Extracellular Hepatitis C Virus Core Protein Activates STAT3 in Human Monocytes/Macrophages/Dendritic Cells via an IL-6 Autocrine Pathway

Tacke, Robert; Tosello-Trampont, Annie; Nguyen, Virginia; Mullins, David W.; Hahn, Young S.

doi:10.1074/jbc.m110.217653

Cited by 87 publications

(91 citation statements)

References 44 publications

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“…Similarly, HCV core protein was able to induce generation of MDSCs from PBMCs by activating STAT3 and the PI3K pathway (118,148,149). During HCV infection, expression of several miRNAs was altered in CD33 + myeloid cells, including miR-124, which was downregulated, in part, due to HCV-induced overexpression of STAT-3 (127).…”

Section: Factors Involved In Mdsc Expansionmentioning

confidence: 96%

The Role of Myeloid-Derived Suppressor Cells in Viral Infection

2017

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Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells that are well described as potent immune regulatory cells during human cancer and murine tumor models. Reports of MDSCs during viral infections remain limited, and their association with immunomodulation of viral diseases is still being defined. Here, we provide an overview of MDSCs or MDSC-like cells identified during viral infections, including murine viral models and human viral diseases. Understanding the similarities and/or differences of virally induced versus tumor-derived MDSCs will be important for designing future immunotherapeutic approaches.

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Section: Factors Involved In Mdsc Expansionmentioning

confidence: 96%

The Role of Myeloid-Derived Suppressor Cells in Viral Infection

2017

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“…In addition, numerous carcinogens (e.g. nicotine in cigarette smoke [34], diesel exhaust particles [72], hepatitis C virus core protein [73], lipopolysaccharide (LPS) [74]), environmental stress (e.g., ultraviolet light [75], osmotic shock [76], heat shock [77] and oxidative stress [78]) and other factors such as EBV oncoprotein LMP1 [79], HIV-1 Nef protein [80], leptin [81], Ca 2 + /calmodulin-dependent protein kinase IIγ (CaMKIIγ) [82], bile acids and low pH [83], black soy peptides [84], diazoxide [85], isoliquiritigenin [86], and olanzapine [87] have been identified to activate STAT3 (Fig. 1).…”

Section: Stat3 Activation By Diverse Agentsmentioning

confidence: 99%

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors

Siveen

Sikka

Surana

et al. 2014

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

481

510

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Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic transcription factors that mediate intracellular signaling that is usually generated at cell surface receptors and thereby transmit it to the nucleus. Numerous studies have demonstrated constitutive activation of STAT3 in a wide variety of human tumors, including hematological malignancies (leukemias, lymphomas, and multiple myeloma) as well as diverse solid tumors (such as head and neck, breast, lung, gastric, hepatocellular, colorectal and prostate cancers). There is strong evidence to suggest that aberrant STAT3 signaling promotes initiation and progression of human cancers by either inhibiting apoptosis or inducing cell proliferation, angiogenesis, invasion, and metastasis. Suppression of STAT3 activation results in the induction of apoptosis in tumor cells, and accordingly its pharmacological modulation by tyrosine kinase inhibitors, antisense oligonucleotides, decoy nucleotides, dominant negative proteins, RNA interference and chemopreventive agents have been employed to suppress the proliferation of various human cancer cells in culture and tumorigenicity in vivo. However, the identification and development of novel drugs that can target deregulated STAT3 activation effectively remains an important scientific and clinical challenge. This review presents the evidence for critical roles of STAT3 in oncogenesis and discusses the potential for development of novel cancer therapies based on mechanistic understanding of STAT3 signaling cascade.

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“…DCs exposed to the extracellular HCV core prevent the generation of CD4 + T helper (Th) 1 responses (Waggoner et al 2007 ). Modulation of immune cell function by the HCV extracellular core involves the activation of signal transducer and activator of transcription 3 (STAT3) in monocytes, macrophages, and DCs (Tacke et al 2011 ).…”

Section: Hepatitis C Virus Infection Triggers Liver Infl Ammationmentioning

confidence: 99%

Hepatitis C Virus (HCV)-Induced Inflammation: The Role of Cross-Talk Between HCV-Infected Hepatocytes and Stellate Cells

Nishitsuji

Funami

Shimizu

et al. 2015

Inflammation and Immunity in Cancer

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Hepatitis C virus (HCV) is a major public health problem, as 170 million people worldwide are currently chronically infected with the virus. HCV infection leads to chronic infl ammation, which is the initial step toward fi brosis and is a signifi cant risk factor for developing hepatocellular carcinoma. HCV-induced liver infl ammation involves several events, such as modifi cation of cytokine and chemokine pathways, oxidative stress, and induction of steatosis. Recent studies have revealed that not only HCV-infected hepatocytes but also neighboring cells, such as lymphocytes, Kupffer cells and hepatic stellate cells (HSCs), play important roles in HCV-induced infl ammation. In the current study, we found evidence of cross-talk between HCV-infected hepatocytes and HSCs, revealed by the production of cytokines and chemokines. Upon co-culture of HSCs with HCV-infected hepatocytes in vitro, HSCs stimulated HCV-infected hepatocytes to produce pro-infl ammatory cytokines and chemokines, including interleukin (IL)-6, IL-8, macrophage infl ammatory protein (MIP)-1α and MIP-1β. This cross-talk is likely to be a key feature of infl ammatory diseases caused by HCV infection.

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Extracellular Hepatitis C Virus Core Protein Activates STAT3 in Human Monocytes/Macrophages/Dendritic Cells via an IL-6 Autocrine Pathway

Cited by 87 publications

References 44 publications

The Role of Myeloid-Derived Suppressor Cells in Viral Infection

The Role of Myeloid-Derived Suppressor Cells in Viral Infection

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors

Hepatitis C Virus (HCV)-Induced Inflammation: The Role of Cross-Talk Between HCV-Infected Hepatocytes and Stellate Cells

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