Extra-anogenital giant cutaneous squamous cell carcinomas require multidisciplinary management

Dam, Pieter-Jan van; Trinh, Xuan Bich; An, Bervoets; Lambert, Julien

doi:10.1016/j.ctarc.2021.100413

Cited by 1 publication

(19 citation statements)

References 71 publications

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“…Contrary to giant SCCs developing in anogenital regions, giant cSCCs arising in other locations are rarely reported [ 3 ]. In 2012, Wollina et al [ 4 ] analyzed their collected data and performed research on all histologically confirmed non-melanoma skin cancers (NMSCs).…”

Section: Discussionmentioning

confidence: 99%

“…cSCC can become a giant tumor in case of delayed treatment due to not being noticed or being neglected by the patient [ 3 ]. The latter is commonly associated with advanced age, low socioeconomic status, poor hygiene, and fear of being diagnosed [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…In 2021, van Dam et al [ 3 ] performed a systematic literature search on extra-anogenital cSCCs and analyzed 42 cases they identified. In total, 24 (57.1%) out of 42 patients were male.…”

Section: Discussionmentioning

confidence: 99%

“…The number of cSCC cases has increased over recent years, making it a health issue of global importance [ 2 ]. cSCCs can become a giant tumor in case of delayed treatment due to not being noticed or being neglected by the patient [ 3 ]. By definition, a giant is referred to as a tumor whose maximum clinical diameter is at least 5 cm [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Extra-anogenital giant cSCCs are rarely reported in the literature. Considering the rarity and absence of prospective randomized trials, consistent recommendations for medical management do not exist [ 3 ]. Prompted by the limited data, we conducted this study to gather more information about giant cSCCs to optimize clinical care.…”

Section: Introductionmentioning

confidence: 99%

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Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas

Mateuszczyk,

Chlebicka,

Łyko

et al. 2024

Life

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Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a review of cSCC cases treated in the Unit of Dermatosurgery between 2016 and 2022. Most patients were male (85.71%) with a mean age of 80.29 ± 12.22 years. UV radiation was the most common risk factor (five cases) followed by smoking (three cases) and hidradenitis suppurativa (one case). Most giant cases were located in the head area (71.4%) and the diameter of lesions ranged from 6 to 18 cm. All patients corresponded to tumor stage T3, and 42.86% of patients had lymph node metastases. Surgical excision was the treatment of choice in most cases (85.71%), while a combination of cemiplimab and RP1 was used in some cases due to the ineffectiveness of treatment or contraindications to other therapies. The authors emphasize the importance of early detection and prevention of modifiable risk factors, such as UV radiation, and a multidisciplinary approach to treatment. Other therapies, including immunotherapy, may become increasingly important.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…In 2021, van Dam et al [ 3 ] performed a systematic literature search on extra-anogenital cSCCs and analyzed 42 cases they identified. In total, 24 (57.1%) out of 42 patients were male.…”

Section: Discussionmentioning

confidence: 99%