External validation of Chronic Pancreatitis Prognosis Score (COPPS): A prospective cohort study

Maheshwari, Ankit; Patra, Partha Sarathi; Ray, Sukanta; Dhali, G. K.; Das, Kshaunish

doi:10.1016/j.dld.2021.08.022

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…This could explain why malnutrition was more common in patients diagnosed within the last year. A higher COPPS has been shown to be associated with an increased risk of readmission and longer hospital stay ( 15 , 24 ). Because COPPS comprises multiple parameters related to nutritional status and inflammation, our data does not allow to determine whether it is the cause or the effect of malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function

et al. 2022

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Background/AimsPatients with chronic pancreatitis (CP) have an increased risk of malnutrition, a condition linked to reduced muscle mass and physical performance. We have investigated the risk factors, phenotypic presentation, and health implications associated with malnutrition in CP.Materials and MethodsIn a multicenter cross-sectional study we recruited patients with confirmed CP and healthy volunteers as a control group. Malnutrition was diagnosed according to the criteria proposed by the Global Leadership Initiative on Malnutrition. We performed detailed examinations of body composition and physical function as well as testing of routine blood parameters and markers of inflammation.ResultsWe included 66 patients [mean (±SD) age: 56.0 (±14.5) years; 51 males] and an equal number of age- and sex-matched controls. Moderate malnutrition was diagnosed in 21% (n = 14) and severe malnutrition in 42% (n = 28) of patients. Besides weight loss malnourished patients showed lower fat and skeletal muscle mass compared to both non-malnourished subjects and healthy controls. Only in severe malnutrition, blood parameters reflected elevated inflammation and reduced muscle reserves. Handgrip strength in patients did not differ by nutritional status but there was a significant correlation (rho = 0.705, p < 0.001) with skeletal muscle mass. Although 20 patients (30%) had pathologically reduced skeletal muscle mass, only two individuals (3%) had sarcopenia with concomitantly reduced handgrip strength.ConclusionMalnutrition is a frequent complication of CP characterized by loss of skeletal muscle mass. As this condition becomes evident only at an advanced stage, regular testing for altered body composition is recommended. Suitable biomarkers and the link between loss of muscle mass and physical function require further investigation.Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT04474743], identifier [NCT04474743].

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Section: Discussionmentioning

confidence: 99%

Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function

et al. 2022

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“…Patients especially in the COPPS B and C category experience significantly more inpatient treatment days within 12 months, underscoring the prognostic value of the score. COPPS as validated in a larger independent cohort, including patients from Germany and Denmark and another prospective validation study from India also detected a correlation between higher COPPS categories and the number and length of hospitalizations in this geographically divergent patient population of 171 patients [24]. An international multicentre, prospective COPPS validation study has finished recruitment, data being currently analysed, preliminary results validating previous findings and the ongoing ESGE endorsed ESCOPA trial initiated by the Dutch Pancreatitis Study Group is investigating a potential role of COPPS in predicting response to endoscopic therapy and as a surrogate for treatment success.…”

Section: Severity Classification and Prognosis By Using The Chronic P...mentioning

confidence: 69%

Clinical and translational markers of severity and prognosis in chronic pancreatitis

Sirtl

Beyer

Mayerle

2022

Current Opinion in Gastroenterology

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Purpose of reviewThe incidence of chronic pancreatitis as a progressive inflammation and fibrosis syndrome is on the rise due to increasing awareness and improved imaging modalities. Numerous classification systems have been suggested in recent years to describe the disease, but only few of them have been used to classify the severity and prognostic significance of the disease. Biomarkers for severity and (early) chronic pancreatitis diagnosis are not yet ready for clinical application.Recent findingsIn using the M-ANNHEIM and Chronic Pancreatitis Prognosis Score (COPPS) classification system, the severity assessment and short- and medium-term disease progression is available. A prospectively validated biomarker for early chronic pancreatitis diagnosis is not yet available, metabolome-based approaches seem to have the greatest potential for clinical translation.SummaryCurrently, due to the lack of universal definition for the early disease stage of chronic pancreatitis, it is difficult to accurately classify these patient cohorts in existing scoring systems. In principle, setting up a suitable scoring system would allow surveillance and establish a therapy approaches flanked by corresponding biomarker panel development. Therapy management of chronic pancreatitis and monitoring by means of scoring systems (such as the COPPS) would make a decisive contribution to improving patient treatment.

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“…Besides, the Chronic Pancreatitis Prognosis Score, a dynamic multi-variate scoring system similar to the Child-Pugh Score for liver cirrhosis, has been developed and validated for the evaluation of hospitalization and readmission risk of CP patients. 129 , 130 The results of this research will be of great importance to predict which patients with CP will benefit from different kinds of therapies.…”

Section: Evaluation and Prediction Of Treatment Responsementioning

confidence: 99%

Management of chronic pancreatitis: recent advances and future prospects

Han,

Lv,

2024

Therap Adv Gastroenterol

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As a progressive fibroinflammatory disease, chronic pancreatitis (CP) often manifests as recurrent bouts of abdominal pain with or without complications, causing a heavy burden of health care. In recent years, some meaningful insights into the management of CP have been obtained from randomized controlled trials, systematic reviews, and meta-analyses, which were of great importance. Based on this research, it is shown that there are various treatments for CP. Therefore, it is of great importance to choose a suitable strategy for patients with CP individually. Relevant evidence on the management of CP was summarized in this review, including nutrition supplements, medication, endoscopy, surgery, exploration of novel therapies as well as evaluation and prediction of treatment response.

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External validation of Chronic Pancreatitis Prognosis Score (COPPS): A prospective cohort study

Cited by 7 publications

References 19 publications

Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function

Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function

Clinical and translational markers of severity and prognosis in chronic pancreatitis

Management of chronic pancreatitis: recent advances and future prospects

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