Extent, patterns, and burden of uncontrolled disease in severe or difficult‐to‐treat asthma

Sullivan, Sean D.; Rasouliyan, Lawrence; Russo, Patrícia A.; Kamath, Tripthi; Chipps, Bradley E.

doi:10.1111/j.1398-9995.2006.01254.x

Cited by 168 publications

(114 citation statements)

References 27 publications

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“…Also, a higher ATAQ score (more control problems) was associated with lower quality of life in subjects with asthma, indicated by generic and diseasespecific quality of life measures, such as the SF-36, the standardized version of the Asthma Quality of Life Questionnaire, 12 and the Mini Asthma Quality of Life Questionnaire. 55,68 Furthermore, a strong correlation and similar performance were reported between the ATAQ and the ACT at home and in clinical settings (r ϭ Ϫ0.73). 25,69,70 …”

Section: Validitysupporting

confidence: 59%

“…Sullivan et al 68 reported that the costs for uncontrolled asthma, as indicated by the ATAQ score, were more than double those with scores indicating controlled asthma. Also, a higher ATAQ score (more control problems) was associated with lower quality of life in subjects with asthma, indicated by generic and diseasespecific quality of life measures, such as the SF-36, the standardized version of the Asthma Quality of Life Questionnaire, 12 and the Mini Asthma Quality of Life Questionnaire.…”

Section: Validitymentioning

confidence: 99%

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Asthma Control Assessment Tools

Alzahrani

Becker

2015

Respir Care

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, and they emphasize periodic assessment of asthma control once treatment is established. Accurate assessment of asthma control is difficult due to the complexity of asthma control and due to the limitations in the traditional methods of assessment, such as lung function tests, physician assessment, and patients' self-assessment. Relying solely on the role of lung function tests is insufficient to reflect the status of asthma control, since patients with asthma may have normal spirometry between exacerbations. Clinicians often overestimate the level of asthma control. Similarly, it is not uncommon for patients to overestimate how well their asthma is controlled, and, therefore, they under-report asthma symptoms and fail to recognize the impact that asthma has on their daily life. As a result, several tools have been developed to quantify the level of asthma control, identify patients at risk, and evaluate the effect of asthma management. This review examines the commonly 106RESPIRATORY CARE • JANUARY 2016 VOL 61 NO 1 used asthma control assessment tools in terms of content, psychometric properties, methods of administration, limitations, and ability to reflect the overall status of asthma control, which can aid clinicians in selecting the most appropriate tool for their needs.

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Section: Validitysupporting

confidence: 59%

Section: Validitymentioning

confidence: 99%

Asthma Control Assessment Tools

Alzahrani

Becker

2015

Respir Care

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“…As a consequence of the above-mentioned differences, determinants and clinical correlates of control and severity may not be identical: for instance, body mass index and obesity are associated with control and quality of life but not with severity (13,14); conversely, tobacco smoking is associated with both poorer control and increased severity (15,16), although this relationship was not significant in the study by Sullivan et al (2). In addition, for patients with a N. Roche 1 , P. Godard given level of severity, control is an additional contributor to quality of life (17).…”

contrasting

confidence: 44%

“…Data presented by Sullivan et al in this issue of Allergy show that patients with severe asthma are frequently uncontrolled, which increases direct and indirect costs of the disease (2). Such results are not really surprising, but they are strengthened by the large scale of the study, which allows quantifying differences more reliably.…”

Section: Control Of Asthma: What Is the Target?mentioning

confidence: 54%

Control and severity: complementary approaches to asthma management

Roche

Godard

2007

Allergy

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“…School aged children had a higher risk of INS, as allergic asthma is more prevalent in school-aged children, the higher prevalence of INS seen in this age group was therefore consistent with an association between INS and allergic asthma. In addition, we also found children with more asthma-related visits per year had greater risk of INS, which may reflect the association between INS risk and uncontrolled airway inflammation, more severe and persistent phenotype of asthma or more environmental triggers, such as allergen exposure or respiratory virus in asthma children (25,26). Moreover, greater risk of INS was observed within the first 5.5 y after asthma diagnosis.…”

mentioning

confidence: 69%

Risk of idiopathic nephrotic syndrome among children with asthma: a nationwide, population-based cohort study

et al. 2015

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Background:Although clinical and immunological studies have shown a possible link between allergy and idiopathic nephrotic syndrome (INS), the nature of the relationship remains unclear. Asthma is the most common chronic allergic airway inflammation. However, no study has used a longitudinal design with a population cohort to investigate INS in children with asthma. Methods: Using nationwide claims data from 2000 through 2007, we randomly selected 251,698 asthma cases and 1,006,791 frequency-matched controls. Incidence rates of INS and hazard ratios (HRs) were calculated. results: The INS incidence was 3.36-fold greater in the asthma cohort than in the nonasthma control (9.26 vs. 2.76 per 100,000 person-years; 95% confidence interval (CI): 2.65-4.26). The HR for INS increased for those with more asthma-related medical visits per year, from 1.49 (95% CI: 1.06-2.11) for <3 visits to 15.7 (95% CI: 11.5-21.5) for ≥6 visits (trend test, P < 0.0001). The HR for INS slightly decreased during the follow-up period, from 3.41 (95% CI: 2.66-4.38) for ≤5.5 y to 2.90 (95% CI: 1.33-6.30) for >5.5 y. conclusion: We conclude that children with asthma had an increased incidence rate of INS, and increased incidence rate correlated with asthma-related medical visits.i diopathic nephrotic syndrome (INS) is among the most common chronic kidney diseases occurring in childhood (1). Numerous studies have associated INS with allergy risk of clinical and immunological features (2-11). In the 1950s through the 1970s, few anecdotal reports described patients who developed INS after allergic reactions to inhaled allergens, vaccinations, food, or insect stings (2-5). Since 1970, several case-control studies revealed that elevated serum IgE and atopic diathesis were more common in children with INS than non-INS controls (9,(11)(12)(13)(14)(15)(16)(17). Recently, levels of T helper 2 (Th2)-associated cytokine such as interleukin (IL)-4 and IL-13 were found to be elevated in relapsing INS patients (18-21). Children with INS commonly have elevated serum levels of immunoglobulin E (IgE), which also plays a central role in allergic inflammation (11)(12)(13)(14)(15)(16). Although clinical and immunological studies have shown a possible link between allergic diseases and INS for 50 y, human epidemiologic study using a large cohort to investigate the relationship between these disorders are lacking (2-11). Asthma is one of the most common allergic disease in childhood, affects a multitude of patients worldwide (22). It is unknown whether childhood onset asthma would increase the subsequent risk of INS. Therefore, we conducted a nationwide, population-based cohort study to examine the hypothesis that asthma may have positive influence on the development of INS in children. RESULTSA total of 251,698 subjects in the asthma cohort and 1,006,791 in the nonasthma cohort were enrolled in this study (Table 1). Most (67.6%) of the subjects were aged ≤5 y. The asthma cohort had more boys (59.4%), residents of highly urbanized areas (59.8%), and white-collar pa...

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Extent, patterns, and burden of uncontrolled disease in severe or difficult‐to‐treat asthma

Abstract: This study demonstrated that few severe or difficult-to-treat asthma patients achieved control over a 2-year period and the economic consequence of uncontrolled disease is substantial.

Cited by 168 publications

References 27 publications

Asthma Control Assessment Tools

Asthma Control Assessment Tools

Control and severity: complementary approaches to asthma management

Risk of idiopathic nephrotic syndrome among children with asthma: a nationwide, population-based cohort study

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