Externalizing spectrum or spectra? Underlying dimensions of the externalizing spectrum

Ingole, Ratnarakshit; Ghosh, Abhishek; Malhotra, Savita; Basu, Debasish

doi:10.1016/j.ajp.2015.04.011

Cited by 2 publications

(2 citation statements)

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“…Latent variable models capture the covariance among these behaviors with a factor commonly referred to as the externalizing spectrum (Achenbaeh TM and Edelbrock C, 1991; Krueger et al, 2005). While evidence suggests that aggressive/antisocial and substance use behaviors may represent separable subfactors within the externalizing spectrum, there is also substantial evidence indicating these facets are highly correlated and can be subsumed under a single factor (Ingole et al, 2015; Krueger et al, 2007; Poore et al, 2023). Together, such findings suggest that these behaviors have shared underlying mechanisms, but also raise the possibility of heterogeneity in the relations between these mechanisms and individual externalizing behaviors.…”

Section: Introductionmentioning

confidence: 99%

Executive Function as an Underlying Mechanism of Alcohol Use, Aggression, and ADHD

Spychala,

Friedman,

Gizer

2024

Preprint

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BackgroundExecutive functioning (EF) has been proposed as a transdiagnostic risk factor for externalizing disorders and behavior more broadly, including attention-deficit/hyperactivity disorder (ADHD), aggression, and alcohol use. Previous research has demonstrated both phenotypic and genetic overlap among these behaviors, but has yet to examine EF as a common causal mechanism. The current study examined reciprocal causal associations between EF and several externalizing behaviors using a Mendelian randomization (MR) approach.MethodsTwo-sample MR was conducted to test causal associations between EF and externalizing behaviors. Summary statistics from several genome-wide association studies (GWASs) were used in these analyses, including GWASs of EF, ADHD diagnostic status, drinks per week, aggressive behavior, and alcohol use disorder (AUD) diagnostic status. Multiple estimation methods were employed to account for horizontal pleiotropy (e.g., inverse variance weighted, MR-PRESSO, MR-MIX).ResultsEF demonstrated significant causal relationships with ADHD (P < 0.01), AUD (P < 0.03), and alcohol consumption (P < 0.01) across several estimation methods. Reciprocally, ADHD showed a significant causal influence on EF (P < 0.03). Nonetheless, caution should be used when interpreting these findings as there was some evidence for horizontal pleiotropy in the effect of EF on ADHD and significant heterogeneity in variant effects in the other relations tested. There were no significant findings for aggression.ConclusionsFindings suggest that EF may be a causal mechanism underlying some externalizing behaviors, including ADHD and alcohol use, and that ADHD may also lead to lower performance on EF tasks.

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Section: Introductionmentioning

confidence: 99%

Executive Function as an Underlying Mechanism of Alcohol Use, Aggression, and ADHD

Spychala,

Friedman,

Gizer

2024

Preprint

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“…Os TDCID envolvem traços de personalidade que denotam baixa desinibição, maior hostilidade e maior afeto negativo (Ingole, Ghosh, Malhotra, & Basu, 2015). Na última edição do Manual Diagnóstico e Estatístico dos Transtornos Mentais (DSM; American Psychiatric Association -APA, 2013), o transtorno de conduta (TC), transtorno de oposição desafiante (TOD), cleptomania, transtorno explosivo intermitente (TEI) e outros transtornos disruptivos especificados e não especificados (TD) estão agrupados dentro da seção "Transtornos Disruptivos, do Controle de Impulsos e da Conduta".…”

Section: Introductionunclassified

Problemas de Conduta em Crianças e Adolescentes: Evidências no Brasil

Wendt

Koller

2019

RPI

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O presente estudo realizou uma revisão sistemática da literatura nacional sobre Transtornos Disruptivos, do Controle de Impulsos e da Conduta (TDCID) entre crianças e adolescentes brasileiros. Após a consideração dos critérios de inclusão, de exclusão e busca manual nas referências dos artigos, dez estudos foram revisados. Cinco foram do tipo estudo de caso, quatro assumiram a forma de delineamento transversal e apenas um teve o delineamento naturalístico. Dentre os TDCID, o Transtorno de Conduta foi o mais prevalente, tanto em amostras clínicas como não-clínicas. Houve elevada ocorrência de comorbidade entre os TDCID e transtornos afetivos, de aprendizagem e uso de substâncias. Todavia, dado o montante de investigações disponível atualmente, não foi possível descrever, com precisão, acerca dos possíveis fatores desenvolvimentais de mudança e continuidade em relação aos TDCID entre crianças e adolescentes do Brasil. Salienta-se, assim, acerca da necessidade de realização de novos estudos, utilizando múltiplos desenhos de pesquisa, com vistas a melhor caracterizar fatores de risco e de proteção associados aos transtornos avaliados.

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Externalizing spectrum or spectra? Underlying dimensions of the externalizing spectrum

Cited by 2 publications

References 35 publications

Executive Function as an Underlying Mechanism of Alcohol Use, Aggression, and ADHD

Executive Function as an Underlying Mechanism of Alcohol Use, Aggression, and ADHD

Problemas de Conduta em Crianças e Adolescentes: Evidências no Brasil

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