2024
DOI: 10.1002/iub.2905
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Extracellular adenosine oppositely regulates the purinome machinery in glioblastoma and mesenchymal stem cells

Deborah Pietrobono,
Lara Russo,
Maria Sofia Bertilacchi
et al.

Abstract: Glioblastoma (GB) is a lethal brain tumor that rapidly adapts to the dynamic changes of the tumor microenvironment (TME). Mesenchymal stem/stromal cells (MSCs) are one of the stromal components of the TME playing multiple roles in tumor progression. GB progression is prompted by the immunosuppressive microenvironment characterized by high concentrations of the nucleoside adenosine (ADO). ADO acts as a signaling molecule through adenosine receptors (ARs) but also as a genetic and metabolic regulator. Herein, th… Show more

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