2010
DOI: 10.1016/j.brainres.2010.08.086
|View full text |Cite
|
Sign up to set email alerts
|

Extracellular hydrogen peroxide contributes to oxidative glutamate toxicity

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
34
0

Year Published

2012
2012
2017
2017

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 37 publications
(34 citation statements)
references
References 36 publications
0
34
0
Order By: Relevance
“…Accumulation of oxidants or overconsumption of antioxidants will damage cellular metabolism and even result in cell death [27]. In this study, we found that when in conditions of oxidative stress AEA raised intracellular SOD and GSH, reduced GSSG, and increased the GSH/GSSG ratio, and these effects were reversed by CB1 antagonist AM251, indicating that AEA could restore the balance of intracellular antioxidative and oxidative substances via CB1 receptor.…”
Section: Discussionmentioning
confidence: 55%
“…Accumulation of oxidants or overconsumption of antioxidants will damage cellular metabolism and even result in cell death [27]. In this study, we found that when in conditions of oxidative stress AEA raised intracellular SOD and GSH, reduced GSSG, and increased the GSH/GSSG ratio, and these effects were reversed by CB1 antagonist AM251, indicating that AEA could restore the balance of intracellular antioxidative and oxidative substances via CB1 receptor.…”
Section: Discussionmentioning
confidence: 55%
“…NOX2 deletion or DPI mitigates NOX activity, ROS production, and apoptotic death triggered by staurosporine in these cells, which suggests an important role of NOX2 in apoptotic death of neurons [42, 43]. Knockdown of NOX2 and NOX4 expression in cultured HT22 neuronal cells reduces glutamate-induced hydrogen peroxide accumulation and cell death, indicating NOX family contributes to oxidative glutamate toxicity [44]. NOX4 is upregulated in human and mouse brain after ischemia; post -stroke inhibition of NOX4 induction in mice prevents oxidative stress and neurodegeneration [45].…”
Section: Nox Is An Important Source Of Cns Oxidative Stressmentioning
confidence: 99%
“…There are studies indicating that NOX4 may produce H 2 O 2 directly instead of superoxide (16,77). However, a number of studies (26,31,59,68) indicate that NOX4 first produces O 2…”
Section: We Hypothesized That Ang II Stimulates Omentioning
confidence: 99%