External stimuli-responsive drug delivery systems

Vinchhi, Preksha; Rawal, Shruti; Patel, Mayur M.

doi:10.1016/b978-0-12-819838-4.00023-7

Cited by 15 publications

(11 citation statements)

References 85 publications

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“…Protein‐based materials like albumin, collagen, and gelatin can be degraded by enzymes including collagenases, lysozyme, proteinase, and peptidase. [ 104 ] The in vitro degradability of HSAMA 4 hydrogels was investigated in 1 mg mL −1 proteinase K at 37 °C with 150 rpm shaking. HSAMA 4 hydrogels showed biodegradable behavior after being immersed in proteinase K for some time.…”

Section: Resultsmentioning

confidence: 99%

Human Albumin‐Based Hydrogels for Their Potential Xeno‐Free Microneedle Applications

Rong

Mehwish

Niu

et al. 2023

Macromolecular Bioscience

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Nowadays, hydrogels-based microneedles (MNs) have attracted a great interest owing to their outstanding qualities for biomedical applications. For the fabrication of hydrogels-based microneedles as tissue engineering scaffolds and drug delivery carriers, various biomaterials have been tested. They are required to feature tunable physiochemical properties, biodegradability, biocompatibility, nonimmunogenicity, high drug loading capacity, and sustained drug release. Among biomaterials, human proteins are the most ideal biomaterials for fabrication of hydrogels-based MNs; however, they are mechanically weak and poorly processible. To the best of the knowledge, there are no reports of xeno-free human protein-based MNs so far. Here, human albumin-based hydrogels and microneedles for tissue engineering and drug delivery by using relatively new processible human serum albumin methacryloyl (HSAMA) are engineered. The resultant HSAMA hydrogels display tunable mechanical properties, biodegradability, and good biocompatibility. Moreover, the xeno-free HSAMA microneedles display a sustained drug release profile and significant mechanical strength to penetrate the model skin. In vitro, they also show good biocompatibility and anticancer efficacy. Sustainable processible human albumin-based biomaterials may be employed as a xeno-free platform in vivo for tissue engineering and drug delivery in clinical trials in the future.

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Section: Resultsmentioning

confidence: 99%

Human Albumin‐Based Hydrogels for Their Potential Xeno‐Free Microneedle Applications

Rong

Mehwish

Niu

et al. 2023

Macromolecular Bioscience

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“…Hydrogel purification via solvent washing or dialysis should be performed to ensure removal of unreacted species. 111 In some cases, it is desirable to generate DN hydrogels at the biological site, such as upon injection, and purification post gelation is not possible. 112 Furthermore, the use of ionic crosslinking interactions, which are prevalent in the preparation of alginate and chitosan-based DN hydrogels, can present issues regarding long-term stability for these materials.…”

Section: Discussionmentioning

confidence: 99%

Recent advances in double network hydrogels based on naturally-derived polymers: synthesis, properties, and biological applications

Sinad,

Ebubechukwu,

Chu

2023

J. Mater. Chem. B

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“…Alginate is a common example of an ionic cross‐linked hydrogel when it is mixed with divalent cations. [ 46 ] On the other hand, complex coacervation is the rapid aggregation of two polyelectrolytes with opposing charges, resulting in a liquid–liquid phase separation in an aqueous medium. [ 47 ] Some examples of this type of physical hydrogels are those made by coacervating chitosan and xanthan.…”

Section: Matrices Crf: Definition and Loading Techniquesmentioning

confidence: 99%

Advances in Controlled Release Fertilizers: Cost‐Effective Coating Techniques and Smart Stimuli‐Responsive Hydrogels

Mansouri

Said

Noukrati

et al. 2023

Advanced Sustainable Systems

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To meet the needs of a rapidly expanding global population, farmers will need more fertilizers than ever before to maintain a steady supply of affordable, nutritious food. The formulation of controlled release fertilizers (CRF) to synchronize nutrient release according to the demand of plants has emerged as a viable solution to the current problems associated with the poor nutrient usage efficiency of fertilizers. Yet, the greatest obstacle that still stands in the way of broad use of CRF in agriculture is their expensive manufacturing costs. The first section of this analysis focuses on broad topics related to CRF. Afterward, the differences between several cost‐effective raw materials and some of the production techniques used to make CRF are examined. Furthermore, the emerging field of “smart” coating materials, such as stimuli‐responsive coatings, which can accurately tailor nutrients delivery to the demands of the vegetation, is discussed, and the most important research work that could lead to their extensive use in agriculture is pointed out. The purpose of this review is to provide a strong assessment of CRF's development over the past several years by highlighting innovations and providing in‐depth analysis of prevailing patterns to better understand the future of agriculture.

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External stimuli-responsive drug delivery systems

Cited by 15 publications

References 85 publications

Human Albumin‐Based Hydrogels for Their Potential Xeno‐Free Microneedle Applications

Human Albumin‐Based Hydrogels for Their Potential Xeno‐Free Microneedle Applications

Recent advances in double network hydrogels based on naturally-derived polymers: synthesis, properties, and biological applications

Advances in Controlled Release Fertilizers: Cost‐Effective Coating Techniques and Smart Stimuli‐Responsive Hydrogels

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