Extensive use of monosodium glutamate: a threat to public health?

Niaz, Kamal; Zaplatić, Elizabeta; Spoor, Jonathan

doi:10.17179/excli2018-1092

Cited by 40 publications

(36 citation statements)

References 19 publications

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“…While having huge benefits to the food industry, the ubiquitous use of this food additive could have negative consequences for public health. 6 In the present study, assessment of cerebellar function revealed deterioration of the motor function in MSG‐treated rats, compared to the control group, manifested by a gradual deterioration in the latency to fall from the retard and usability and longer time to finish walking, with a mean score of 2, by balance beam test. Similar results were reported by Aminuddin et al 49 and Araujo et al 50 In agreement, 51 found that increase the level of MSG in the synaptic cleft region results in excessive glutamate receptor activation with persistent depolarization (excitotoxicity) producing metabolic and functional exhaustion of the affected neurons leading to neural necrosis, cerebellar damage and motor function deterioration.…”

Section: Discussionsupporting

confidence: 47%

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Therapeutic role of adipose tissue–derived stem cells versus microvesicles in a rat model of cerebellar injury

Mazen

Abdel-Fattah

Desoky

et al. 2021

J Cellular Molecular Medi

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Monosodium glutamate (MSG) is a salt originally derived from herb and commonly marketed as a flavour enhancer. 1 It becomes extensively used in canned food, frozen entrees, crackers, processed meats and dietary supplements. It is also found in soaps, cosmetics, infant formula and vaccines. 2 MSG dissociates in solution to glutamate and sodium ions. 1 Glutamate is the foremost excitatory neurotransmitter in the body.Numerous transporters and receptors for glutamate are found in the

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Section: Discussionsupporting

confidence: 47%

“…However, MSG has been tied to obesity and disorders in the respiratory, circulatory, reproductive and nervous systems. 6 , 7 It triggered symptoms, referred to collectively as ‘Chinese restaurant syndrome’ consisting of numbness at the back of the neck and arms, weakness and palpitations. 8 …”

Section: Introductionmentioning

confidence: 99%

Therapeutic role of adipose tissue–derived stem cells versus microvesicles in a rat model of cerebellar injury

Mazen

Abdel-Fattah

Desoky

et al. 2021

J Cellular Molecular Medi

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“…Proinflammatory cytokines may cause the generation of ROS, which may cause an inflammatory response by activating the transcription factor NF- κ B. Then, NF- κ B is translocated into the nucleus and activates a number of inflammatory genes [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Sitagliptin Attenuates the Cognitive Deficits in L‐Methionine‐Induced Vascular Dementia in Rats

Khodir

Faried

Abd-Elhafiz

et al. 2022

BioMed Research International

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Vascular dementia (VaD) is the second most prevalent type of dementia characterized by progressive cognitive deficits and is a major risk factor for the development of Alzheimer’s disease and other neurodegenerative disorders. This study is aimed at determining the potential neuroprotective effect of sitagliptin (STG) on cognitive deficits in L-methionine-induced VaD in rats and the possible underlying mechanisms. 30 adult male Wistar albino rats were divided equally ( n = 10 ) into three groups: control, VaD, and VaD + STG groups. The cognitive performance of the animals was conducted by open field, elevated plus maze, Y-maze, novel object recognition, and Morris water maze tests. Serum homocysteine, TNF-α, IL-6, IL-10, total cholesterol, and triglycerides levels were assessed together with hippocampal MDA, SOD, and BDNF. Histopathological and immunohistochemical assessments of the thoracic aorta and hippocampus (CA1 region) were also performed. Chronic L-methionine administration impaired memory and learning and induced anxiety. On the other hand, STG protected against cognitive deficits through improving oxidative stress biomarkers, inflammatory mediators, lipid profiles, and hippocampus level of BDNF as well as decreasing caspase-3 and GFAP and increasing Ki-67 immunoreactions in the hippocampus. Also, STG improved the endothelial dysfunction via upregulation of aortic eNOS immunoreaction. STG improved the cognitive deficits of L-methionine-induced VaD by its antioxidant, anti-inflammatory, antiapoptotic, and neurotrophic effects. These findings suggest that STG may be a promising future agent for protection against VaD.

