Extra‐hepatic morbidity and mortality in alcohol‐related liver disease: Systematic review and meta‐analysis

Abstract

Background: Alcohol use increases the risk of many conditions in addition to liver disease; patients with alcohol-related liver disease (ALD) are therefore at risk from both extra-hepatic and hepatic disease.Aims: This review synthesises information about non-liver-related mortality in persons with ALD.Methods: A systematic literature review was performed to identify studies describing non-liver outcomes in ALD. Information about overall non-liver mortality was extracted from included studies and sub-categorised into major causes: cardiovascular disease (CVD), non-liver cancer and infection. Single-proportion meta-analysis was done to calculate incidence rates (events/1000 patient-years) and relative risks (RR) compared with control populations.

Alcohol-Related Liver Disease: Is There a Safe Alcohol Consumption Limit for Liver Disease?

“…It should be borne in mind that in addition to liver-related ill health, alcohol increases the risk of many other health conditions including cardiovascular disease and cancer which remain an issue in people with ALD. 36 There have been multiple population-based studies to examine the risk of alcohol consumption on the development of liver disease or liver-related ill health, and natural history studies in advanced liver disease. The gap in the current literature relates to individuals with early-stage liver disease and this is where the focus of investigators should be targeted.…”

“…It should be borne in mind that in addition to liver-related ill health, alcohol increases the risk of many other health conditions including cardiovascular disease and cancer which remain an issue in people with ALD. 36…”

Steatotic Liver Disease: Metabolic Dysfunction, Alcohol, or Both?

“…Similar to NAFLD, diabetes, cardiovascular disease, and obesity are highly prevalent in patients with ALD. According to a recent meta-analysis by Theodoreson et al, major causes of extrahepatic morbidity and mortality comprise cardiovascular disease, non-hepatic malignancies, as well as infection associated with increased risk of death, with a relative risk of 2.4, 2.2, and 8.2, respectively [ 32 ].…”

Alcolic liver disease: what’s new in the current decade?

“…При этом АБП остается одним из самых критических заболеваний в этой группе и влечет за собой алкогольную зависимость и злоупотребление алкоголем [6]. Коморбидность АБП наглядно демонстрируют недавно опубликованные результаты систематического обзора, в рамках которого международной группой ученых был проведен поиск исследований, описывающих непеченочные летальные исходы при АБП, и обобщена информация о смертности от внепеченочных причин пациентов с АБП [38]. Информация об общей непеченочной смертности была разделена на основные причины: сердечнососудистые заболевания (ССЗ), непеченочный рак и инфекции.…”