Extracellular ATP Promotes Systemic Inflammation During Acute Pancreatitis

Dixit, Ajay Kumar; George, John E.; Cheema, Hassam; Ryu, Yungil; Dudeja, Vikas; Dawra, Rajinder; Saluja, Ashok

doi:10.1016/s0016-5085(17)33061-5

Cited by 2 publications

(5 citation statements)

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“…While assessing the carcinoma tissue samples, the average expression values of P2X4 and P2X7 increased vigorously, this aligns with the recent evidence to strengthen the theory of P2X4 and P2X7 receptors' association with incessant inflammation. A relatively gradual increase in their expression with the development of disease has been found substantial in multiple cancer types [14,25,28,29]. The P2X4 and P2X7 receptors' expression for a specific cancer type in the studied carcinomas was relatively equal with a nominal difference which is affirmed by a recent evidence of P2X4 and P2X7 receptors' co-expression in the form of hetero-trimers on the cell surface [30][31][32].…”

Section: Comparative Analysis Of P2x4 and P2x7 In Hepatocellular Carcsupporting

confidence: 56%

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Role of purinergic receptors in hepatobiliary carcinoma in Pakistani population: an approach towards proinflammatory role of P2X4 and P2X7 receptors

Asif

Khalid

Manzoor

et al. 2019

Purinergic Signalling

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The primary malignancy of liver, known as hepatocellular carcinoma (HCC), comprises 9% of all hepatobiliary carcinomas. A steady rise has also been observed in adenocarcinoma (ADC) of the liver and ampullary carcinoma (AMC), ascending to 0.5% of gastrointestinal malignancies. Hepatobiliary carcinomas consist of 13% of all cancer occurrences worldwide. Purinergic receptor-based signaling holds the therapeutic potential based on its role in cell proliferation of several carcinomas. An altered ATP concentration in nanomoles may lead towards crucial changes in cancer growth patterns in liver tissue. A total of 40 tissue samples were collected (20 samples of HCC, 10 samples of ADC, and 10 samples of AMC) from patients that underwent surgery. P2X4 and P2X7 receptors exhibited significantly increased expression in HCC, ADC, and AMC samples as compared with the control tissue samples. While ADC and AMC samples showed higher expression of P2X4 and P2X7 than the control, statistically, HCC samples exhibited the most significant expression of both P2X4 and P2X7 receptors than control tissues. It may be inferred that higher expression of P2X4 and P2X7 receptors is significantly associated with the upregulated cellular stress leading to inflammation and it is plausible that both these receptors may be used in diagnostic, prognostic, and therapeutic tools for carcinoma studies in the future.

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Section: Comparative Analysis Of P2x4 and P2x7 In Hepatocellular Carcsupporting

confidence: 56%

“…Recently, purinergic signaling has emerged as an essential signaling mechanism to regulate inflammation [14]. Two key receptors in purinergic signaling are P2X4 and P2X7.…”

Section: Introductionmentioning

confidence: 99%

Role of purinergic receptors in hepatobiliary carcinoma in Pakistani population: an approach towards proinflammatory role of P2X4 and P2X7 receptors

Asif

Khalid

Manzoor

et al. 2019

Purinergic Signalling

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“…Given that ATP mainly kept in reserve at acinar cells with high concentration, the elevating extracellular concentration of ATP is thought to attribute to the release of injured cells (Yegutkin et al, 2006). Necrotic Acinar cells undergoing cytoplasmic membrane destruction are likely to be the main source of extracellular ATP (eATP) (Dixit et al, 2019b). Other sources of high eATP levels may include activated immune cells, duct cells, endothelial cells, or even cells undergoing apoptosis (Bodin and Burnstock, 1996;Elliott et al, 2009;Junger, 2011;Kowal et al, 2015).…”

Section: Atp and Apmentioning

confidence: 99%

“…Hence, this interaction enhances cell damage. Nevertheless, there still could be an abundant amount of ATP, which, if released, can play an essential role as DAMPs by activating purinergic signaling (Dixit et al, 2019b).…”

Section: Atp and Apmentioning

confidence: 99%

“…eATP has been shown to be involved in guiding neutrophils to the site of injury, activating T cells, platelets, mast cells and monocytes, promoting inflammasome activation in macrophages, and releasing cytokine (Cekic and Linden, 2016). One study has shown that the release of eATP promotes systemic injury in severe acute pancreatitis (Dixit et al, 2019b). With the increasing concentration of eATP, purinergic signaling is triggered by nucleotides' interaction in P2 receptors, such as transcell membrane cationic channels (P2XR) and G-protein coupled receptors (P2YR), thereby initiating autocrine/paracrine signaling, (Beavis et al, 2012;Zimmermann et al, 2012).…”

Section: Atp and Apmentioning

confidence: 99%

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Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis

Zhou

Jin

Pan

et al. 2022

Front. Cell. Infect. Microbiol.

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Previous researches have emphasized a trypsin-centered theory of acute pancreatitis (AP) for more than a century. With additional studies into the pathogenesis of AP, new mechanisms have been explored. Among them, the role of immune response bears great importance. Pro-inflammatory substances, especially damage-associated molecular patterns (DAMPs), play an essential role in activating, signaling, and steering inflammation. Meanwhile, activated neutrophils attach great importance to the immune defense by forming neutrophil extracellular traps (NETs), which cause ductal obstruction, premature trypsinogen activation, and modulate inflammation. In this review, we discuss the latest advances in understanding the pathological role of DAMPs and NETs in AP and shed light on the flexible crosstalk between these vital inflammatory mediators. We, then highlight the potentially promising treatment for AP targeting DAMPs and NETs, with a focus on novel insights into the mechanism, diagnosis, and management of AP.

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Extracellular ATP Promotes Systemic Inflammation During Acute Pancreatitis

Cited by 2 publications

References 0 publications

Role of purinergic receptors in hepatobiliary carcinoma in Pakistani population: an approach towards proinflammatory role of P2X4 and P2X7 receptors

Role of purinergic receptors in hepatobiliary carcinoma in Pakistani population: an approach towards proinflammatory role of P2X4 and P2X7 receptors

Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis

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