Extracellular matrix components in intestinal development

Simon‐Assmann, Patricia; Kédinger, Michèle; Arcangelis, Adèle De; Rousseau, V.; Simo, Pauline

doi:10.1007/bf01921739

Cited by 162 publications

(124 citation statements)

References 140 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…As a similar thing, it is known that the intestine has no anchoring fibrils and little laminin 5. Therefore, it is considered that unknown proteins may bind the mucoepithelium and the lamina propria [30].…”

Section: Discussionmentioning

confidence: 99%

Unilateral Basement Membrane Zone Alteration of the Regenerated Laminar Region in Equine Chronic Laminitis

et al. 2005

View full text Add to dashboard Cite

ABSTRACT. Between the laminar epidermis and the laminar dermis of laminar region (LR) in equine foot, it can be observed the basement membrane zone (BMZ), which is composed of a basement membrane and its accompaniments like the hemidesmosome and anchoring fibril. Alteration in the BMZ in equine laminitis is possibly related with not only development but also recovery outcome and recurrence of this disease. However, there is little known about the structure of the BMZ during the recovery phase of this disease. To assess the condition of the BMZ of LR affected by chronic laminitis, the tissue was examined in three cases at two weeks, four weeks and three months after the onset of laminitis, using pathological, immunohistochemical and electron microscopic techniques. Histologically in all laminitis cases, there was a regenerated laminar epidermis with proliferating keratinocytes between the Stratum medium and the dermis, but it included the undeveloped secondary epidermal laminae (ud-SELs) structure in one side of the primary epidermal laminae, especially in the part of the deep area of LR. Immunohistochemical results were positive for the anti-type IV collagen, anti-type VII collagen and anti-laminin 5 antibodies in the most BMZs. However, partial BMZs adjacent to the ud-SELs were negative for the anti-type VII collagen and anti-laminin 5 antibodies. Ultrastructurally, in the BMZ of the ud-SEL, the lamina densa and the lamina lucida were present. In contrast, the anchoring fibrils and the hemidesmosomes were either absent, or present at lower than normal levels. In conclusion, the present study indicated that the part of regenerated LR in chronic laminitis was not able to fully restore to construct the BMZ for a long time, especially in the unilateral side of laminar epidermis. It might be related with recurrence of this disease. KEY WORDS: basement membrane zone, chronic laminitis, collagen, equine, laminin 5.J. Vet. Med. Sci. 67 (7): [685][686][687][688][689][690][691] 2005 The integumental tissues of the foot are important in supporting the horse's entire body weight during static and dynamic loading conditions. If severe intractable hoof disease occurs, the horse may lose not only the ability to run, but also to stand. Laminitis is one such intractable hoof condition and has a recurrent nature. Many horses have suffered from this disease over extended periods, resulting in significant treatment costs, and therefore the equine industry has a great deal of interest in clarifying the pathogenesis and developing treatment methods [5,9,12].Anatomically, the laminar region in foot displays a complex 3-dimensional structure consisting of the primary epidermal lamina (PEL) and the secondary epidermal lamina (SEL) which interdigitate with their dermal counterparts [24]. These dermal and epidermal components are separated by the basement membrane zone (BMZ), which is composed of a basement membrane and its accompaniments like the hemidesmosome and anchoring fibril [23]. The hemidesmosome, anchoring fibril and other c...

show abstract

Section: Discussionmentioning

confidence: 99%

Unilateral Basement Membrane Zone Alteration of the Regenerated Laminar Region in Equine Chronic Laminitis

et al. 2005

View full text Add to dashboard Cite

show abstract

“…BM molecules are produced in cooperation between epithelial and mesenchymal cells. 2 Collagen type IV is a helical, trimeric protein. The most widely expressed type IV collagen trimer is composed of 2 ␣1(IV) chains and one ␣2(IV) chain.…”

