“Extra-Cranial” Manifestations of Giant Cell Arteritis

Daumas, Aurélie; Bernard, F.; Rossi, P.; Granel, B.

doi:10.5772/22116

Cited by 2 publications

(2 citation statements)

References 67 publications

(59 reference statements)

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“…A Spanish case report described a 76‐year‐old female patient with pectoral girdle pain and a pleural effusion on x‐ray who was eventually diagnosed with polymyalgia rheumatica (PMR) accompanied by pleuropericarditis and whose high levels of CA‐125 indicated serosal involvement, rather than malignancy . Based on these observations, it has been suggested that while investigating idiopathic pericarditis among elderly patients, a temporal artery biopsy should be obtained even in the absence of classical GCA manifestations . Current guidelines note that pericarditis, acute or recurrent, reflects the presence of systemic autoimmune disease in 5% to 15% of the cases; in such suspected cases, the authors warrant a targeted search for etiology and recommend gaining rapid control over the primary disease.…”

Section: Discussionmentioning

confidence: 99%

Pericarditis among giant cell arteritis patients: From myth to reality

Tiosano

Adler

Azrielant

et al. 2018

Clinical Cardiology

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Background Giant cell arteritis (GCA) is an inflammatory disease of unknown etiology affecting adults age > 50 years. GCA (also known as temporal arteritis) is a vasculitis of large and medium‐size vessels that involves the extracranial branches of the carotid artery. Common manifestations include constitutional symptoms, headache, jaw claudication, scalp tenderness, and vision loss. Cardiac involvement in GCA is considered to be as low as 5%, and < 30 cases of pericarditis among GCA patients have been reported in the literature. The aim of this study was to evaluate the association between GCA and pericarditis by conducting a cross‐sectional study utilizing the database of the largest healthcare provider in Israel. Hypothesis GCA is associated with pericarditis. Methods The proportion of past documentation of pericarditis among patients diagnosed with GCA was compared with that of their age‐ and sex‐matched controls. Univariate analysis was performed using the χ2 and t tests; multivariate analysis was performed using logistic regression. Results The study included 4329 GCA patients and 21 611 controls. GCA patients had higher rates of cardiovascular risk factors. Pericarditis was observed in 53 GCA patients and 72 controls (1.22% vs 0.33%, respectively; P < 0.001), significantly higher among GCA patients in comparison with controls. A significant interaction was found between GCA, pericarditis, and young age (<70 years). Conclusions The study showed an independent association between GCA and pericarditis, especially among young patients. Proper screening should be applied whenever a suspicion arises as to the existence of comorbidity in patients with either disease.

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Section: Discussionmentioning

confidence: 99%

Pericarditis among giant cell arteritis patients: From myth to reality

Tiosano

Adler

Azrielant

et al. 2018

Clinical Cardiology

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“…3,4 Large vessel vasculitis (LVV) affecting the aorta and its branches is now recognized as part of the GCA phenotype and is observed in 30% to 67.5% of patients. [5][6][7][8][9] Glucocorticoids (GCs) are the first-line treatment and should be started as soon as the diagnosis is made to prevent the risk of ischemic complications, particularly permanent visual loss or cerebrovascular events. Because long-term GC therapy leads to several adverse effects, French recommendations consider discontinuing GC after 18 to 24 months of treatment.…”

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confidence: 99%

Predictors of Relapses or Recurrences in Patients With Giant Cell Arteritis

et al. 2023

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Objective: Giant cell arteritis (GCA) is the most common systemic vasculitis in individuals aged ≥50 years. Its course is marked by a high relapse rate requiring long-term glucocorticoid use with its inherent adverse effects. We aimed to identify factors associated with relapses or recurrences in GCA at diagnosis. Methods:We reviewed the medical records of consecutive patients with GCA diagnosed between 2009 and 2019 and followed for at least 12 months. We recorded their characteristics at onset and during follow-up. Factors associated with relapses or recurrences were identified using multivariable analysis. Results:We included 153 patients, among whom 68% were female with a median age of 73 (47-98) years and a median follow-up of 32 (12-142) months. Seventy-four patients (48.4%) had at least 1 relapse or recurrence. Headache and polymyalgia rheumatica were the most frequent manifestations of relapses. The first relapse occurred at a median time of 13 months after the diagnosis, with a median dose of 5.5 (0-25) mg/d of glucocorticoids.In multivariable analysis, patients with relapses or recurrences had a higher frequency of cough and scalp tenderness at diagnosis (20.3% vs 5.1%; odds ratio [OR], 4.73; 95% confidence interval [CI], 1.25-17.94; p = 0.022; and 41.9% vs 29.1%; OR, 2.4; 95% CI, 1.07-5.39; p = 0.034, respectively). Patients with diabetes mellitus at diagnosis had fewer relapses or recurrences during follow-up (5.4% vs 19%; OR, 0.24; 95% CI, 0.07-0.83; p = 0.024).Conclusions: Cough and scalp tenderness at diagnosis were associated with relapses or recurrences, whereas patients with diabetes experienced fewer relapses or recurrences.

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“Extra-Cranial” Manifestations of Giant Cell Arteritis

Cited by 2 publications

References 67 publications

Pericarditis among giant cell arteritis patients: From myth to reality

Pericarditis among giant cell arteritis patients: From myth to reality

Predictors of Relapses or Recurrences in Patients With Giant Cell Arteritis

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