Extra Virgin Olive Oil and Cardiovascular Protection in Chronic Kidney Disease

Marrone, Giulia; Urciuoli, Silvia; Lauro, Manuela Di; Ruzzolini, Jessica; Ieri, Francesca; Vignolini, Pamela; Daniele, Francesca Di; Guerriero, Cristina; Nediani, Chiara; Daniele, Nicola Di; Noce, Annalisa

doi:10.3390/nu14204265

Cited by 15 publications

(12 citation statements)

References 76 publications

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“…Chronic kidney failure refers to a process of significant, continuous, and irreversible decline in the number of nephrons, in which the kidney's ability to eliminate metabolic wastes and retain fluids and electrolytes is lost. This failure leads to the syndrome of increased blood urea (2). According to the avail-able data, chronic kidney failure affects more than 10% of the general population worldwide, accounting for more than 800 million people (3).…”

Section: Introductionmentioning

confidence: 99%

Effect of mHealth Training on Treatment Adherence in Hemodialysis Patients

et al. 2023

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Background: Technological advancements and ease of communicating with and educating patients with kidney failure using various technologies have facilitated the achievement of treatment goals. Objectives: The present study aimed to examine the effect of mHealth training on treatment adherence in hemodialysis patients in Zahedan. Methods: This quasi-experimental study was conducted on 80 hemodialysis patients admitted to teaching hospitals in Zahedan in 2022. The participants were selected using convenience sampling and were divided into two intervention and control groups by allocation with permutation blocks. In addition to routine training, the participants in the intervention group received mHealth training in five areas of treatment adherence using a smartphone application (My Dialysis) developed by the researcher. The participants in the control group received only routine training. The data were collected by a demographic information form, the Media Literacy Questionnaire, and the End-Stage Renal Disease Adherence Questionnaire (ESRD-AQ) in both groups before and three months after the intervention. The collected data were analyzed with SPSS (version 26) using the paired and independent samples t-test, chi-square test, and analysis of covariance (ANCOVA) at the significance level of less than 0.05 (P < 0.05). Results: The mean treatment adherence score for the patients in the control group increased from 1011.87 ± 150.96 before the intervention to 1110.62 ± 86.95 after the intervention, showing a significant increase (P < 0.001). Besides, the mean treatment adherence score for the patients in the intervention group increased significantly from 1067.50 ± 122.24 before the intervention to 1161.25 ± 49.98 after the intervention (P > 0.001). The results of ANCOVA to control for the significant effect of the pretest scores and the disease duration showed that the patients' mean treatment adherence scores in the two groups significantly differed after the intervention (P < 0.05). Conclusions: This study confirmed the significant positive effects of mHealth training on the treatment adherence of dialysis patients. Thus, considering the effectiveness of routine training, mHealth training can be used with routine training in treatment programs for hemodialysis patients to improve their treatment adherence.

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Section: Introductionmentioning

confidence: 99%

Effect of mHealth Training on Treatment Adherence in Hemodialysis Patients

et al. 2023

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“…The potential cardioprotective benefits of OO consumption have been demonstrated in several studies and are summarized in Table 2 [ 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 ].…”

Section: Resultsmentioning

confidence: 99%

Is There More to Olive Oil than Healthy Lipids?

Isaakidis,

Maghariki,

Carvalho-Barros

et al. 2023

Nutrients

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The Mediterranean diet is a healthy dietary pattern whose main characteristic is olive oil consumption. The potential health benefits of olive oil have been extensively investigated and the present review provides the more recent clinical evidence supporting the positive impact of olive oil intake on human health. PubMed (n = 227) and Scopus (n = 308) databases were searched for published clinical studies in English over the past six years (October 2016 to December 2022), following key word searches of “olive oil” and “health”. Major findings associated olive oil with antioxidant and anti-inflammatory effects, improvement in endothelial function and lipid profile, prevention of obesity, diabetes, cardiovascular and neurodegenerative diseases, and modulation of the gut microbiota. These benefits are attributed to the nutritional composition of olive oil, which has a high content of monounsaturated fatty acids (MUFA) (oleic acid in particular) and minor compounds such as polyphenols (oleuropein and hydroxytyrosol). Although additional research continues to be required, the more recently generated evidence supports the potential of olive oil to contribute beneficially to health and to the prevention and management of a variety of non-communicable diseases, as a consequence of the synergism between its components’ complexity.

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“…However, when it comes to CKD and CAD, physical activity recommendations should be carefully considered, depending on the patient’s condition, due to the potential risk of impairing kidney function and increasing proteinuria, or triggering cardiovascular events during exercise [ 48 , 49 ]. As for olive oil in the diet, some evidence has suggested that this intervention may have a beneficial impact in preventing cardiovascular or kidney events [ 50 , 51 ]. Specifically, our observations have revealed that the impact of lifestyle intervention seems to have an individual pattern, with a positive impact in the patients at both low and high risk.…”

Section: Discussionmentioning

confidence: 99%

Prognosis and Personalized In Silico Prediction of Treatment Efficacy in Cardiovascular and Chronic Kidney Disease: A Proof-of-Concept Study

Jaimes Campos,

Andújar,

Keller

et al. 2023

Pharmaceuticals

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(1) Background: Kidney and cardiovascular diseases are responsible for a large fraction of population morbidity and mortality. Early, targeted, personalized intervention represents the ideal approach to cope with this challenge. Proteomic/peptidomic changes are largely responsible for the onset and progression of these diseases and should hold information about the optimal means of treatment and prevention. (2) Methods: We investigated the prediction of renal or cardiovascular events using previously defined urinary peptidomic classifiers CKD273, HF2, and CAD160 in a cohort of 5585 subjects, in a retrospective study. (3) Results: We have demonstrated a highly significant prediction of events, with an HR of 2.59, 1.71, and 4.12 for HF, CAD, and CKD, respectively. We applied in silico treatment, implementing on each patient’s urinary profile changes to the classifiers corresponding to exactly defined peptide abundance changes, following commonly used interventions (MRA, SGLT2i, DPP4i, ARB, GLP1RA, olive oil, and exercise), as defined in previous studies. Applying the proteomic classifiers after the in silico treatment indicated the individual benefits of specific interventions on a personalized level. (4) Conclusions: The in silico evaluation may provide information on the future impact of specific drugs and interventions on endpoints, opening the door to a precision-based medicine approach. An investigation into the extent of the benefit of this approach in a prospective clinical trial is warranted.

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Extra Virgin Olive Oil and Cardiovascular Protection in Chronic Kidney Disease

Cited by 15 publications

References 76 publications

Effect of mHealth Training on Treatment Adherence in Hemodialysis Patients

Effect of mHealth Training on Treatment Adherence in Hemodialysis Patients

Is There More to Olive Oil than Healthy Lipids?

Prognosis and Personalized In Silico Prediction of Treatment Efficacy in Cardiovascular and Chronic Kidney Disease: A Proof-of-Concept Study

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