mentioning

confidence: 99%

Laminin-5 in the progression of carcinomas

Lohi¹

2001

Int. J. Cancer

112

View full text Add to dashboard Cite

The basement membrane (BM) separates epithelial elements from the surrounding stroma. BM is dynamic in regulation of epithelial cells differentiation as well as their organization into 3-dimensional tissues. In these functions, among the molecules of the BM, laminins are especially dynamic. Laminins are distributed in a spatially and temporally regulated manner in various epithelial tissues. Various changes in the laminin distribution accompany the malignant transformation of epithelia. The role of the BM and laminins in the progression of carcinomas is not well understood. The BM has been suggested to act as a mechanical barrier against carcinoma cell invasion. BM laminins may play an active role in regulating the migration and proliferation of the carcinoma cells. Laminin isoform laminin-5 expression is typical for some invasive carcinomas and it may act as a ligand for invading carcinoma cells. Neoexpression of laminin-5 has also been associated to proliferative activity of the carcinoma cells. Integrins ␣ 3 ␤ 1 and ␣ 6 ␤ 4 are probable cell surface receptors acting with laminin-5 in the regulation of carcoma cell invasion and proliferation. © 2001 Wiley-Liss, Inc. Key words: laminin-5; carcinomas; invasion; integrin; basement membranesBasement membrane (BM) is a densified sheet of proteins of the extracellular matrix. The BM separates connective tissue from epithelium. In addition, endothelium, various types of muscle cell, lipocytes and Schwann cells are surrounded by BM. 1 Structural components of the BM are at least laminins, type IV collagens, nidogens, proteoglycans such as perlecan, fibulins as well as type VII collagen in the BMs containing lamina fibroreticularis layer. Additionally, fibronectin and tenascin are often located to the BM region, but they are not the structural components of the BMs. BM molecules are produced in cooperation between epithelial and mesenchymal cells. 2 Collagen type IV is a helical, trimeric protein. The most widely expressed type IV collagen trimer is composed of 2 ␣1(IV) chains and one ␣2(IV) chain. 3 The ␣3(IV)-␣6(IV) chains have a more restricted tissue distribution, present for example in the kidney. 4 -6 Nidogen-1 is a 150 kD glycoprotein consisting of three globular domains. 7 It binds collagen IV and laminin networks together. 8 Nidogen-1 binds also perlecan, fibulin-1 and fibulin-2. 9 Type VII collagen forms the anchoring fibrils and connects the BM lamina densa to the underlying connective tissue at least in BMs of stratified epithelium. 10,11 Type VII collagen binds, laminin-5 and type IV collagen. 12 The functions of BM in offering mechanical support are well known. 1 In addition to mechanical functions, the BM influences for cell proliferation, differentiation, adhesion, migration and gene expression. 13,14 BM acts as a factor in maintaining polarity and organization of epithelial cells 1,13,15,16 and it is an active regulator in epithelial-mesenchymal interactions during epithelial cell development. 17 BM molecules can regulate the activity of growth facto...

show abstract

“…Given that the BM exists as an interface between tissues of endodermal and mesodermal origin it is not surprising that the intestinal BM itself has a dual origin, from both intestinal epithelial and mesenchymal cells [13,25,26]. Mesenchymal intestinal subepithelial myofibroblasts produce the majority of the BM's type IV collagen and entactin [13,27]. Laminin is produced commensurately by epithelial and mesenchymal cells and perlecan primarily from the epithelial compartment [13,27].…”

Section: Synthesis Of the Basement Membranementioning

confidence: 99%

“…Mesenchymal intestinal subepithelial myofibroblasts produce the majority of the BM's type IV collagen and entactin [13,27]. Laminin is produced commensurately by epithelial and mesenchymal cells and perlecan primarily from the epithelial compartment [13,27].…”

Section: Synthesis Of the Basement Membranementioning

confidence: 99%

See 1 more Smart Citation

The Extracellular Matrix in Digestive Cancer

Worthley

Giraud

Wang

2010

Cancer Microenvironment

View full text Add to dashboard Cite

The extracellular components of the cancer microenvironment play a critical role in tumor initiation, progression and invasion. In this review we examine the normal formation and function of the basement membrane and extracellular matrix. We characterize the interactions between the matrix and the epithelium and explore the causes and consequences of the extracellular remodeling that accompanies carcinogenesis. Finally, we address the therapeutic possibilities of incorporating matrix as well as epithelial strategies in the management of digestive cancer.

show abstract

Extracellular matrix components in intestinal development

Cited by 162 publications

References 140 publications

Unilateral Basement Membrane Zone Alteration of the Regenerated Laminar Region in Equine Chronic Laminitis

Unilateral Basement Membrane Zone Alteration of the Regenerated Laminar Region in Equine Chronic Laminitis

Laminin-5 in the progression of carcinomas

The Extracellular Matrix in Digestive Cancer

Contact Info

Product

Resources

About