Extra-cellular matrix changes in Schistosoma mansoni-infected Biomphalaria glabrata

Borges, Claudia Maria da Cunha; Andrade, Zilton de Araújo

doi:10.1590/s0074-02762003000100017

Cited by 8 publications

(9 citation statements)

References 23 publications

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“…The present light microscopic observations of the interaction between sporocysts of S. haematobium and B. truncatus snail tissue generally agree with similar studies of sporocysts in natural or susceptible hosts (Sminia and Barendsen, 1980;Arfaa et al, 1989;Lemos, 1999;Borges and Andrade, 2003). Electron microscope studies of the relation between sporocysts and snail cells are limited and possibly rare.…”

Section: Discussionsupporting

confidence: 85%

“…Although Yoshino (1976) and Krupa et al (1977) noted that the presence of extracellular fibrils contributed to the formation of the encapsulating lesions, Harris (1975) did not find extracellular elements associated with the molluscan cellular reactive responses. One probable cause of this divergence could be the presence of true collagen and orcein-positive elastic fibers only at the periphery of the lesions as noted recently by Borges and Andrade (2003). Both at light and electron microscopy, collagen-like fibers are noted at the proximity of hemocytes accumulations.…”

Section: Discussionmentioning

confidence: 78%

“…Fibers with staining characteristics of collagen or elastin have been demonstrated in normal snail tissues (Lemos, 1999;Borges and Andrade, 2003). However, the presence of elements from the extracellular matrix in the granulomatous lesions of Biomphalaria glabrata against Schistosoma mansoni has been a controversial issue.…”

Section: Discussionmentioning

confidence: 99%

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Histopathological study on susceptible and resistant Bulinus truncatus snails to infection with Schistosoma haematobium

Saad¹,

Gawish²,

El-Einin³

et al. 2013

Afr. J. Pharm. Pharmacol.

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In this study, the distribution pattern of Schistosoma haematobium miracidia level to host susceptibility/resistance and the basic cellular responses during the parasite development was investigated. Several snail stocks showed a wide spectrum of host reaction to the parasite. A vigorous "resistant-type" cellular response to invading miracidia was seen in the histological sections of non-susceptible snails. In this respect, they were classified as "resistant snails". Bulinus truncatus infected with S. haematobium exhibited a wide range of histopathological change, suggesting the presence of endogenous factors preventing the immune system of susceptible snails from destroying the developed parasite larvae. Therefore, the mechanism underlying the susceptibility of the snails should be investigated by studying the host-parasite interactions by light and electron microscopy.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 78%

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Histopathological study on susceptible and resistant Bulinus truncatus snails to infection with Schistosoma haematobium

Saad¹,

Gawish²,

El-Einin³

et al. 2013

Afr. J. Pharm. Pharmacol.

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“…1983;Ottoviani, 1989, Giamberini et ai, 1996and Borges and Andrade, 2003. The chronic effect of E. peplm showed a slight decrease in circulating haemocytes after the first week of exposure.…”

Section: Discussionmentioning

confidence: 97%

Effect of Euphorbia Peplus Plant Extract and the Antihelmenthic Prazequantel on the Defence System of Biomphalaria Alexandria Snail

Helal

ElMehlawy

Rizk

et al. 2003

Egypt. J. of Aquatic Biolo. and Fish.

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T he effect of sublethal concentrations of£ pephis water suspension and praziquantel water solution on the defense system of Biomphalaria cdexandrina was examined by laboratory experiments.The mean number of haemocytes decreased insignificantly after the first week of snail exposure to the plant extract-Thereafter, a significant increase occurred after the second week of exposure. Treatment with praziquantel showed a significant increase in haemocytes after the 3 rd and 4 lh weeks of exposure. Haemocytosis represents a response to external stress or certain stimuli. The haemocytes showed behavioral as well as structural changes after long exposure to the tested mollusclcides. The cells had many cytoplasmic inclusions and produce many long spike-like pseudopodia. Haemocytes exhibited an enhanced tendency to aggregate in clusters. Such alterations may be indicative of a state of haemocytes activation. The total plasma protein concentration after treatment with E. pephis and Praziquantel increased plasma than in control snails while no changes in protein concentration of the digestive gland extract. This may be a result of an imbalance in the rate of protein synthesis and the rate of its degradation.The treatment with E peplus and Praziquantel caused a marked increase in acid phosphatase after the 2nd and 4 lh weeks. On the other hand, alkaline phosphatase activity increased after the 4 th week. This could be explained as defensive and lysosomal activity of the haemocytes. After treatment with the tested substances the plasma and digestive gland extract were capable to agglutinate sheep red 502

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“…So they frequently present lysossomes ready to pour their digestive enzymes, among them several acid hydrolyses, into phagocytic vacuoles. These aspects have already been studied (Carter & Bogitsh 1975, Folley & Cheng 1977, Cheng 1983, Borges & Andrade 2003. However, two aspects now observed deserve comments.…”

Section: Discussionmentioning

confidence: 85%

A contribution to the pathobiology of Biomphalaria glabrata hemocytes

Borges

Azevedo

Andrade

2006

Mem. Inst. Oswaldo Cruz

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Extra-cellular matrix changes in Schistosoma mansoni-infected Biomphalaria glabrata

Cited by 8 publications

References 23 publications

Histopathological study on susceptible and resistant Bulinus truncatus snails to infection with Schistosoma haematobium

Histopathological study on susceptible and resistant Bulinus truncatus snails to infection with Schistosoma haematobium

Effect of Euphorbia Peplus Plant Extract and the Antihelmenthic Prazequantel on the Defence System of Biomphalaria Alexandria Snail

A contribution to the pathobiology of Biomphalaria glabrata hemocytes

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