such cases the calcinosis is assumed to be due to the release of alkaline phosphatase from damaged tissues, resulting in an increase in the local pH, thus favoring the precipitation of calcium salts (8). Woods and Kellaway (9) postulated that calcification follows damage to the sweat ducts.…”
Section: Discussionmentioning
confidence: 99%
“…It has been described in a variety of local tissue injuries including repeated trauma, burns, toxic epidermal necrolysis, surgical scars and keloids 1 . Subcutaneous calcification following local injections of radio‐opaque substances, pitressin tannate and corticosteroids has also been recognized 2,3 . In 1980, Sell et al 4 .…”
mentioning
confidence: 99%
“…It is likely that the calcification is dystrophic following local tissue injury 4–6 . In this situation the calcification is assumed to be due to the release of alkaline phosphatase from injured tissues, resulting in an increase in local pH, thus favouring the precipitation of calcium salts 2 . In their original description, Sell et al 4 .…”
mentioning
confidence: 99%
“…Local tissue injury leads to an increase in cell membrane permeability, which allows a cytosolic influx of calcium, in turn exceeding the capacity of mitochondria to sequester calcium and phosphate and causing cytosolic calcium phosphate to precipitate . Furthermore, local tissue damage discharges alkaline phosphatase, increasing local pH and leading to the precipitation of calcium salts . According to Rodriguez‐Cano et al (), in the case of iatrogenic calcinosis cutis, local tissue damage causes phlebitis during briefly high levels of serum and tissue calcium, through which there are repeated trials to insert a peripheral line, and the extravasation of solution into the surrounding tissue may serve as an initiating factor.…”
Section: Discussionmentioning
confidence: 99%