External Validation of the Recalibrated HEART Score for Evaluation of Possible Acute Coronary Syndrome

Suh, Edward Hyun; Mumma, Bryn E.; Einstein, Andrew J.; Chang, Betty C.; Huynh, Phong Anh; Rabbani, LeRoy E.; Ranard, Lauren S.; Sacco, Dana L.; Tichter, Aleksandr M.; Probst, Marc A.

doi:10.1016/j.amjcard.2024.08.005

The American Journal of Cardiology

2024

DOI: 10.1016/j.amjcard.2024.08.005

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External Validation of the Recalibrated HEART Score for Evaluation of Possible Acute Coronary Syndrome

Edward Hyun Suh,

Bryn E. Mumma,

Andrew J. Einstein

et al.

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Cited by 2 publications

References 28 publications

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Evaluating Patients With Chest Pain Using the Recalibrated HEART Score and a Single High Sensitive Cardiac Troponin Measurement

Bonarjee

2025

The American Journal of Cardiology

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Evaluating Patients With Chest Pain Using the Recalibrated HEART Score and a Single High Sensitive Cardiac Troponin Measurement

Bonarjee

2025

The American Journal of Cardiology

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High-Sensitivity Troponin: Finding a Meaningful Delta

Wright,

et al. 2024

JCDD

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High-sensitivity cardiac troponin (hs-cTn) assays have significantly refined the resolution of biomarker-level detection and have emerged as the gold standard cardiac biomarker in evaluating myocardial injury. Since its introduction, hs-cTn has been integrated into the Fourth Universal Definition of Myocardial Infarction and various European Society of Cardiology (ESC) and American College of Cardiology/American Heart Association (ACC/AHA) guidelines for the evaluation and diagnosis of chest pain syndromes. However, despite its integral role in caring for patients with chest pain, there are still substantive gaps in our knowledge of the clinical interpretation of dynamic changes in hs-cTn values. Whether a relative or absolute hs-cTn delta should be used to detect acute myocardial injury remains debatable. There are also emerging considerations of possible sex and racial/ethnic differences in clinically significant troponin deltas. In the emergency department, there is debate about the optimal time frame to recheck hs-cTn after symptom onset for myocardial infarction rule-out and whether hs-cTn deltas should be integrated into clinical risk scores. In this review, we will provide an overview of the history of clinical utilization of cardiac biomarkers, the development of hs-cTn assays, and the ongoing search for a meaningful delta that can be clinically applicable.

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External Validation of the Recalibrated HEART Score for Evaluation of Possible Acute Coronary Syndrome

Cited by 2 publications

References 28 publications

Evaluating Patients With Chest Pain Using the Recalibrated HEART Score and a Single High Sensitive Cardiac Troponin Measurement

Evaluating Patients With Chest Pain Using the Recalibrated HEART Score and a Single High Sensitive Cardiac Troponin Measurement

High-Sensitivity Troponin: Finding a Meaningful Delta

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