Extracapsular spread

Myers, Jeffrey N.; Greenberg, Jayson S.; Mo, Vivian; Roberts, Dianna B.

doi:10.1002/1097-0142(20011215)92:12<3030::aid-cncr10148>3.0.co;2-p

Cited by 301 publications

(56 citation statements)

References 13 publications

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“…Despite the overall improved prognosis of HPV-positive SCCOP relative to HPV-negative SCCOP, we found no significant difference in incidence of extracapsular spread of nodal metastases, a well-established predictor of poor prognosis in squamous cell carcinoma of the head and neck. 18–21 Our data are consistent with the findings of Goldenberg et al, 13 which demonstrated increased incidence of cystic nodal metastases in HPV-positive SCCOP. These imaging differences between HPV-positive SCCOP compared with HPV-negative SCCOP are congruent with an understanding that HPV-positive SCCOP represent a separate clinical entity, driven by different somatic molecular events and with a different clinical phenotype.…”

Section: Discussionsupporting

confidence: 92%

Differences in Imaging Characteristics of HPV-Positive and HPV-Negative Oropharyngeal Cancers: A Blinded Matched-Pair Analysis

Cantrell

Peck

et al. 2013

AJNR Am J Neuroradiol

134

119

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BACKGROUND AND PURPOSE Human papillomavirus–positive oropharyngeal cancers typically have younger age of onset, limited tobacco exposure, and more favorable prognosis than HPV-negative oropharyngeal cancers. We assessed whether HPV-positive and HPV-negative oropharyngeal cancers have consistent differences in pretreatment imaging characteristics. MATERIALS AND METHODS A retrospective review of 136 pretreatment CT examinations of paired HPV-positive and HPV-negative oropharyngeal cancers matched for T stage, tumor subsite, and smoking status was performed with the reviewing radiologist blinded to HPV status and clinical stage. Demographic/clinical characteristics and imaging characteristics of primary lesions and metastatic nodal disease were compared by use of Fisher exact testing. The McNemar χ2 test was used for the matched-pair analysis. RESULTS By imaging, HPV-negative tumors were more likely to demonstrate invasion of adjacent muscle (26% versus 6%, P = .013). HPV-positive primary tumors were more likely to be enhancing and exophytic with well-defined borders, whereas HPV-negative primary tumors were more likely to be isoattenuated and demonstrate ill-defined borders, though these results were not statistically significant. HPV-positive tumors were more likely to demonstrate cystic nodal metastases than HPV-negative tumors (36% versus 9%, P = .002). CONCLUSIONS In this matched and blinded analysis of the imaging differences between HPV-positive and HPV-negative oropharyngeal cancers, HPV-positive carcinomas often had primary lesions with well-defined borders and cystic nodal metastases, whereas HPV-negative primaries more often had poorly defined borders and invasion of adjacent muscle.

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Section: Discussionsupporting

confidence: 92%

Differences in Imaging Characteristics of HPV-Positive and HPV-Negative Oropharyngeal Cancers: A Blinded Matched-Pair Analysis

Cantrell

Peck

et al. 2013

AJNR Am J Neuroradiol

134

119

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“…In HNSCC, the most significant histologic prognostic factor for overall survival remains the presence of a positive lymph node metastasis followed by the presence of extracapsular extension (ECE) of tumor outside of a lymph node 62, 63 . While the majority of the data is from oral SCC, the presence of ECE is now widely recognized as an adverse feature, including in other tumor types, which warrants consideration for intensified treatment regiments 64 .…”

Section: Histopathology Prognosticators In Sccmentioning

confidence: 99%

Epidemiologic Trends in Head and Neck Cancer and Aids in Diagnosis

Vigneswaran¹,

Williams²

2014

Oral and Maxillofacial Surgery Clinics of North America

688

496

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“…Morbidity associated with the disease further affects the quality of life in patients as nutrition, speech and general immunity gets compromised as well. In oral cancer patients, death usually occurs as a result of local invasion into the stromal tissue of head & neck and cervical lymph node metastases [6,7]. …”

Section: Introductionmentioning

confidence: 99%

A role for aberrantly expressed nuclear localized decorin in migration and invasion of dysplastic and malignant oral epithelial cells

Dil

Banerjee

2011

Head Neck Oncol

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BackgroundOral cancer is the sixth most common malignancy worldwide with a mortality rate that is higher than many other cancers. Death usually occurs as a result of local invasion and regional lymph node metastases. Decorin is a multifunctional proteoglycan of the extracellular matrix that affects the biology of various types of cancer. Previously; we have shown that decorin is aberrantly expressed in the nucleus in human dysplastic oral keratinocytes (DOK) and malignant squamous cells carcinoma (SCC-25) and human biopsy tissues. In this study, we examined the role of nuclear decorin in oral cancer progression.Materials and methodsWe have used a post-transcriptional gene silencing (RNA interference) approach to stably knockdown nuclear decorin gene expression in DOK and SCC-25 cells using a specific shRNA plasmid and a combination of immunological and molecular techniques to study nuclear decorin function in these oral epithelial cell lines.ResultsMore than 80% decorin silencing/knockdown was achieved as confirmed by real time PCR and western blot analysis in both DOK and SCC-25 cells. This RNA interference-mediated knockdown of nuclear decorin expression resulted in significantly reduced invasion and migration in these cell lines as measured by Matrigel™ coated and uncoated Trans well chamber assays respectively. Decorin silencing also resulted in reduced IL-8 mRNA and proteins levels in these cell lines. Culturing decorin silenced DOK and SCC-25 cells, with recombinant human IL-8 or IL-8 containing conditioned medium from respective un-transfected cells for 24 h prior to migration and invasion experiments, resulted in the salvation of reduced migration and invasion phenotype. Furthermore, we found that nuclear localized decorin interacts with EGFR in the nuclear fractions of both DOK and SCC-25 cells. Interestingly, EGFR (trans) activation has previously been shown to be involved in IL-8 production in various epithelia.ConclusionsTaken together, our results indicate that nuclear localized decorin plays an important role in migration and invasion of oral cancer cells and thus may present as a novel potential target for the treatment of oral cancer.

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Extracapsular spread

Cited by 301 publications

References 13 publications

Differences in Imaging Characteristics of HPV-Positive and HPV-Negative Oropharyngeal Cancers: A Blinded Matched-Pair Analysis

Differences in Imaging Characteristics of HPV-Positive and HPV-Negative Oropharyngeal Cancers: A Blinded Matched-Pair Analysis

Epidemiologic Trends in Head and Neck Cancer and Aids in Diagnosis

A role for aberrantly expressed nuclear localized decorin in migration and invasion of dysplastic and malignant oral epithelial cells

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