External Validation of the H
            <sub>2</sub>
            F-PEF Model in Diagnosing Patients With Heart Failure and Preserved Ejection Fraction

Sepehrvand, Nariman; Alemayehu, Wendimagegn; Dyck, Garrison J B; Dyck, Jason R.B.; Anderson, Todd J.; Howlett, Jonathan G.; Paterson, Ian; McAlister, Finlay A.; Ezekowitz, Justin A.

doi:10.1161/circulationaha.118.038594

Cited by 54 publications

(53 citation statements)

References 5 publications

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“…These findings are in keeping with regional differences in event rates suggesting a four‐fold lower risk of the primary outcome in Russia/Georgia as compared with the Americas . When applied to a referral cohort from Alberta, Canada, the discriminatory value of the H 2 FPEF score was lower than that observed in the original derivation and internal validation cohorts . Taken together, these data emphasize the ongoing need to understand the variability in distribution and performance of the H 2 FPEF score across global, heterogeneous populations.…”

Section: Baseline Characteristics Of Patients In Topcat By Categoriessupporting

confidence: 67%

“…1 When applied to a referral cohort from Alberta, Canada, the discriminatory value of the H 2 FPEF score was lower than that observed in the original derivation and internal validation cohorts. 8 Taken together, these data emphasize the ongoing need to understand the variability in distribution and performance of the H 2 FPEF score across global, heterogeneous populations.…”

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confidence: 86%

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Application of the H₂FPEF score to a global clinical trial of patients with heart failure with preserved ejection fraction: the TOPCAT trial

Myhre

Vaduganathan

Claggett

et al. 2019

European J of Heart Fail

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Section: Baseline Characteristics Of Patients In Topcat By Categoriessupporting

confidence: 67%

mentioning

confidence: 86%

Application of the H₂FPEF score to a global clinical trial of patients with heart failure with preserved ejection fraction: the TOPCAT trial

Myhre

Vaduganathan

Claggett

et al. 2019

European J of Heart Fail

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“…This may reduce the clinical value of the H 2 FPEF score in a less selective population, but this is yet to be tested. Recently, the H 2 FPEF score has been extrapolated to the TOPCAT trial in two independent analyses and a Canadian HF cohort, observing that the score has a high sensitivity and specificity to diagnose HFpEF and can be a helpful tool to detect regional heterogeneity with, however, lower sensitivity in the Canadian cohort . The HFA‐PEFF score uses a more comprehensive stepwise approach including more known pathophysiologic markers for the presence of HFpEF.…”

Section: Discussionmentioning

confidence: 99%

Validation of the HFA‐PEFF score for the diagnosis of heart failure with preserved ejection fraction

Aizpurua

Wijk

Rocca

et al. 2019

European J of Heart Fail

125

128

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Aims Diagnosing heart failure with preserved ejection fraction (HFpEF) is challenging. The newly proposed HFA‐PEFF algorithm entails a stepwise approach. Step 1, typically performed in the ambulatory setting, establishes a pre‐test likelihood. The second step calculates a score based on echocardiography and natriuretic peptides. The aim of this study is to validate the diagnostic value and establish the clinical impact of the second step of the HFA‐PEFF score. Methods and results The second step of the HFA‐PEFF score was evaluated in two independent, prospective cohorts, i.e. the Maastricht cohort (228 HFpEF patients and 42 controls) and the Northwestern Chicago cohort (459 HFpEF patients). In Maastricht, the HFA‐PEFF score categorizes 11 (4%) of the total cohort with suspected HFpEF in the low‐likelihood (0–1 points) and 161 (60%) in the high‐likelihood category (5–6 points). A high HFA‐PEFF score can rule in HFpEF with high specificity (93%) and positive predictive value (98%). A low score can rule out HFpEF with a sensitivity of 99% and a negative predictive value of 73%. The diagnostic accuracy of the score is 0.90 (0.84–0.96), by the area under the curve of the receiver operating characteristic curve. However, 98 (36%) are classified in the intermediate‐likelihood category, where additional testing is advised. The distribution of the score shows a similar pattern in the Northwestern (Chicago) and Maastricht HFpEF patients (53% vs. 65% high, 43% vs. 34% intermediate, 4.8% vs. 1.3% low). Conclusion This study validates and characterizes the HFA‐PEFF score in two independent, well phenotyped cohorts. We demonstrate that the HFA‐PEFF score is helpful in clinical practice for the diagnosis of HFpEF.

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“…Of note, natriuretic peptides were not found to be predictive and are not included in this score. Unfortunately, as is often the case with scores of this type, an external validation raised doubts about its usefulness in less selected cohorts …”

Section: Comparison Of the H2fpef And Hfa‐peff Scoresmentioning

confidence: 99%

Diagnosing heart failure with preserved ejection fraction – what's the score?

Kristensen

McMurray

2020

European J of Heart Fail

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External Validation of the H ₂ F-PEF Model in Diagnosing Patients With Heart Failure and Preserved Ejection Fraction

Cited by 54 publications

References 5 publications

Application of the H₂FPEF score to a global clinical trial of patients with heart failure with preserved ejection fraction: the TOPCAT trial

Application of the H₂FPEF score to a global clinical trial of patients with heart failure with preserved ejection fraction: the TOPCAT trial

Validation of the HFA‐PEFF score for the diagnosis of heart failure with preserved ejection fraction

Diagnosing heart failure with preserved ejection fraction – what's the score?

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External Validation of the H 2 F-PEF Model in Diagnosing Patients With Heart Failure and Preserved Ejection Fraction

Cited by 54 publications

References 5 publications

Application of the H2FPEF score to a global clinical trial of patients with heart failure with preserved ejection fraction: the TOPCAT trial

Application of the H2FPEF score to a global clinical trial of patients with heart failure with preserved ejection fraction: the TOPCAT trial

Validation of the HFA‐PEFF score for the diagnosis of heart failure with preserved ejection fraction

Diagnosing heart failure with preserved ejection fraction – what's the score?

Contact Info

Product

Resources

About

External Validation of the H ₂ F-PEF Model in Diagnosing Patients With Heart Failure and Preserved Ejection Fraction

Application of the H₂FPEF score to a global clinical trial of patients with heart failure with preserved ejection fraction: the TOPCAT trial

Application of the H₂FPEF score to a global clinical trial of patients with heart failure with preserved ejection fraction: the TOPCAT trial