2023
DOI: 10.3389/fcvm.2023.1169331
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Extracellular matrix cues regulate the differentiation of pluripotent stem cell-derived endothelial cells

Abstract: The generation of endothelial cells (ECs) from human pluripotent stem cells (PSCs) has been a promising approach for treating cardiovascular diseases for several years. Human PSCs, particularly induced pluripotent stem cells (iPSCs), are an attractive source of ECs for cell therapy. Although there is a diversity of methods for endothelial cell differentiation using biochemical factors, such as small molecules and cytokines, the efficiency of EC production varies depending on the type and dose of biochemical fa… Show more

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Cited by 3 publications
(3 citation statements)
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“…Endogenous stress, which includes factors such as the topology and matrix stiffness of the ECM, has been widely reported to regulate stem cell differentiation into various phenotypes. Matrix stiffness, in particular, has been extensively studied in the context of stem cell differentiation [ 217 , 218 , 219 ]. Stem cells perceive the stiffness of their microenvironment, and this mechanical cue can impact differentiation.…”
Section: Bone Tissue Engineering: Combining Stem Cells Scaffolds the ...mentioning
confidence: 99%
See 1 more Smart Citation
“…Endogenous stress, which includes factors such as the topology and matrix stiffness of the ECM, has been widely reported to regulate stem cell differentiation into various phenotypes. Matrix stiffness, in particular, has been extensively studied in the context of stem cell differentiation [ 217 , 218 , 219 ]. Stem cells perceive the stiffness of their microenvironment, and this mechanical cue can impact differentiation.…”
Section: Bone Tissue Engineering: Combining Stem Cells Scaffolds the ...mentioning
confidence: 99%
“…Stem cells perceive the stiffness of their microenvironment, and this mechanical cue can impact differentiation. For example, a stiff substrate provides a mechanical load that promotes actomyosin assembly and cell spreading, which can influence cell behaviour, including differentiation [ 218 ]. The topology of the ECM, or its 3D structure, also regulates the osteogenic and osteoclastic effects in bone tissue.…”
Section: Bone Tissue Engineering: Combining Stem Cells Scaffolds the ...mentioning
confidence: 99%
“…In addition, the mechanical environment established by cd-ECMs is a non-negligible element that affects cell behavior. Cells can sense physical properties of ECMs, including stiffness, porosity, topography, ultrastructure, and other biomechanical characteristics, and modify their shape, geometry, phenotype, function, and lineage commitment in response to the surrounding ECMs [ 129 , 133 ].…”
Section: Functional Properties and Mechanisms Of Cd-ecmsmentioning
confidence: 99%