2021
DOI: 10.1101/2021.12.17.473198
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Extent of Molecular Chaperone Association Might Determine Fates of Membraneless Organelles during Aging in C. elegans

Abstract: Proteome imbalance can lead to protein misfolding and aggregation which is associated with pathologies. Protein aggregation can also be an active, organized process and can be exploited by cells as a survival strategy. In adverse conditions, it is beneficial to deposit the proteins in a condensate rather degrading and resynthesizing. Membrane less organelles (MLOs) are biological condensates formed through liquid liquid phase separation (LLPS), involving cellular components such as nucleic acids and proteins. … Show more

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