Extra-abdominal desmoid fibromatosis: A review of management, current guidance and unanswered questions

Eastley, Nicholas; McCulloch, Tom; Esler, C.; Hennig, I.; Fairbairn, John F.; Gronchi, A.; Ashford, Robert U.

doi:10.1016/j.ejso.2016.02.012

Cited by 67 publications

(87 citation statements)

References 87 publications

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“…The World Health Organization defines desmoid-type fibromatosis as an intermediate soft-tissue tumor that is characterized by clonal fibroblastic proliferation arising in the deep soft tissues, with a tendency for infiltration of the local tissues and local recurrence, but an inability to metastasize (1). Cases of desmoid-type fibromatosis are often broadly categorized into one of two groups.…”

Section: Discussionmentioning

confidence: 99%

“…Desmoid-type fibromatosis, previously described as aggressive fibromatosis, is a rare soft tissue tumor with the typical clinical behavior of frequent local recurrence without distant spread (1). It usually occurs in the abdominal wall and in the superficial muscular-aponeurotic tissues of the extremities (1–3).…”

Section: Introductionmentioning

confidence: 99%

“…It usually occurs in the abdominal wall and in the superficial muscular-aponeurotic tissues of the extremities (1–3). Mammary desmoid-type fibromatosis is a rare and locally aggressive intermediate tumor of the breast; it originates from fibroblasts and myofibroblasts within the breast parenchyma and does not metastasize (1–5). The condition is locally aggressive and has a high rate of recurrence.…”

Section: Introductionmentioning

confidence: 99%

“…The condition is locally aggressive and has a high rate of recurrence. Extra-abdominal desmoid tumors account for 3% of all soft-tissue tumors, with an incidence of 2.4–4.3 per million each year (1). Fibromatosis of the chest wall represents 8–10% of all cases (2).…”

Section: Introductionmentioning

confidence: 99%

“…The etiology of mammary fibromatosis is unknown, and breast imaging examinations are not specific for fibromatosis; to distinguish mammary fibromatosis from malignant breast tumors through physical examination and imaging techniques can be difficult. There appears to be general agreement that a complete wide excision is the treatment of choice of fibromatosis involving only the breast (1–4). The current study presents 2 cases of women with breast fibromatosis, including one with a locally advanced aggressive form of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Desmoid-type fibromatosis of the breast: A report of 2 cases

2017

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Mammary fibromatosis is a rare and locally aggressive benign tumor of the breast; it originates from fibroblasts and myofibroblasts within the breast parenchyma and does not metastasize. The condition is locally aggressive and has a high rate of recurrence. The etiology of mammary fibromatosis is unknown. Breast imaging examinations are not specific for fibromatosis and often imitate breast cancer. The current study presents 2 cases of women with breast fibromatosis, the first of which exhibited a locally advanced aggressive form of the disease, where breast surgery and en bloc resection of the underlying regions of the thoracic wall were required. In the second case, breast imaging examinations suggested an invasive breast tumor, probably carcinoma, infiltrating the muscles of the chest wall. An ultrasound-guided core needle biopsy revealed a low-grade myofibroblastic proliferation consistent with breast fibromatosis. The patient underwent a right quadrantectomy, with a partial resection of the underlying musculature. The patients remain disease-free at the time of writing. As involvement of the breast in patients with desmoid-like fibromatosis as rare, the present study reports 2 cases with clinical features and histological findings in order to improve and add to the knowledge of this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Desmoid-type fibromatosis of the breast: A report of 2 cases

2017

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Paraspinal desmoid fibromatosis after lumbar epidural analgesia

Remedios

Sommerfield

Fellingham

et al. 2021

Anaesthesia Reports

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A 14-year-old girl with cerebral palsy presented for bilateral lower limb surgery for spasticity. A lumbar epidural catheter was sited under general anaesthesia on the third attempt and used intra-operatively with good effect. A local anaesthetic infusion was used for postoperative analgesia but was noted to be leaking under the dressing with a patchy, unilateral block. The catheter was therefore removed on the second postoperative day. Following discharge, the patient progressively developed new back and leg pain for which she was re-admitted seven weeks later. This was investigated and initially thought to be myositis of the erector spinae muscles on magnetic resonance imaging. When the patient failed to respond to treatment, a muscle biopsy demonstrated desmoid fibromatosis. Trauma may cause or accelerate the development of desmoid fibromatosis, which has also been theorised to arise from scar tissue in previously injured areas. We hypothesise that challenging epidural placement or the leakage of the local anaesthetic agent into the surrounding muscular tissue, inducing local myonecrosis, could have been the triggering or accelerating event in tumour development. This may be the first reported case of extra-abdominal desmoid fibromatosis in association with epidural placement.

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