Extensive vulval intraepithelial neoplasia treated with a new regime of systemic photodynamic therapy using <i>meta</i>‐tetrahydroxychlorin (Foscan®)

Campbell, S.; Curnow, Alison

doi:10.1111/j.1468-3083.2007.02365.x

Cited by 10 publications

(3 citation statements)

References 2 publications

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“…However, good cosmetic healing and preservation of function was reported overall. A case study of vulval intraepithelial neoplasia III (severe atypia) with a lowered drug dose (0.05 mg kg −1 ) gave excellent results in a case study (414). For a recent review on PDT of human papillomavirus‐related genital dysplasias see Soergel and Hillemanns (415).…”

Section: Clinical Experiencementioning

confidence: 99%

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Temoporfin (Foscan^®, 5,10,15,20‐Tetra(m‐hydroxyphenyl)chlorin)—A Second‐generation Photosensitizer^†,‡

Senge

Brandt

2011

Photochem & Photobiology

289

218

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Section: Clinical Experiencementioning

confidence: 99%

“…Naturally many other potential applications exist. These include the treatment of brain (309,416,414), prostate (9,310), pancreas (311) and others.…”

Section: Other Clinical Usesmentioning

confidence: 99%

Temoporfin (Foscan^®, 5,10,15,20‐Tetra(m‐hydroxyphenyl)chlorin)—A Second‐generation Photosensitizer^†,‡

Senge

Brandt

2011

Photochem & Photobiology

289

218

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“…Topical photodynamic therapy (PDT) offers an effective and non-invasive treatment with good cosmetic outcome for intraepithelial neoplasia and inflammatory dermatosis, such as psoriasis and viral warts. [2][3][4] PDT with 10-20% Methyl aminolaevulinate (MAL) has been reported in successfully treating periungual warts and superficial squamous cell carcinoma (SCC), and has been approved in treating actinic keratosis (AK) and Bowen's disease (BD) that are intraepithelial SCC. [5][6][7] These disorders and PEH share similar histological features, namely epidermal hyperplasia.…”

mentioning

confidence: 99%

Pseudoepitheliomatous Hyperplasia Treated by Photodynamic Therapy with Variable Irradiation Dose and Concentration of Photosensitizer

Jiao²,

Long³

2011

Photomedicine and Laser Surgery

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Objective: The aim of this study was to test the effectiveness of photodynamic therapy (PDT) in treating pseudoepitheliomatous hyperplasia (PEH) after skin wounding. Background Data: PEH is a difficult-to-treat extreme-degree acanthosis characterized by proliferation of the epithelium. Topical PDT offers an effective and non-invasive treatment for intraepithelial neoplasia and inflammatory dermatosis. These disorders and PEH show the same histological features: epidermal hyperplasia. To our knowledge, there have been no clinical trials published about therapeutic responses of PDT for PEH. Materials and Methods: After application of 10-30% methyl aminolaevulinate (MAL) emulsion, each lesion was irradiated with 633-nm red light at a total dose of 113-339 J/ cm 2 . Therapeutic response was assessed by clinical examination at 3 months. Results: Only 4 of 16 lesions clinically showed a minimal response. No response was observed in 12 of the 16 lesions, either with different cumulative doses or different concentrations of MAL. Conclusion: PEH after skin wounding responds poorly to the topical MAL-PDT. Besides removal of underlying diseases, surgical excision is still the recommended first option.

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Neoplasms of the Vulva and Vagina

Dewdney

Rotmensch

2017

Holland‐Frei Cancer Medicine

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Overview Vulvar and vaginal carcinomas are uncommon diseases that generally affect post‐menopausal women, although 19% of vulvar carcinomas occur in women >50 years old. Risk factors for vulvar cancer include human papilloma virus and chronic inflammation. Vulvar intraepithelial neoplasia can often be managed with wide local excision, but several other modalities have been utilized. Most vulvar malignancies are squamous cell carcinomas that are managed by surgical excision and radiotherapy. Sentinel lymph node biopsy has been used to spare the morbidity observed after regional lymph node dissection. For more advanced lesions, chemo‐radiotherapy with agents such as 5‐FU, cisplatin, and mitomycin C is utilized. Other vulvar malignancies include Bartholin gland carcinomas, basal cell carcinomas, verrucous carcinomas, and melanomas. Carcinomas of the vagina are most frequently squamous cell, but clear cell adenocarcinomas have been seen in younger women. In the past, clear cell carcinomas were associated with prenatal exposure to diethyl‐stibestrol. Vaginal melanomas can occur, as well as endodermal sinus tumors, rhrabdomysarcomas, and fibroepithelial vagina polyps.

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Extensive vulval intraepithelial neoplasia treated with a new regime of systemic photodynamic therapy using meta‐tetrahydroxychlorin (Foscan®)

Cited by 10 publications

References 2 publications

Temoporfin (Foscan^®, 5,10,15,20‐Tetra(m‐hydroxyphenyl)chlorin)—A Second‐generation Photosensitizer^†,‡

Temoporfin (Foscan^®, 5,10,15,20‐Tetra(m‐hydroxyphenyl)chlorin)—A Second‐generation Photosensitizer^†,‡

Pseudoepitheliomatous Hyperplasia Treated by Photodynamic Therapy with Variable Irradiation Dose and Concentration of Photosensitizer

Neoplasms of the Vulva and Vagina

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Extensive vulval intraepithelial neoplasia treated with a new regime of systemic photodynamic therapy using meta‐tetrahydroxychlorin (Foscan®)

Cited by 10 publications

References 2 publications

Temoporfin (Foscan®, 5,10,15,20‐Tetra(m‐hydroxyphenyl)chlorin)—A Second‐generation Photosensitizer†,‡

Temoporfin (Foscan®, 5,10,15,20‐Tetra(m‐hydroxyphenyl)chlorin)—A Second‐generation Photosensitizer†,‡

Pseudoepitheliomatous Hyperplasia Treated by Photodynamic Therapy with Variable Irradiation Dose and Concentration of Photosensitizer

Neoplasms of the Vulva and Vagina

Contact Info

Product

Resources

About

Temoporfin (Foscan^®, 5,10,15,20‐Tetra(m‐hydroxyphenyl)chlorin)—A Second‐generation Photosensitizer^†,‡

Temoporfin (Foscan^®, 5,10,15,20‐Tetra(m‐hydroxyphenyl)chlorin)—A Second‐generation Photosensitizer^†,‡