Extra‐adrenal pheochromocytoma 12 years in the making

Nicoleau, A; Siskind, S; Resta, Christine; Noordhoorn, M; Turner, James; Saw, Daisy

doi:10.1111/j.1445-5994.2007.01565.x

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…In case of preoperative misdiagnosis of functional retroperitoneal paragangliomas, the anesthesia procedures and intraoperative manipulation of the tumor may cause a release of catecholamines, which could have a negative impact on patient outcomes [3, 5, 14, 15]. Thus far, few case reports have described such operations with negligible complications intraoperatively and postoperatively, while there are no large-sample relevant assessments conducted [10, 14, 16, 17]. Therefore, the aim of the present retrospective study was to verify whether patients with extra-adrenal retroperitoneal paragangliomas who do not receive preoperative α-adrenergic blockade therapy are linked to poor outcomes.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Alpha-Blocker Therapy in Patients with Missed Preoperative Diagnosis of Extra-Adrenal Retroperitoneal Paraganglioma Undergoing Resection: A Retrospective Study of 167 Cases at a Single Center

Liu

Jin²,

Gao

et al. 2021

Neuroendocrinology

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Introduction: Preoperative α-adrenergic blockade is thought to decrease perioperative risks and mortality in surgeries for adrenal pheochromocytoma. However, there are limited data on the efficacy of α-blockers in surgeries for retroperitoneal paragangliomas. The aim of this study was to evaluate the effects of the preoperative α-adrenergic blockade on outcomes in patients undergoing surgery for extra-adrenal retroperitoneal paraganglioma. Methods: We searched the clinical database for patients diagnosed with extra-adrenal retroperitoneal paraganglioma by postoperative histopathology in the General Hospital of People’s Liberation Army in China from 2000 to 2017. We compared the preoperative status of patients, preoperative examination, preoperative preparation, intraoperative and postoperative cardiovascular events, intake and output, length of stay in the intensive care unit, length of hospital stays, and short-term outcomes between patients who received preoperative treatment with α-adrenergic blockade and those who did not. Results: Of the 167 patients enrolled in the study, 61 received preoperative α-adrenergic blockade therapy. Intraoperative heart rate elevation and highest heart rate were higher in patients undergoing tumor manipulation with preoperative α-adrenergic blockade than those who did not (p < 0.05). However, there were no significant differences between these 2 groups in terms of intraoperative blood pressure elevation and systolic blood pressure decrease following tumorectomy (p > 0.05). Moreover, there were no significant differences in postoperative complications and outcomes (p > 0.05). Conclusion: Under the current medical practice, resection of extra-adrenal retroperitoneal paraganglioma can be successfully carried out with or without preoperative α-adrenergic blockade.

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Section: Introductionmentioning

confidence: 99%

Preoperative Alpha-Blocker Therapy in Patients with Missed Preoperative Diagnosis of Extra-Adrenal Retroperitoneal Paraganglioma Undergoing Resection: A Retrospective Study of 167 Cases at a Single Center

Liu

Jin²,

Gao

et al. 2021

Neuroendocrinology

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Is there a need for preoperative α-blocker in patients missed preoperative diagnosis of extra-adrenal retroperitoneal paraganglioma undergoing paraganglioma resection? A retrospective study of 167 cases at a single center

Liu

Jin

Gao

et al. 2020

Preprint

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BackgroundPreoperative α-adrenergic blockade is believed to decrease perioperative risks and mortality in adrenal pheochromocytoma surgeries. The aim of this study is to evaluate the effects of the preoperative α-adrenergic blockade on patients’ outcomes in extra-adrenal retroperitoneal paraganglioma surgeries.MethodsWe searched our clinical database for the diagnosis extra-adrenal retroperitoneal paraganglioma by postoperative histopathology in the General Hospital of People’s Liberation Army from 2000 till 2017. And we recorded preoperative status of patients, preoperative medication preparation, intraoperative and postoperative cardiovascular events, intake and output, length of stay in ICU, length of hospital stay, and short time outcomes.ResultsThe intraoperative morbidity of heart rate elevation and highest heart rate were higher in patients undergoing tumor manipulation with preoperative α-adrenergic blockade than those without (P<0.05), while there were no significant differences in intraoperative morbidity of blood pressure elevation and SAP decreased following tumorectomy in these two groups (P>0.05). There were no significant differences in postoperative complications and outcomes (P>0.05).ConclusionUnder the current medical techniques, either with or without preoperative medicine, resection of extra-adrenal retroperitoneal paraganglioma could be carried out successfully.

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Hipertensión secundaria a paraganglioma: presentación de un caso y revisión de la literatura

Rubio-Marín

Orjuela

Rascovsky

et al. 2016

iatreia

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Se presenta el caso de un hombre de 25 años, con historia de accidente cerebrovascular transitorio durante la adolescencia, e hipertensión arterial no controlada de larga data, que consultó por palpitaciones, diaforesis y cefalea holocraneana. Se le diagnosticó y confirmó por histopatología un paraganglioma paraórtico hipersecretor de catecolaminas. Los síntomas se resolvieron completamente después de la extracción del tumor. El paraganglioma es un tumor extraadrenal infrecuente derivado de las células cromafines; se lo considera como un diagnóstico relevante en la evaluación de la hipertensión arterial secundaria. Se presenta una revisión de la literatura de casos de paragangliomas hipersecretores de catecolaminas cuyo síntoma asociado fue la hipertensión arterial.

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Extra‐adrenal pheochromocytoma 12 years in the making

Cited by 3 publications

References 5 publications

Preoperative Alpha-Blocker Therapy in Patients with Missed Preoperative Diagnosis of Extra-Adrenal Retroperitoneal Paraganglioma Undergoing Resection: A Retrospective Study of 167 Cases at a Single Center

Preoperative Alpha-Blocker Therapy in Patients with Missed Preoperative Diagnosis of Extra-Adrenal Retroperitoneal Paraganglioma Undergoing Resection: A Retrospective Study of 167 Cases at a Single Center

Is there a need for preoperative α-blocker in patients missed preoperative diagnosis of extra-adrenal retroperitoneal paraganglioma undergoing paraganglioma resection? A retrospective study of 167 cases at a single center

Hipertensión secundaria a paraganglioma: presentación de un caso y revisión de la literatura

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