Extra-pulmonary manifestations of sarcoidosis

Vardhanabhuti, Varut; Venkatanarasimha, Nanda; Bhatnagar, Gauraang; Maviki, Mufudzi; Iyengar, Srikanth; Adams, Will; Suresh, Priya

doi:10.1016/j.crad.2011.04.018

Cited by 58 publications

(43 citation statements)

References 43 publications

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“…PET has been reported to have a high sensitivity of 100% and a specificity of 81.5-90.9%. [8] Blankstein et al ., found that the presence of focal perfusion defects and uptake on cardiac PET-CT identified patients at higher risk of death or ventricular tachycardia. These findings offer prognostic value beyond Japanese clinical criteria, the presence of extra-cardiac sarcoidosis, and left ventricular ejection fraction.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Serial PET-CT Imaging in Systemic Sarcoidosis

Carbone

Penna²,

Baughman

et al. 2014

Journal of Clinical Imaging Science

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Positron emission tomography (PET) in combination with computed tomography (PET-CT) is commonly used to identify malignant lesion in the lung. Despite there being only a few reports in literature, PET-CT imaging may have many advantages in the study of sarcoidosis, being useful in the diagnosis as well as in monitoring the response to treatment. The object of this case report is to highlight the clinical utility of integrated PET-CT imaging for evaluation of patients with systemic sarcoidosis and for comparing baseline findings to follow-up readings.

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Section: Discussionmentioning

confidence: 99%

Accuracy of Serial PET-CT Imaging in Systemic Sarcoidosis

Carbone

Penna²,

Baughman

et al. 2014

Journal of Clinical Imaging Science

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“…However, symptomatic muscular sarcoidosis is noted in only 0.5%-2.3%, and is more common in patients with extensive systemic involvement. There are three clinical subtypes of muscular sarcoidosis: acute myositic, chronic myopathic, and palpable nodular (1, 4, 5). The acute myositic type is accompanied by myalgia, fevers and elevated muscle enzymes, whereas the chronic myopathic type shows muscle atrophy and muscle weakness (6).…”

Section: Discussionmentioning

confidence: 99%

“…The manifestations vary by involved site and grade, occasionally mimicking malignancy. Isolated muscular involvement is known as common in sarcoidosis patients, but painless or impalpable cases may be undiagnosed (1, 2). We report a case of generalized muscular sarcoidosis detected only by fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/computed tomography (CT) performed during the evaluation of non-parathyroid-related hypercalcemia.…”

Section: Introductionmentioning

confidence: 99%

Muscular Sarcoidosis Detected by F-18 FDG PET/CT in a Hypercalcemic Patient

et al. 2013

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Sarcoidosis is a systemic granulomatous disease of unknown etiology that involves many organs, occasionally mimicking malignancy. We herein report a 50-yr-old woman of muscular sarcoidosis of chronic myopathic type, manifested by hypercalcemia and muscle wasting. Besides insignificant hilar lymphadenopathy, her sarcoidosis was confined to generalized atrophic muscles and therefore, F-18 FDG PET/CT alone among conventional imaging studies provided diagnostic clues for the non-parathyroid-related hypercalcemia. On follow-up PET/CT during low-dose steroid treatment, FDG uptake in the muscles disappeared whereas that in the hilar lymph nodes remained. PET/CT may be useful in the evaluation of unexpected disease extent and monitoring treatment response in suspected or known sarcoidosis patients.

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“…Recent studies have demonstrated an emerging role for whole-body FDG-PET CT in investigating sarcoidosis 10 11. PET scanning can detect occult or extrapulmonary disease and may help to determine an accessible site for biopsy 1.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis as a cause of unappreciated hypercalcaemia in a patient with end-stage renal disease on peritoneal dialysis

et al. 2013

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The differential diagnosis of hypercalcaemia in patients with end-stage renal disease undergoing dialysis should be considered for causes related or unrelated to renal failure itself or therapies for renal failure. In particular, peritoneal dialysis may hinder awareness of a clinical problem due to its own peculiarities and effects on homeostasis of the body, thus creating misconceptions in interpreting laboratory data and diagnosing a disease. We describe here a case of systemic sarcoidosis which was delayed due to failure to recognise underestimated hypercalcaemia in a patient undergoing peritoneal dialysis. Clinicians need to remain aware of the change of minerals that may arise from peritoneal dialysis and should perform an extensive investigation for the cause of hypercalcaemia.

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Extra-pulmonary manifestations of sarcoidosis

Cited by 58 publications

References 43 publications

Accuracy of Serial PET-CT Imaging in Systemic Sarcoidosis

Accuracy of Serial PET-CT Imaging in Systemic Sarcoidosis

Muscular Sarcoidosis Detected by F-18 FDG PET/CT in a Hypercalcemic Patient

Sarcoidosis as a cause of unappreciated hypercalcaemia in a patient with end-stage renal disease on peritoneal dialysis

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