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“…Fast food items sold in roadside stalls/restaurants/canteen like momo, chowmein, pasta, and packed noodles are junk foods. Such foods contain a high amount of Monosodium Glutamate (MSG), a flavor enhancer recognized as a health hazard if taken in larger quantities (Niaz, Zaplatic, & Spoor, 2018). Most people prefer such types of foods because of their taste.…”

Section: Introductionmentioning

confidence: 99%

Multinomial Logistic Regression Model for Assessing Factors Associated with Junk Food Consumption of Secondary Level Students

Subedi

Bhusal

2021

Nep. J. Stats.

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Background: Globalization, economic progress, urbanization, and industrialization have ushered in considerable changes in lifestyles and diet regimes. Consumption of junk food has surged at a rapid pace nowadays. In Nepal, there is a lack of sufficient research regarding junk food practices and persuading factors for its consumption, among teenage students. It is a global concern and has threatened the health of many people. Objective: This research aims to explore the factors associated with junk food consumption among students of secondary level in Ratnanagar Municipality of Chitwan. Materials and Methods: A cross-sectional research design consisting of 371 secondary level students, and selection based on primary data collection method by the researchers was used in this study. The data was analyzed using descriptive as well as an inferential statistical method. To find the association of different factors with junk food consumption levels (Low, Moderate, and High) multinomial logistic regression model (MLRM) was used, and the goodness of fit of the model was assessed. Results: The fitted MLRM satisfied the criteria of the diagnostic test including a test of goodness of fit, multi-collinearity test, and minimum criteria of the model utilization with the classification accuracy of 55%. The variables like family monthly income (OR=1.000011, C.I=1.000001 - 1.000020), students’ daily pocket money (OR=1.02, C.I=1.007 - 1.033), gender (OR=0.354, C.I= 0.179 - 0.7), knowledge regarding junk food consumption (OR=2.744, C.I=1.366 - 5.511), attitude towards food choice (OR=2.487, C.I=1.288 – 4.803), friend’s encouragement for junk food consumption (OR=0.178, C.I=0.045 – 0.701), and occupation of father (business) (OR=2.867, C.I=1.084 – 7.581) are seen to be significant to the model High versus Low consumption. Students’ daily pocket money (OR=1.012, C.I=1.002 – 1.023), knowledge regarding junk food consumption (OR=2.427, C.I=1.293 – 4.553), restrictive food parenting practice (OR=2.228, C.I=0.945 – 5.253), friend’s encouragement for junk food consumption (OR=0.252, C.I=0.067 – 0.944), recognition of marketing promotion strategy (OR=0.523, C.I=0.295 – 0.928), educational level of mother (lower secondary level) (OR=5.465, C.I=1.069 – 27.952), occupation of father (business) (OR=2.47, C.I=1.056 – 5.777) are seen to be significant to the model Moderate versus Low consumption. Conclusion: Study revealed that more than one-fourth of the sampled students were high consumers of junk foods. Many factors are associated with the consumption of junk foods. Thus, addressing the issue of increasing consumption, developing strategies & conducting different research in this field is the must. Concerned authorities should also pay special attention to this subject matter.

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Extensive use of monosodium glutamate: a threat to public health?

Cited by 40 publications

References 19 publications

Therapeutic role of adipose tissue–derived stem cells versus microvesicles in a rat model of cerebellar injury

Therapeutic role of adipose tissue–derived stem cells versus microvesicles in a rat model of cerebellar injury

Sitagliptin Attenuates the Cognitive Deficits in L‐Methionine‐Induced Vascular Dementia in Rats

Multinomial Logistic Regression Model for Assessing Factors Associated with Junk Food Consumption of Secondary Level Students

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