External irradiation for squamous cell carcinoma of the nasal vestibule

Wong, Christine; Elhakim, T; Briant, T. D. R.

doi:10.1016/0360-3016(86)90129-x

Cited by 40 publications

(30 citation statements)

References 11 publications

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“…Men are affected approximately 3 times as frequently as women (15,25,29). However, in 2 recent series from Rotterdam, there was only one woman in 69 cases reported (1, 13).…”

Section: Pathologymentioning

confidence: 98%

“…The size and local extent of the primary carcinoma are major prognostic indicators for local control and survival. Wong et al (29) showed significantly better local relapse-free rates and survival for lesions measuring less than 2 cm, and Mak et al (13) found longer recurrence-free intervals for cancers measuring less that 1.5 cm. Wang reported an 89% 3-year disease-free rate for lesions limited to the nasal vestibule, and the corresponding figure for more extensive lesions was only 64% (26).…”

Section: Pathologymentioning

confidence: 99%

“…The incidence of lymph node metastases diagnosed at presentation is less than 10% (Table l), and are more common with large cancers and with those involving bone and cartilage. Although submandibular nodes are involved most commonly (15,29), Wang (25) reported subdigastric involvement in all 5 patients who presented with clinical nodal metastases. There is only one reported case of distant metastasis (lung) at presentation (13).…”

Section: Pathologymentioning

confidence: 99%

“…Approximately half of the patients present with disease confined to the nasal vestibule (26,29). Involvement of alar and septal cartilage is common, and may cause septal perforation or, less commonly, penetration through the dar cartilage into the skin.…”

Section: Pathologymentioning

confidence: 99%

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The Place of Radiation Therapy in the Treatment of Squamous Cell Carcinoma of the Nasal Vestibule

Wong

1988

Acta Oncologica

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“…Men are affected approximately 3 times as frequently as women (15,25,29). However, in 2 recent series from Rotterdam, there was only one woman in 69 cases reported (1, 13).…”

Section: Pathologymentioning

confidence: 98%

Section: Pathologymentioning

confidence: 99%

Section: Pathologymentioning

confidence: 99%

Section: Pathologymentioning

confidence: 99%

See 2 more Smart Citations

The Place of Radiation Therapy in the Treatment of Squamous Cell Carcinoma of the Nasal Vestibule

Wong

1988

Acta Oncologica

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“…Human papillomavirus infection and smoking are considered to be risk factors (12). However, their prognosis remains better compared with that of other sinonasal malignant tumors, such as maxillary sinus and frontal sinus malignant tumor (13,14). The 5-year recurrence-free survival rates range widely between 20 and 92% (15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Synchronous double primary cancer of the lung and nasal vestibule: A case report and literature review

Zang

Wang

et al. 2016

Molecular and Clinical Oncology

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Abstract. Squamous cell carcinoma (SCC) of the nasal vestibule is a rare tumor entity, and its occurrence combined with lung cancer is even rarer. Thus, several patients are often initially misdiagnosed or remain undiagnosed. This is the case report of a 55-year-old male patient who presented to our hospital with a neoplasm in the left lung. The patient was treated with left upper pulmonary lobectomy and the subsequent histopathological examination of the surgical specimen revealed a poorly differentiated SCC. On postoperative week 4, the patient presented with purulent and bloody discharge from the left nostril and was misdiagnosed with an upper jaw cyst. After another 3 weeks, the patient was re-admitted to the hospital with a mass of left nostril and nasal congestion. Tru-Cut biopsies from the nasal area and histopathological examination revealed a moderately differentiated SCC. According to the clinical presentation and the histopathological findings, the patient was diagnosed with double primary cancer of the lung and the nasal vestibule. The mass of the left nostril was significantly reduced in size with radiotherapy. To the best of our knowledge, there is no similar case previously reported in the literature. Due to the rarity of SCC of the nasal vestibule concomittant with lung cancer, we herein present this case report with a review of the relevant literature and investigation of the clinical characteristics. IntroductionMultiple primary cancers are defined as ≥2 separate original cancers, simultaneously or successively occurring in the same or different organs. Double primary cancer is the most common type of multiple primary cancer and it is classified as synchronous carcinoma (SC) and metachronous carcinoma (MC). SC is used to describe the second primary tumor when it is diagnosed simultaneously or within 6 months of the diagnosis of the first primary tumor. MC is is used to describe the second cancer when it is diagnosed >6 months after the first primary cancer (1). The first double primary cancer was reported in 1889 by Billroth (2), whose standard of the diagnosis was that each tumor should have a different localization and independent histological appearance. In 1932, Warren and Gates established new criteria, which are still applied today: i) Both cancers must be definitively malignant according to the histopathological examination; ii) the cancers must be histologically different; and iii) it must be established that the second cancer is not a metastatic lesion of the first (3). The incidence of multiple primary cancers appears to have increased significantly. Approximately 10% of cancer patients develop another primary cancer within 10 years of the first surgery (4). However, double primary cancer of the lung and nasal vestibule is uncommon. We herein describe an extremely rare case of synchronous double primary cancer involving the left nasal vestibule and the left lung, with a review of the literature. Case reportA 55-year-old man presented to the Qianfoshan Hospital on April 8, 2015, where ...

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Regional Recurrence of Squamous Cell Carcinoma of the Nasal Cavity

Scurry

Goldenberg²,

Chee

et al. 2007

Arch Otolaryngol Head Neck Surg

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To demonstrate whether the regional recurrence (RR) of squamous cell carcinoma (SCC) of the nasal cavity is higher than previously suspected. Data Sources: Original articles, including a previously published series from our institution, were identified from systematic searches of the MEDLINE database. Study Selection: Studies that analyzed tumors other than SCC or tumors from sites other than the nasal cavity were excluded. Studies that did not report an RR were also excluded. Data Extraction: Studies identified by the literature search were reviewed by a single reviewer (W.C.S.), and studies not excluded were reviewed for data extraction by 2 reviewers (W.C.S. and M.Y.C.). Data Synthesis: From the 23 studies reviewed, the average weighted percentage RR for SCC of the nasal cavity was 18.1% (95% confidence interval, 13.4%-22.8%). Conclusions: Currently, few authors advocate elective treatment of the neck in patients with high-risk SCC of the nasal cavity. The results of this systematic review and meta-analysis demonstrate that the RR of this entity may be higher than previously suspected. Because many studies included other histopathologies or analyzed recurrence data from tumors of multiple subsites, a true RR for SCC of the nasal cavity has not been firmly established. Now that a uniform staging system exists for nasal cavity cancers, better prospective analysis of these tumors will be available. The authors suggest that the risk of RR of certain high-risk SCCs of the nasal cavity to the lymph nodes, including the perifacial and upper cervical lymphatics, may approach the frequently cited 20% risk suggestive of consideration for elective regional therapy.

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External irradiation for squamous cell carcinoma of the nasal vestibule

Cited by 40 publications

References 11 publications

The Place of Radiation Therapy in the Treatment of Squamous Cell Carcinoma of the Nasal Vestibule

The Place of Radiation Therapy in the Treatment of Squamous Cell Carcinoma of the Nasal Vestibule

Synchronous double primary cancer of the lung and nasal vestibule: A case report and literature review

Regional Recurrence of Squamous Cell Carcinoma of the Nasal Cavity

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