Extra-medullary gastric and hepatic relapse of acute lymphoblastic leukaemia in an adolescent: An unusual presentation

Karthik, S.; Aw, Marion; Lin, Tan Poh

doi:10.1016/j.dld.2015.07.004

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2018

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“…Seventeen ALL cases relapsed in GI organs as late as 8 years after transplants. The pancreas was the most commonly involved site, in at least 9 cases.…”

Section: Resultsmentioning

confidence: 99%

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Leukemia in gastrointestinal organs as cause of treatment failure: 378 cases analyzed

Cunningham

Worthley

2018

American J Hematol

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Leukemia growing as tumors in gastrointestinal organs is an under-investigated cause of treatment failure and death. These present with symptoms often mistaken for common toxicities but may grow large before symptoms. To synthesize experience available only in case reports, 378 were analyzed. Invasive and metastatic behavior typical of solid GI tumors was revealed even when marrow was uninvolved. Within 3 months of diagnosis, 33% had died, 47% within 1 year. Survivals of 4 to 18 years after involvement suggest cure is possible. Evidence is presented that combined local and systemic therapy has successfully treated GI leukemic tumors when identified early.

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“…Seventeen ALL cases relapsed in GI organs as late as 8 years after transplants. The pancreas was the most commonly involved site, in at least 9 cases.…”

Section: Resultsmentioning

confidence: 99%

“…The pancreas was the most commonly involved site, in at least 9 cases. Involvement of more than one GI site was seen by regional radiology or PET scans in the majority . Only 3 had evidence of morphologic marrow relapse, one with only 10% blasts .…”

Section: Resultsmentioning

confidence: 99%

Leukemia in gastrointestinal organs as cause of treatment failure: 378 cases analyzed

Cunningham

Worthley

2018

American J Hematol

View full text Add to dashboard Cite

show abstract

Extra-medullary gastric and hepatic relapse of acute lymphoblastic leukaemia in an adolescent: An unusual presentation

Cited by 1 publication

References 1 publication

Leukemia in gastrointestinal organs as cause of treatment failure: 378 cases analyzed

Leukemia in gastrointestinal organs as cause of treatment failure: 378 cases analyzed

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