Extra-rectal lymphogranuloma venereum in France: a clinical and molecular study

Desclaux, A.; Touati, Arabella; Néau, Didier; Laurier-Nadalié, Cécile; Bebear, Cécile; Barbeyrac, Bertille de; Cazanave, Charles

doi:10.1136/sextrans-2017-053126

Cited by 15 publications

(11 citation statements)

References 25 publications

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“…Lymphogranuloma venereum (LGV) is endemic among European men who have sex with men (MSM) since 2003 . It is a relatively common cause of proctitis, but rarely causes genital or oro‐pharyngeal infections . Although other strains like serovar/genovar L2 have been identified, subvariant L2b is the causative strain in the majority of cases in Europe, and a high degree of clonal relatedness has been found with genome sequencing techniques .…”

Section: Epidemiologymentioning

confidence: 99%

2019 European guideline on the management of lymphogranuloma venereum

Vries

Barbeyrac

Vrieze

et al. 2019

Acad Dermatol Venereol

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Section: Epidemiologymentioning

confidence: 99%

2019 European guideline on the management of lymphogranuloma venereum

Vries

Barbeyrac

Vrieze

et al. 2019

Acad Dermatol Venereol

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“…The last case was published in a retrospective revision of 56 cases of extrarectal LGV. One of six patients with pharyngeal infection showed an ulcer on the tongue and a cervical lymphadenopathy 7. He was diagnosed by NAAT and presumably treated with doxycycline for 21 days (data not specified).…”

Section: Discussionmentioning

confidence: 99%

Lymphogranuloma venereum presenting as an ulcer on the tongue

Riera‐Monroig

Vega

2018

Sex Transm Infect

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Oropharyngeal lymphogranuloma venereum (LGV) is an uncommon presentation and mainly consists of either asymptomatic infections or enlarged cervical lymphadenopathy. According to cross-sectional studies, the prevalence of pharyngeal LGV among men who have sex with men (MSM) seems to be very low. Tissue tropism could explain the difference between rectal and oral mucosa infection frequencies. This paper reports the singular case of an oral ulcer caused by LGV in an MSM who had also an asymptomatic rectal infection. Given the increasing number of cases of LGV, unusual presentations such as oral ulceration may be seen more frequently.

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“…In most cases, the diagnosis of LGV genital lesions is made late after the onset of symptoms, due to lack of suspicion. 3 Recent European case series showed that, in contrast to proctitis, 50% or less of patients with LGV genital ulcers were HIV-positive. 3 The differential diagnosis of a genital ulcer should include syphilis, herpes virus, chancroid,…”

Section: Casementioning

confidence: 99%

“…2 However, most HE cases are aetiologically categorized as irritant contact dermatitis (ICD), 10-20% as allergic contact dermatitis (ACD) and very few as protein contact dermatitis (PCD). [3][4][5] Individuals with AD are thought to have an increased risk of ICD, as explained by reduced threshold to irritants.…”

Section: Casementioning

confidence: 99%

Primary genital lymphogranuloma venereum in the HIV pre‐exposure prophylaxis era

Arandes-Marcocci

Collgros

Serra-Pladevall

et al. 2020

Acad Dermatol Venereol

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Primary genital lymphogranuloma venereum in the HIV pre-exposure prophylaxis era Editor Lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis (CT) serovars L1-L3. 1 In Europe, it is endemic among men who have sex with men (MSM) causing proctitis, mainly co-infected with HIV, since 2003. 2 Its presentation as a genital lesion has been rarely described and accounts for around 5% of cases in the United Kingdom and France. 3,4 Increasing STIs rates in MSM have been reported during the last decade in several Western countries, 5 and it is plausible that HIV pre-exposure prophylaxis (PrEP) might contribute to maintaining this trend. 6 We report 2 cases with genital primary LGV mimicking primary syphilis seen at in our clinic in Barcelona. Case 1. A 43-year-old HIV-negative man on PrEP presented with a one-week history of a painful penile ulcer. He reported unprotected anal sex with three men in previous month. Clinically, there was a red ulcer on the dorsal side of the penis with an inguinal adenopathy on the left groin (Fig. 1). Because of a negative dark-field examination and the large size of the adenopathy, we initiated empirical treatment with doxycycline 100 mg orally twice daily. Swabs from the penile ulcer were collected for bacterial culture and multiplex PCR testing. Only CT was detected. The patient was instructed to continue up to 3 weeks of treatment. Three weeks after treatment, the penile ulcer and the inguinal mass almost disappeared.

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Extra-rectal lymphogranuloma venereum in France: a clinical and molecular study

Abstract: In the span of 6 years, 56 extrarectal LGV cases were confirmed through genotyping in France. Extrarectal LGV seemed to share a common epidemiological background with rectal disease in terms of affected population and genovar distribution. HIV prevalence was lower than expected.

Cited by 15 publications

References 25 publications

2019 European guideline on the management of lymphogranuloma venereum

2019 European guideline on the management of lymphogranuloma venereum

Lymphogranuloma venereum presenting as an ulcer on the tongue

Primary genital lymphogranuloma venereum in the HIV pre‐exposure prophylaxis era

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