Extra-Intestinal Manifestations of Crohn's Disease

Rare association of polyneuropathy and Crohn’s disease: a clinicopathological study of 4 cases

“…Extra-intestinal manifestations occur in at least 25% of CD patients and they can occur prior to, in conjunction with, or subsequent to active bowel disease [1][2][3]. Multiple other organ systems can be affected, including the bones and joints, skin, eyes, hepatobiliary system, lungs, kidneys, central and peripheral nervous system.…”

“…Patients usually present with abdominal pain and diarrhoea, frequently accompanied by fever and weight loss. Extraintestinal complications of CD are common and include mainly arthritis, ocular, dermatologic manifestations and neurological abnormalities [1][2][3][4]. Peripheral neuropathy (PN) is one of the most frequent reported neurological complications in patients with CD [5][6][7][8][9][10].…”

Clinical Spectrum of Vulva Metastatic Crohn’s Disease

“…Skin manifestations of Crohn's disease, including erythema nodosum, pyoderma gangrenosum, Sweet's syndrome [9], perianal inflammation with sinus tract and fistula formation, and aphthae-like mucosal ulcers, are seen in 22-75% of patients [3]. Perianal involvement with fistula formation is the most common, accounting for 58-76% of those patients with skin involvement [10,11]. Cases affecting the genitalia are extremely uncommon [8].…”

Pulmonary involvement of inflammatory bowel disease

“…The occurence of extraintestinal manifestations (EIM) of IBD has been reported to range from 21 to 41% (2). It has been reported that patients with CD may show extraintestinal manifestations during their life in at least 25% of cases (3). These extraintestinal manifestations may involve skin (erythema nodosum, pyoderma gangrenosum), eyes (uveitis, episcleritis), liver (pericholangitis, hepatosteatosis), joints (peripheral and axial arhtropathies) and lungs (4).…”