External Quality Assurance in Cervical/Vaginal Cytology

Cocchi, Valeria; Sintoni, Catia; Carretti, D; Sama, Donatella; Chiari, U.; Segala, Valentina; Delazer, Anna Lucia; Grilli, N.; Papaleo, R; Ghirardini, Carla; Bucchi, Lauro

doi:10.1159/000333903

Cited by 20 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of disagreeing cases is related to obscuring factors that partially affect the analysis of the smear. Our results were consistent with those of Cocchi et al [28], who found a low interlaboratory agreement concerning the adequacy of the sample that showed kappa variation between 0.01 and 0.29 and epithelial abnormalities ranging between 0.53 and 0.78.…”

Section: Discussionsupporting

confidence: 93%

External Quality Control of Cervical Cytopathology: Interlaboratory Variability

Ázara¹,

Manrique²,

Souza³

et al. 2013

Acta Cytologica

View full text Add to dashboard Cite

Objective: To compare the variability of screening tests held at laboratories with the Unit for External Quality Control (UEQC), checking the frequency of cases that were discordant, false-positive, false-negative, unsatisfactory or that had a delay in clinical management and diagnostic agreement. Materials and Methods: The study analyzed 10,053 screening tests from January 2007 to December 2008, including all positive cases, all those that fall under unsatisfactory and at least 10% of negative screening tests. The magnitude of the agreement was analyzed using the kappa coefficient. Results: Out of the 10,053 cases analyzed, 7.59% were considered disagreeing, and it was estimated that 1.1% were false-negative. There was a delay in the clinical procedure regarding 2.44% cases. There were 2.82% of cases identified as false-positive and 1.24% as unsatisfactory. The diagnostic agreement was excellent (kappa = 0.81). The agreement of most laboratories concerning screening tests was classified as very good. The agreement of the sample adequacy was reasonable (kappa = 0.30) and the agreement regarding the representation of epithelia was considered excellent. Conclusion: Most laboratories showed very good agreement; however, it is worthy of note that to establish the standardization of diagnostic criteria, and enhance the accuracy of screening and improve the quality of cytopathology test results, it is necessary to perform external quality control.

show abstract

Section: Discussionsupporting

confidence: 93%

External Quality Control of Cervical Cytopathology: Interlaboratory Variability

Ázara¹,

Manrique²,

Souza³

et al. 2013

Acta Cytologica

View full text Add to dashboard Cite

show abstract

“…obtained by a group of specialists (COCCHI et al, 1996;KATO et al, 1995) . In this work we used a review interpretation accomplished by detailed consensual analysis and discussion of an entire set of smears by two cytologists based on well-established morphological criteria.…”

Section: Resultsmentioning

confidence: 99%

Interobserver Variability of Cervical Smears by Rescreening in Small Laboratories of Paraná and Santa Catarina, Brazil

Lima¹,

Plewka²,

Basso³

et al. 2009

Rev. Eletr. Farm.

View full text Add to dashboard Cite

A neoplasia cervical constitui um problema de saúde pública em âmbito mundial, estimando-se que seja a terceira mais comum na população feminina. Na realização do exame de Papanicolaou, principal instrumento para a detecção de anormalidades epiteliais, deve-se buscar formas de reduzir as variações, através do aprofundamento e uniformização de critérios morfológicos e da constante revisão de lâminas. Este trabalho visou estudar a variação interobservadores na avaliação citológica de material cervical para a interpretação de lesões pré-neoplásicas e neoplásicas, com a participação de citologistas de laboratórios de pequeno porte nos Estados do Paraná e Santa Catarina. Para tanto, foram avaliados 46 esfregaços de citologia cérvico-vaginal por 4 observadores, em estudo cego, de acordo com seus procedimentos rotineiros. Os resultados foram comparados com um consenso obtido por 2 citologistas experimentados, de acordo com os critérios morfológicos preconizados pelo Sistema Bethesda 2001 para citologia cérvico-vaginal. Um número maior de lâminas foi observado para as classificações NILM, LSIL e HSIL. As percentagens globais de concordância foram NILM, 93,7%; ASC, 15,0%; LSIL, 32,5%, e HSIL, 50,0%. Em todos os pares, as correlações para os resultados dos citologistas foram estatisticamente significativas (p < 0,05).

show abstract

Intralaboratory quality assurance in cervical/vaginal cytology: Evaluation of intercytologist diagnostic reproducibility

et al. 1997

Self Cite

View full text Add to dashboard Cite

Diagnostic reproducibility and accuracy in evaluating cervical/vaginal smears were the focus of this study concerning intralaboratory quality control. A set of 120 cytological samples was evaluated by 15 cytopathologists whose experience ranged from 3–29 yr. The study report form was based on the 1988 Bethesda System. Intercytologist reproducibility (with respect to sample adequacy, epithelial cell abnormalities, and presence of cellular changes associated with HPV, Human Papilloma virus) was evaluated using the Kappa statistic. Poor reproducibility in defining sample adequacy was observed (K = 0.24). The agreement on epithelial cell abnormality definition was good (K = 0.64); the lowest reproducibility was observed for High‐grade squamous intraepithelial lesion/cervical intraepithelial neoplasia HSIL/CIN II (specific K = 0.37) and Atypical cells of undetermined significance ACUS (specific K − 0.44). The agreement in detecting cellular changes associated with HPV was fair (K = 0.49). Diagnostic accuracy for epithelial cell abnormalities, assessed by comparison with a consensus reference diagnosis, was good (K = 0.74). Diagn. Cytopathol. 16:87–92, 1997. © 1997 Wiley‐Liss, Inc.

show abstract

External Quality Assurance in Cervical/Vaginal Cytology

Cited by 20 publications

References 5 publications

External Quality Control of Cervical Cytopathology: Interlaboratory Variability

External Quality Control of Cervical Cytopathology: Interlaboratory Variability

Interobserver Variability of Cervical Smears by Rescreening in Small Laboratories of Paraná and Santa Catarina, Brazil

Intralaboratory quality assurance in cervical/vaginal cytology: Evaluation of intercytologist diagnostic reproducibility

Contact Info

Product

Resources

About