2024
DOI: 10.3389/fimmu.2024.1401751
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Extracellular matrix substrates differentially influence enteric glial cell homeostasis and immune reactivity

Linda Schneider,
Reiner Schneider,
Ebrahim Hamza
et al.

Abstract: IntroductionEnteric glial cells are important players in the control of motility, intestinal barrier integrity and inflammation. During inflammation, they switch into a reactive phenotype enabling them to release inflammatory mediators, thereby shaping the inflammatory environment. While a plethora of well-established in vivo models exist, cell culture models necessary to decipher the mechanistic pathways of enteric glial reactivity are less well standardized. In particular, the composition of extracellular ma… Show more

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