Extra-articular features in early rheumatoid disease.

Fleming, A; Dodman, Sophie; Crown, June; Corbett, Mary

doi:10.1136/bmj.1.6020.1241

Cited by 47 publications

(28 citation statements)

References 6 publications

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“…In our RA patients without any clinically observed neurological deficit, 6% demonstrated CTS and 18% MNM. These are much lower than the results of Fleming et al [8], who found median nerve entrapment in 52% of RA patients whose mean disease duration was 4.5 years. Lang et al [3] found manifest or subclinical mononeuropathies of the median nerve in five of their 23 RA patients.…”

Section: Discussioncontrasting

confidence: 74%

The electroneurophysiological evaluation of Rheumatoid Arthritis patients

Sívrí

Güler-Uysal

1998

Clin Rheumatol

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In Rheumatoid Arthritis (RA), one clinical hallmark of the vasculitis is the appearance of neurological findings. However, it is often difficult to diagnose these slight or early neuropathies and the study of the peripheral neuromuscular system is often made difficult by symptoms resulting from pain in the joints, and limitations of movement. It is nevertheless often possible, by means of electroneuromyography to show objectively the existence and distribution of even subclinical neuropathies. In order to evaluate the neurophysiological functions of RA patients by means of the peripheral nerve conduction and somatosensory evoked potential studies, 33 RA patients and 20 healthy controls were included in this study. Two (6%) patients were found to have carpal tunnel syndrome, while 6 (18%) patients had mononeuritis multiplex. Delayed N12, N13, N1 and P1 latencies were detected in 6 (18%) of 33 RA patients suggesting central nervous system involvement with intact peripheral nervous system. Our results confirm earlier observations that symptoms of neuropathy are fairly common in cases of RA without there being any clear correlation with any clinical variable. Therefore, the inclusion of an electroneurophysiologic examination of the RA patients is recommended in routine diagnostic procedure.

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Section: Discussioncontrasting

confidence: 74%

The electroneurophysiological evaluation of Rheumatoid Arthritis patients

Sívrí

Güler-Uysal

1998

Clin Rheumatol

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“…The prevalence of peripheral neuropathy and its related factors vary among previous studies, as shown in Table 5 [5,6,14,15,16]. Furthermore, it is difficult to compare studies examining peripheral neuropathy in RA because the inclusion criteria and neuropathy assessment methods varied between previous reports.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Peripheral Neuropathy in Patients With Rheumatoid Arthritis Who Complain of Neurologic Symptoms

et al. 2014

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ObjectiveTo assess the prevalence of peripheral neuropathy in patients with rheumatoid arthritis (RA) having neuropathic symptoms, and to investigate the relationship between electrophysiological findings of peripheral neuropathy and clinical findings of RA.MethodsPatients with a clinical diagnosis of RA and who had tingling or burning sensation in any extremity were electrophysiologically examined for evidence of peripheral neuropathy. Study parameters, including age, gender, laboratory parameters, duration of RA, and medication, were recorded. The symptoms and signs of neuropathy were quantified with the neuropathy symptom score, and the functional statuses of these patients were assessed.ResultsOut of a total of 30 RA patients, 10 (33%) had peripheral neuropathy: 2 had bilateral carpal tunnel syndrome (CTS), 5 had unilateral CTS, 1 had sensory polyneuropathy, and 2 had motor-sensory polyneuropathy. The mean ages of the patients with and without peripheral neuropathy were 69.4 and 56.5 years, respectively (p<0.05). A significant relationship was found between peripheral neuropathy and anti-cyclic citrullinated peptide (anti-CCP) antibody. However, no relationship was found between peripheral neuropathy and the type of medication, RA duration, the patients' functional status, neuropathic symptoms, erythrocyte sedimentation rate, and C-reactive protein values.ConclusionNeuropathic symptoms are common in RA patients, and it is difficult to distinguish peripheral neuropathy symptoms from those of arthritis. Patients with RA, particularly elderly patients and anti-CCP antibody positive patients who complain of neuropathic symptoms should undergo electrophysiological examination.

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“…The material for this paper is taken from the Middlesex Hospital Prospective Study of Early (Fleming et al, 1975(Fleming et al, , 1976.…”

Section: Methodsmentioning

confidence: 99%

“…The patients were divided into three prognostic categories on the basis of functional grade, extent of joint involvement, grip strength, and duration of early morning stiffness (Fleming et al, 1976). These categories were 'improved', 'mild', and 'severe', but for the purpose of this analysis the first two have been considered together as 'mild'.…”

Section: Methodsmentioning

confidence: 99%