Extra-Abdominal Desmoid Tumors Associated with Familial Adenomatous Polyposis

Calvert, George T.; Monument, Michael J.; Burt, Randall W.; Jones, Kevin B.; Randall, R. Lor

doi:10.1155/2012/726537

Cited by 12 publications

(10 citation statements)

References 71 publications

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“…They can be diagnosed at any age, but are more common in young people (10–40 years), and are slightly more frequent in women than in men. Most DFs arise sporadically; some are related to pregnancy and trauma, and others appear as part of a syndrome with colonic polyposis, osteomas, and soft tissue tumours …”

Section: Introductionmentioning

confidence: 99%

Nuclear GSK‐3β segregation in desmoid‐type fibromatosis

Meneghello¹,

Ousghir²,

Rastrelli

et al. 2013

Histopathology

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Section: Introductionmentioning

confidence: 99%

Nuclear GSK‐3β segregation in desmoid‐type fibromatosis

Meneghello¹,

Ousghir²,

Rastrelli

et al. 2013

Histopathology

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“…Recurrence is often problematic, as there are no clear treatments indicated for DF recurrence [17]. We conducted an investigation into factors involved in DF recurrence using immunohistochemistry and discovered that COX-2 expression was significantly associated with recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the unpredictable natural history of the disease, it is difficult to establish a treatment regimen for DF [17]. Historically, surgery was the main treatment with or without radiation therapy [2,17].…”

Section: Introductionmentioning

confidence: 99%

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Possible involvement of cyclooxygenase-2 in the recurrence of desmoid fibromatosis: case series and mini-review of the literature

Hashimoto¹,

Nishimura²,

Oka³

et al. 2018

biomedicalresearch

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Background: Desmoid fibromatosis (DF) is a type of fibrous tumor that rarely metastasizes but often recurs locally. Cyclooxygenase-2 (COX-2) has been shown to be expressed in DF lesions, although its involvement in DF recurrence is unknown. We investigated the association between COX-2 expression and DF recurrence using immunohistochemistry. Patients and methods: Cases of DF treated in our hospital between March 2000 and December 2012 were reviewed. We used immunohistochemistry to identify COX-2 expression in resected specimens from these cases. The relationship between recurrence and age, sex, duration of disease, size of tumor, tumor site, spontaneous pain, inflammation, and COX-2 expression was studied. Results: In the ten included cases (mean age, 55.2 y; 5 male and 5 female patients), we found that COX-2 expression was significantly associated with DF recurrence (p=0.01). Conclusion: Our findings indicate that COX-2 is involved in recurrence of DF.

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“…Two different types of DTs are described: sporadic ones and those associated with familial adenomatous polyposis (FAP). This manifestation accounts for 5–10% of DF [ 4 ]. There is no sex predilection and the average age at disease development is 30–40 years [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Primary Asymptomatic Desmoid Tumor of the Mesentery

et al. 2015

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Patient: Male, 40Final Diagnosis: Mesenteric desmoid tumorSymptoms: Abdominal massMedication: —Clinical Procedure: Laparotomy exploratorySpecialty: SurgeryObjective:Rare diseaseBackground:Desmoid-type fibromatosis (DF) is a rare entity that predominantly involves the extremities, the trunk, and the abdominal cavity. It is a non-metastasizing, sporadic mesenchymal tumor with high tendency to recurrence and often is categorized as low-grade sarcoma.Case Report:We present here an extremely rare case of a mesenteric desmoid tumor (DT). A 40-year-old man presented to our clinic with a mass in the right-lower quadrant of the abdomen, which he incidentally palpated. A computerized tomography (CT) scan of the abdomen showed a mass between the loops of small intestine. The patient was treated successfully with wide excision of involved mesentery and adjacent small intestine. Histopathology of the mass revealed DT of the mesentery. No adjuvant treatment was applied and the patient was free of disease after a 6-month follow-up.Conclusions:Intra-abdominal DF is a rare pathology which should be differentiated while exploring abdominal tumors. Surgery, when dealing with operable masses, is the appropriate treatment.

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Extra-Abdominal Desmoid Tumors Associated with Familial Adenomatous Polyposis

Cited by 12 publications

References 71 publications

Nuclear GSK‐3β segregation in desmoid‐type fibromatosis

Nuclear GSK‐3β segregation in desmoid‐type fibromatosis

Possible involvement of cyclooxygenase-2 in the recurrence of desmoid fibromatosis: case series and mini-review of the literature

Primary Asymptomatic Desmoid Tumor of the Mesentery

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