External validation and updating of prediction models for estimating the 1-year risk of low health-related quality of life in colorectal cancer survivors

Quality of life of colorectal cancer survivors: Mapping the key indicators by expert consensus and measures for their assessment

“…With the growing population of colorectal cancer survivors [8], the focus in their clinical care and support is shifting towards the recognition of the importance of their QoL [16,17] consequently raising a need for regular assessments and monitoring of QoL that are necessary to detect areas that might need to be addressed for each individual patient. Even though several barriers to the implementation of such assessments in the clinical routine persist [27], identifying the QoL domains that are of importance not only the survivors, but also to their HCPs, along with providing the appropriate questionnaires that address those domains, is critical to assist this process.…”

“…One of the most burdensome cancers is colorectal cancer, being the second leading cause of cancer-related death [1] and the third most common cancer in males and females [1,5] representing 10.7 % of new cases in 2020 [2] with its incidence still expected to grow [6]. With the current five-year survival rates in most developed countries ranging from 50 % to over 70 % [4,6,7] and increasing, the population of colorectal cancer survivors is also growing [8].…”

“…A recent meta-analysis [5] found that colorectal cancer survivors have a 51 % increased risk of experiencing depression after diagnosis and do experience high levels of anxiety and depression regarding health related QoL and mortality. Even though the major deterioration of health related QoL occurs during the first six months after diagnosis and treatment [8], many cancer survivors still report on negatively impacted QoL well into survivorship period [8,15]. Improving QoL of colorectal cancer survivors is important, not only from the survivors' perspective to be provided with appropriate and tailored care, but also as the growing population of survivors is posing an increasing burden on health-care systems due to their persistent health problems and decreased levels of QoL [8,15].…”

“…Even though the major deterioration of health related QoL occurs during the first six months after diagnosis and treatment [8], many cancer survivors still report on negatively impacted QoL well into survivorship period [8,15]. Improving QoL of colorectal cancer survivors is important, not only from the survivors' perspective to be provided with appropriate and tailored care, but also as the growing population of survivors is posing an increasing burden on health-care systems due to their persistent health problems and decreased levels of QoL [8,15]. This need is also reflected in the actions promoted by the European Commission, such as Mission Cancer recognizing the QoL as one of the most important areas of intervention [16], and EU Beating Cancer Plan urging to change focus from the length of life after diagnosis, to length and QoL after diagnosis [17].…”

Prediction of postoperative health-related quality of life among patients with metastatic spinal cord compression secondary to lung cancer

“…Therefore, recognizing the potential impact of the above factors on patient well-being is crucial in understanding the context in which the study was conducted and the generalizability of the findings to other settings or time periods. According to previous studies, there were models to predict quality-of-life outcomes among patients with pancreatic cancer (28), cervical cancer survivors (29), colorectal cancer survivors (30,31), patients who underwent colorectal cancer surgery (32), and patients who underwent prostate radiation therapy (33)…”