Extracellular ATP contributes to the reactive oxygen species burst and exaggerated mitochondrial damage in D-galactosamine and lipopolysaccharide-induced fulminant hepatitis

Xu, Rong; Yuan, Li-sha; Gan, Ying-qing; Lu, Na; Li, Ya-ping; Zhou, Zhi-ya; Hu, Bo; Wong, Tak-sui; He, Xian-hui; Zha, Qing-bing; Ouyang, Dong-yun

doi:10.1016/j.intimp.2024.111680

International Immunopharmacology

2024

DOI: 10.1016/j.intimp.2024.111680

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Extracellular ATP contributes to the reactive oxygen species burst and exaggerated mitochondrial damage in D-galactosamine and lipopolysaccharide-induced fulminant hepatitis

Rong Xu,

Li-sha Yuan,

Ying-qing Gan

et al.

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Cited by 3 publications

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Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine

Dong,

Lin,

et al. 2024

Clinical Chemistry and Laboratory Medicine (CCLM)

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Extracellular vesicles (EVs) represent a diverse class of nanoscale membrane vesicles actively released by cells. These EVs can be further subdivided into categories like exosomes and microvesicles, based on their origins, sizes, and physical attributes. Significantly, disease-derived EVs have been detected in virtually all types of body fluids, providing a comprehensive molecular profile of their cellular origins. As a result, EVs are emerging as a valuable addition to liquid biopsy techniques. In this collective statement, the authors share their current perspectives on EV-related research and product development, with a shared commitment to translating this newfound knowledge into clinical applications for cancer and other diseases, particularly as disease biomarkers. The consensus within this document revolves around the overarching recognition of the merits, unresolved questions, and existing challenges surrounding EVs. This consensus manuscript is a collaborative effort led by the Committee of Exosomes, Society of Tumor Markers, Chinese anti-Cancer Association, aimed at expediting the cultivation of robust scientific and clinically applicable breakthroughs and propelling the field forward with greater swiftness and efficacy.

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Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine

Dong,

Lin,

et al. 2024

Clinical Chemistry and Laboratory Medicine (CCLM)

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The role of extracellular ATP in regulating the functional activity of cells

Patrakeeva

2024

Sibirskij nauchnyj medicinskij zhurnal

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A search and analysis of scientific articles presented in the databases PubMed, ScienceDirect, Elsevier, eLibrary for 2000–2024 was carried out. The selection criterion was the presence in the articles of information on the concentration of extracellular ATP in normal and pathological tissues, the mechanisms of purinergic regulation of cell functioning, and the expression of CD73 and CD39 ectonucleotidases on cells, which regulate proinflammatory extracellular ATP catabolism to immunosuppressive adenosine. Modern data are presented on the role of extracellular ATP in the regulation of cell functioning under normal and pathological conditions, during inflammation and the formation of cellular and humoral immune responses, as well as on the study of the mechanisms of purinergic signaling from extracellular ATP in the development of targeted drugs for various diseases, including neoplasms, neurodegenerative and autoimmune pathologies.

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The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections

Kombe Kombe,

Fotoohabadi,

Nanduri

et al. 2024

IJMS

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Respiratory viruses constitute a significant cause of illness and death worldwide. Respiratory virus-associated injuries include oxidative stress, ferroptosis, inflammation, pyroptosis, apoptosis, fibrosis, autoimmunity, and vascular injury. Several studies have demonstrated the involvement of the nuclear factor erythroid 2-related factor 2 (Nrf2) in the pathophysiology of viral infection and associated complications. It has thus emerged as a pivotal player in cellular defense mechanisms against such damage. Here, we discuss the impact of Nrf2 activation on airway injuries induced by respiratory viruses, including viruses, coronaviruses, rhinoviruses, and respiratory syncytial viruses. The inhibition or deregulation of Nrf2 pathway activation induces airway tissue damage in the presence of viral respiratory infections. In contrast, Nrf2 pathway activation demonstrates protection against tissue and organ injuries. Clinical trials involving Nrf2 agonists are needed to define the effect of Nrf2 therapeutics on airway tissues and organs damaged by viral respiratory infections.

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Extracellular ATP contributes to the reactive oxygen species burst and exaggerated mitochondrial damage in D-galactosamine and lipopolysaccharide-induced fulminant hepatitis

Cited by 3 publications

References 47 publications

Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine

Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine

The role of extracellular ATP in regulating the functional activity of cells

The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections

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