Extracellular derivatives for bone metabolism

Wu, Yan; Song, Peiran; Wang, Miaomiao; Liu, Han; Jing, Yingying; Su, Jiacan

doi:10.1016/j.jare.2024.01.011

Journal of Advanced Research

2024

DOI: 10.1016/j.jare.2024.01.011

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Extracellular derivatives for bone metabolism

Yan Wu,

Peiran Song,

Miaomiao Wang

et al.

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2024

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Cited by 7 publications

References 171 publications

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Extracellular Vesicles in Gut‐Bone Axis: Novel Insights and Therapeutic Opportunities for Osteoporosis

Liu,

Li,

Yang

et al. 2024

Small Science

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Osteoporosis (OP) is a systemic and retrogressive disease characterized by decreased bone density and fragile bone microstructure. Extracellular vesicles (EVs), a cell‐free system with a phospholipid bilayer released by cells that cannot be replicated, have unique nanostructure, stable drug‐loading capacity, and good biocompatibility, playing an important role in regulating the gut‐skeletal axis. A growing body of research demonstrates that gut microbiota (GM) influence the development of OS, while bacteria‐derived EVs (BEVs) have become a new dialogue medium between the gut and bone. Additionally, organoids are 3D cell clusters in vitro that highly simulate the structure and function of corresponding organs. Intestinal organoids‐derived EVs (IOEVs) serve as another promising communication medium between the gut and bone due to their significant physiological effects. Herein, three types of gut‐bone axes, including the traditional, BEVs‐based, and IOEVs‐based gut‐bone axes are innovatively proposed. The impact of the BEVs‐based and IOEVs‐based gut‐bone axes on OP is focused. The comprehensive summary of three types of gut‐bone axes will reveal the relationship between intestinal and bone and provide new solution to OP therapy.

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Extracellular Vesicles in Gut‐Bone Axis: Novel Insights and Therapeutic Opportunities for Osteoporosis

Liu,

Li,

Yang

et al. 2024

Small Science

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Bridging relevance between microplastics, human health and bone metabolism: Emerging threats and research directions

Zhang,

Zhou,

Wang

et al. 2024

Environmental Chemistry and Ecotoxicology

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A review of the current status and future prospects of the bone remodeling process: Biological and mathematical perspectives

Bahrami,

Khonakdar,

Moghaddam

et al. 2024

Progress in Biophysics and Molecular Biology

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Extracellular derivatives for bone metabolism

Cited by 7 publications

References 171 publications

Extracellular Vesicles in Gut‐Bone Axis: Novel Insights and Therapeutic Opportunities for Osteoporosis

Extracellular Vesicles in Gut‐Bone Axis: Novel Insights and Therapeutic Opportunities for Osteoporosis

Bridging relevance between microplastics, human health and bone metabolism: Emerging threats and research directions

A review of the current status and future prospects of the bone remodeling process: Biological and mathematical perspectives

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