Extra-Esophageal Disorders in Gastroesophageal Reflux Disease

Jaspersen, D

doi:10.1159/000080309

Cited by 28 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A major advance in the understanding of extra-esophageal manifestations comes from the recognition that a significant number of patients with asthma or chronic cough, particularly if it is nocturnal, have gastroesophageal reflux as a trigger. [1] Extra-esophageal symptoms of GERD are highly prevalent among patients with both frequent and infrequent typical GERD symptoms.…”

Section: Pulmonary Manifestations Of Gerdmentioning

confidence: 99%

“…The kind of GERD disease, weight and gender did not have significant relationship with asthma. [1] A recent systematic review[3] of 28 epidemiological studies found a 59.2% weighted average prevalence of GERD symptoms in asthmatic patients, compared to 38.1% in controls. The corresponding prevalence of asthma in GERD patients was 4.6%, compared to 3.9% in controls.…”

Section: Prevalencementioning

confidence: 99%

“…There is evidence that 2 months with PPI is sufficient to reduce cough in patients with GERD. [2] Jaspersen[1] found that GERD-related cough nearly always improves with PPI treatment. Available evidence supports the use of PPI with doubled standard doses for at least 12 weeks in GERD-related cough.…”

Section: Management Of Gerd In Patients With Pulmonary Manifestationsmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary manifestations of gastroesophageal reflux disease

Gaude

2009

Ann Thorac Med

108

View full text Add to dashboard Cite

Gastroesophageal reflux disease (GERD) may cause, trigger or exacerbate many pulmonary diseases. The physiological link between GERD and pulmonary disease has been extensively studied in chronic cough and asthma. A primary care physician often encounters patients with extra esophageal manifestations of GERD in the absence of heartburn. Patients may present with symptoms involving the pulmonary system; noncardiac chest pain; and ear, nose and throat disorders. Local irritation in the esophagus can cause symptoms that vary from indigestion, like chest discomfort and abdominal pain, to coughing and wheezing. If the gastric acid reaches the back of the throat, it may cause a bitter taste in the mouth and/or aspiration of the gastric acid into the lungs. The acid can cause throat irritation, postnasal drip and hoarseness, as well as recurrent cough, chest congestion and lung inflammation leading to asthma and/or bronchitis/ pneumonia. This clinical review examines the potential pathophysiological mechanisms of pulmonary manifestations of GERD. It also reviews relevant clinical information concerning GERD-related chronic cough and asthma. Finally, a potential management strategy for GERD in pulmonary patients is discussed.

show abstract

Section: Pulmonary Manifestations Of Gerdmentioning

confidence: 99%

Section: Prevalencementioning

confidence: 99%

Section: Management Of Gerd In Patients With Pulmonary Manifestationsmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary manifestations of gastroesophageal reflux disease

Gaude

2009

Ann Thorac Med

108

View full text Add to dashboard Cite

show abstract

“…Certain extra-oesophageal symptoms may be associated with gastro-oesophageal reflux, leading to presentation to respiratory physicians (with cough and wheeze) and ear, nose, and throat specialists (with hoarseness and laryngitis. 1 Although often related to meals, oesophageal chest pain can also be precipitated by emotion and exercise-qualities that mimic the symptoms of angina pectoris attributable to ischaemic heart disease (IHD). Furthermore, a number of the risk factors for the development of coronary disease, such as cigarette smoking, obesity, and diabetes, also increase the likelihood of oesophageal disorders, and medical treatments of angina often have beneficial effects on oesophageal symptoms.…”

mentioning

confidence: 99%

The heart and the oesophagus: intimate relations

Heatley

Rose

Weston

2005

Postgraduate Medical Journal

View full text Add to dashboard Cite

The close anatomical relations of the heart and oesophagus, and the similarity of symptoms attributable to disorders of either organ, often lead to diagnostic difficulty in patients with chest pain. A definitive diagnosis of non-cardiac chest pain attributable to oesophageal reflux or spasm is hampered, both by the need for prolonged ambulatory monitoring of pH, manometry, and endoscopy, and by the common occurrence of asymptomatic reflux and spasm, and the corresponding difficulty in linking an episode of reflux or spasm with an episode of pain. Moreover, some patients with non-cardiac chest pain and normal tests of oesophageal structure and function have centrally mediated hypersensitivity, both within and without the oesophagus. Rather than proceed with investigations, in the absence of symptoms to suggest structural disease of the oesophagus, it would be reasonable to attempt symptomatic treatment with a proton pump inhibitor or an antidepressant.

show abstract

“…Extraesophageal manifestations of GERD have progressively attracted attention during the past decade. GERD has been associated with asthma, chronic cough, hoarseness, otitis media, atypical loss of dental enamel, idiopathic pulmonary fibrosis, recurrent pneumonia, chronic bronchitis and even sudden infant death syndrome [5][6][7][8][9]. GERD originates from a disturbance in the function of the lower esophageal sphincter (LES) including anatomical and physiological aspects [10] with regurgitation of food and acid into the esophagus.…”

Section: Introductionmentioning

confidence: 99%